Patents by Inventor Gakuji Hashimoto
Gakuji Hashimoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11971355Abstract: A fluorescence observation apparatus according to an embodiment of the present technology includes a stage, an excitation section, and a spectroscopic imaging section. The stage is capable of supporting a fluorescently stained pathological specimen. The excitation section irradiates the pathological specimen on the stage with a plurality of line illuminations of different wavelengths, the plurality of line illuminations being a plurality of line illuminations situated on different axes and parallel to a certain-axis direction. The spectroscopic imaging section includes at least one imaging device capable of separately receiving pieces of fluorescence respectively excited with the plurality of line illuminations.Type: GrantFiled: April 25, 2023Date of Patent: April 30, 2024Assignee: Sony Group CorporationInventors: Hirokazu Tatsuta, Gakuji Hashimoto, Tetsuro Kuwayama
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Patent number: 11927524Abstract: To provide a technology of optimizing a suction condition of a microparticle. The present technology provides an optimizing method of a suction condition of a microparticle including: a particle number counting step of detecting a time point when a microparticle passes through a predetermined position on a main flow path through which liquid containing the microparticle flows, sucking the microparticle from the main flow path to a microparticle suction flow path by the microparticle suction flow path with a predetermined suction force, and counting the number of microparticles sucked into the microparticle suction flow path; and a step of determining an elapsed time from passage through the predetermined position with which the suction by the microparticle suction flow path should be performed on the basis of a time from the time point when the microparticle passes through the predetermined position on the main flow path until the suction is performed and the number of counted microparticles.Type: GrantFiled: November 7, 2022Date of Patent: March 12, 2024Assignee: Sony Group CorporationInventors: Gakuji Hashimoto, Tatsumi Ito, Kazuya Takahashi, Junji Kajihara
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Publication number: 20230375459Abstract: Provided is a technology for increasing accuracy of a technology which optically detects characteristics of each of particles contained in fluid and analyzes or isolates the detected particles. Provided is a particle detection device including a light applying unit that applies excitation light to a particle contained in fluid, a light detection unit that detects light emitted by application of the excitation light, and an excitation light detection unit that has an imaging element that detects the excitation light applied to the particle. The light applying unit of the particle detection device according to the present technology may be configured to apply multiple rays of excitation light having different wavelengths from different positions in a flow direction of the fluid. In this case, the excitation light detection unit can detect position information associated with the multiple rays of excitation light.Type: ApplicationFiled: October 15, 2021Publication date: November 23, 2023Applicant: Sony Group CorporationInventors: Gakuji Hashimoto, Mitsunori Ueda, Tsutomu Maruyama, Isao Hidaka
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Publication number: 20230266245Abstract: A fluorescence observation apparatus according to an embodiment of the present technology includes a stage, an excitation section, and a spectroscopic imaging section. The stage is capable of supporting a fluorescently stained pathological specimen. The excitation section irradiates the pathological specimen on the stage with a plurality of line illuminations of different wavelengths, the plurality of line illuminations being a plurality of line illuminations situated on different axes and parallel to a certain-axis direction. The spectroscopic imaging section includes at least one imaging device capable of separately receiving pieces of fluorescence respectively excited with the plurality of line illuminations.Type: ApplicationFiled: April 25, 2023Publication date: August 24, 2023Applicant: Sony Group CorporationInventors: Hirokazu Tatsuta, Gakuji Hashimoto, Tetsuro Kuwayama
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Patent number: 11662316Abstract: A fluorescence observation apparatus according to an embodiment of the present technology includes a stage, an excitation section, and a spectroscopic imaging section. The stage is capable of supporting a fluorescently stained pathological specimen. The excitation section irradiates the pathological specimen on the stage with a plurality of line illuminations of different wavelengths, the plurality of line illuminations being a plurality of line illuminations situated on different axes and parallel to a certain-axis direction. The spectroscopic imaging section includes at least one imaging device capable of separately receiving pieces of fluorescence respectively excited with the plurality of line illuminations.Type: GrantFiled: May 30, 2019Date of Patent: May 30, 2023Assignee: Sony CorporationInventors: Hirokazu Tatsuta, Gakuji Hashimoto, Tetsuro Kuwayama
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Publication number: 20230053597Abstract: To provide a technology of optimizing a suction condition of a microparticle. The present technology provides an optimizing method of a suction condition of a microparticle including: a particle number counting step of detecting a time point when a microparticle passes through a predetermined position on a main flow path through which liquid containing the microparticle flows, sucking the microparticle from the main flow path to a microparticle suction flow path by the microparticle suction flow path with a predetermined suction force, and counting the number of microparticles sucked into the microparticle suction flow path; and a step of determining an elapsed time from passage through the predetermined position with which the suction by the microparticle suction flow path should be performed on the basis of a time from the time point when the microparticle passes through the predetermined position on the main flow path until the suction is performed and the number of counted microparticles.Type: ApplicationFiled: November 7, 2022Publication date: February 23, 2023Applicant: Sony Group CorporationInventors: Gakuji Hashimoto, Tatsumi Ito, Kazuya Takahashi, Junji Kajihara
