Patents by Inventor Gaetano R. Barile

Gaetano R. Barile has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CLEARANCE OF BIOACTIVE LIPIDS FROM MEMBRANE STRUCTURES BY CYCLODEXTRINS
    Publication number: 20160151410
    Abstract: The present invention provides a method of treating a subject suffering from wet acute macular degeneration which comprises administering to the subject an amount of a modified alpha cyclodextrin effective to treat the subject, wherein the modified alpha cyclodextrin binds to bioactive lipids which accumulate in the subject's eye and are characterized by the presence of a single chain of fatty acids.
    Type: Application
    Filed: June 30, 2014
    Publication date: June 2, 2016
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Wanchao MA, Gaetano R. BARILE, David Choohyun PAIK
  • RAGE AS A C1Q RECEPTOR, METHODS AND APPLICATIONS
    Publication number: 20160139120
    Abstract: A method of identifying a compound capable of reducing or increasing the amount of the receptor for RAGE-C1q Binding comprising a) providing an amount of the compound to be tested; b) contacting the amount of the compound with C1q and RAGE; c) measuring the amount of RAGE-C1q binding in step b); d) comparing the amount of RAGE-C1q binding measured in step c) with the amount of RAGE-C1q binding measured under corresponding conditions in the absence of the compound; and e) identifying the compound as capable of reducing or increasing the amount of RAGE-C1q binding. The present invention also provides a method of treating a subject suffering from a RAGE-related disorder comprising administering to the subject a therapeutically effective amount of a compound that is a modulator of the amount of RAGE-C1q binding so as to thereby treat the subject.
    Type: Application
    Filed: February 12, 2014
    Publication date: May 19, 2016
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Gaetano R. BARILE, Ann Marie SCHMIDT, Wanchao MA
  • Polychromatic, diversely-sized particles for angiography
    Publication number: 20090180950
    Abstract: The invention involves polychromatic particles of various sizes for assessing blood flow, blood barrier leakage and blood vessel leakage.
    Type: Application
    Filed: January 6, 2009
    Publication date: July 16, 2009
    Applicants: The Trustees of Columbia University in the City of New York, Board or Regents of the University of Nebraska Varner Hall
    Inventors: Samir R. Tari, Gaetano R. Barile, Uday B. Kompella