Patents by Inventor Gail Besner
Gail Besner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240075079Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.Type: ApplicationFiled: September 28, 2022Publication date: March 7, 2024Inventors: Steven D. Goodman, Lauren O. Bakaletz, Michael Bailey, Gail Besner
-
Publication number: 20230285475Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.Type: ApplicationFiled: August 10, 2022Publication date: September 14, 2023Inventors: Steven D. Goodman, Lauren O. Bakaletz, Gail Besner, Michael Bailey
-
Publication number: 20230141737Abstract: Provided herein are methods for preventing or treating antibiotic induced dysbiosis in a patient by administering to the subject a composition comprising a micro sphere, a bio film-generating probiotic bacterium and a prebiotic, wherein the prebiotic comprises a nutritional supplementation for the probiotic bacterium.Type: ApplicationFiled: October 21, 2019Publication date: May 11, 2023Applicant: RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITALInventors: Gail Besner, Michael Bailey, Steven David Goodman
-
Patent number: 11497780Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.Type: GrantFiled: March 16, 2020Date of Patent: November 15, 2022Assignees: Research Institute at Nationwide Children's Hospital, Ohio State Innovation FoundationInventors: Steven D. Goodman, Lauren O. Bakaletz, Michael Bailey, Gail Besner
-
Patent number: 11452748Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.Type: GrantFiled: June 21, 2019Date of Patent: September 27, 2022Assignees: Research Institute at Nation Children's Hospital, Ohio State Innovation FoundationInventors: Steven D. Goodman, Lauren O. Bakaletz, Gail Besner, Michael Bailey
-
Publication number: 20220162700Abstract: The present invention provides novel methods and kits for determining whether a subject is suffering from endometriosis or an associated disorder. It also provides methods and kits for determining whether a subject suffering from endometriosis or an associated disorder is more or less likely to be responsive to a therapy to treat endometriosis or an associated disorder.Type: ApplicationFiled: July 2, 2021Publication date: May 26, 2022Applicant: RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITALInventors: Li Chen, Yu Zhou, David Brigstock, Gail Besner
-
Publication number: 20220136060Abstract: The present invention provides novel methods and kits for determining whether a subject is suffering from cisplatin-containing resistant ovarian and methods for treating and reversing resistance.Type: ApplicationFiled: July 2, 2021Publication date: May 5, 2022Applicant: RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITALInventors: Li Chen, Yu Zhou, David Brigstock, Gail Besner
-
Publication number: 20220010384Abstract: This disclosure provides methods for determining whether a subject is suffering from a liver cancer, such as hepatic carcinoma, comprising determining the expression level of miRNA-33b and/or miRNA46-a, in a sample of exosomes enriched from a body fluid of the subject, wherein low expression of the miRNA-33b and/or miRNA-46a as compared to a control is indicative of the subject suffering from a liver cancer, e.g., hepatic carcinoma. The subject may also be suffering from a fibrotic disease, liver fibrosis, and/or is or was infected with hepatitis B.Type: ApplicationFiled: July 16, 2021Publication date: January 13, 2022Applicant: RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITALInventors: Li Chen, Yu Zhou, David Brigstock, Gail Besner
-
Publication number: 20220011312Abstract: The present disclosure provides a novel method for monitoring the conversion of oral precancerous lesions to oral cancers, including monitoring changes in oral exosome concentrations in a subject, thereby determining the state of the disease and the risk of carcinogenesis. The disclosure also relates to a detection kit for use in the above method.Type: ApplicationFiled: July 19, 2021Publication date: January 13, 2022Applicant: RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITALInventors: Li Chen, Yu Zhou, David Brigstock, Gail Besner
-
Publication number: 20210290701Abstract: Provided herein are prenatal methods comprising administering an effective amount of a biocompatible microsphere comprising a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic.Type: ApplicationFiled: August 2, 2019Publication date: September 23, 2021Applicant: RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITALInventors: Gail Besner, Steven D. Goodman, Michael Bailey
-
Publication number: 20210100854Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.Type: ApplicationFiled: March 16, 2020Publication date: April 8, 2021Inventors: Steven D. Goodman, Lauren O. Bakaletz, Michael Bailey, Gail Besner
-
Publication number: 20200155620Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.Type: ApplicationFiled: June 21, 2019Publication date: May 21, 2020Applicants: Research Institute at Nationwide Children's Hospital, Ohio State Innovation FoundationInventors: Steven D. Goodman, Lauren O. Bakaletz, Gail Besner, Michael Bailey
-
Patent number: 10624934Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.Type: GrantFiled: July 13, 2017Date of Patent: April 21, 2020Assignees: Research Institute at Nationwide Children's Hospital, Ohio State Innovation FoundationInventors: Steven D. Goodman, Lauren O. Bakaletz, Michael Bailey, Gail Besner
-
Patent number: 10369176Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.Type: GrantFiled: September 6, 2016Date of Patent: August 6, 2019Assignees: Research Institute at Nationwide Children's Hospital, Ohio State Innovation FoundationInventors: Steven D. Goodman, Lauren O. Bakaletz, Gail Besner, Michael Bailey
-
Publication number: 20180000878Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.Type: ApplicationFiled: July 13, 2017Publication date: January 4, 2018Applicant: Research Institute at Nationwide Children's HospitalInventors: Steven D. Goodman, Lauren O. Bakaletz, Michael Bailey, Gail Besner
-
Publication number: 20170209504Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.Type: ApplicationFiled: September 6, 2016Publication date: July 27, 2017Applicants: Research Institute at Nationwide Children's Hospital, Ohio State Innovation FoundationInventors: Steven D. Goodman, Lauren O. Bakaletz, Gail Besner, Michael Bailey
-
Publication number: 20060019898Abstract: The present invention provides methods of treating pathologic conditions associated with intestinal ischemia. In the methods, patients at risk for or suffering from intestinal ischemia are treated with a heparin-binding epidermal growth factor product.Type: ApplicationFiled: August 23, 2005Publication date: January 26, 2006Applicant: Children's Hospital, Inc., A Not-for-Profit CorporationInventors: Gail Besner, Srikumar Pillai