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Publication number: 20220413275Abstract: A microscope device includes an opening (31) that includes a first slit and a second slit through which a plurality of pieces of light from an observation target resulting from a plurality of pieces of irradiation light emitted to the observation target and having different wavelengths pass, a dispersion element that wavelength-disperses the plurality of pieces of light passing through the opening (31), and an imaging element (32) that receives the plurality of pieces of light wavelength-dispersed by the dispersion element. The imaging element (32) performs light reception so that, as for the plurality of pieces of light wavelength-dispersed, zeroth-order light of light passing through the second slit and first-order light of light passing through the first slit do not overlap with each other.Type: ApplicationFiled: November 20, 2020Publication date: December 29, 2022Inventors: TETSURO KUWAYAMA, HIROKAZU TATSUTA, GAKUJI HASHIMOTO
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Patent number: 11525767Abstract: To provide a technology of optimizing a suction condition of a microparticle. The present technology provides an optimizing method of a suction condition of a microparticle including: a particle number counting step of detecting a time point when a microparticle passes through a predetermined position on a main flow path through which liquid containing the microparticle flows, sucking the microparticle from the main flow path to a microparticle suction flow path by the microparticle suction flow path with a predetermined suction force, and counting the number of microparticles sucked into the microparticle suction flow path; and a step of determining an elapsed time from passage through the predetermined position with which the suction by the microparticle suction flow path should be performed on the basis of a time from the time point when the microparticle passes through the predetermined position on the main flow path until the suction is performed and the number of counted microparticles.Type: GrantFiled: February 14, 2018Date of Patent: December 13, 2022Assignee: Sony CorporationInventors: Gakuji Hashimoto, Tatsumi Ito, Kazuya Takahashi, Junji Kajihara
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Publication number: 20210372917Abstract: The present technology is to provide a technique for further optimizing microparticle suction conditions, using a microparticle sorting microchip. The present technology provides a method for optimizing microparticle suction conditions, using a microparticle sorting microchip including: a main flow channel in which a sheath solution and a microparticle-containing sample solution flow; and a pressure chamber that sucks microparticles. The method includes: the step of acquiring data of a velocity V of each microparticle, by introducing the sheath solution and the microparticle-containing sample solution into the main flow channel, and detecting the point of time at which the microparticle passes through a predetermined position in the main flow channel; and the step of controlling the pressure for sucking the microparticles, on the basis of the data of the velocity V of each microparticle.Type: ApplicationFiled: January 28, 2019Publication date: December 2, 2021Applicant: Sony CorporationInventor: Gakuji Hashimoto
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Patent number: 11169074Abstract: In the present technology, the timing at which suction is performed is optimized in order to enhance the microparticle separation performance in a technology for separating target microparticles in a microchip. For this purpose, the present technology provides a method of optimizing a microparticle suction condition, and the like, using a microchip having a main flow channel through which a liquid containing a microparticle flows, a microparticle suction flow channel arranged coaxially with the main flow channel, and a branch flow channel branching from the main flow channel. The method includes: a branch point specifying process of specifying a branch point at which the branch flow channel branches from the main flow channel; and a time assignment process of assigning a time T1 to be applied to suction of the microparticle.Type: GrantFiled: February 20, 2018Date of Patent: November 9, 2021Assignee: SONY CORPORATIONInventors: Gakuji Hashimoto, Tatsumi Ito, Kazuya Takahashi, Junji Kajihara
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Publication number: 20210331172Abstract: Provided is a technology for preparing a mixture including multiple types of microparticles in accordance with a predetermined ratio. The present technology provides a microparticle sorting device (100) including a control unit (103) comprising a determination unit that determines whether microparticles are sorted, on the basis of light generated by irradiating, with light, the microparticles flowing through a flow channel (155), in which the determination unit performs a primary sorting determination to determine, on the basis of characteristics of the light generated, whether the microparticles belong to any one of two or more different microparticle populations, and then performs a secondary sorting determination to determine whether the microparticles determined to belong to any one of the microparticle populations in the primary sorting determination are sorted, on the basis of the particle constituent ratio specified for the two or more different microparticle populations.Type: ApplicationFiled: September 10, 2019Publication date: October 28, 2021Applicant: Sony CorporationInventors: Tatsumi Ito, Gakuji Hashimoto, Kazuya Takahashi, Hirotaka Yoshida, Yasunobu Kato
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Publication number: 20210199585Abstract: A fluorescence observation apparatus according to an embodiment of the present technology includes a stage, an excitation section, and a spectroscopic imaging section. The stage is capable of supporting a fluorescently stained pathological specimen. The excitation section irradiates the pathological specimen on the stage with a plurality of line illuminations of different wavelengths, the plurality of line illuminations being a plurality of line illuminations situated on different axes and parallel to a certain-axis direction. The spectroscopic imaging section includes at least one imaging device capable of separately receiving pieces of fluorescence respectively excited with the plurality of line illuminations.Type: ApplicationFiled: May 30, 2019Publication date: July 1, 2021Applicant: Sony CorporationInventors: Hirokazu Tatsuta, Gakuji Hashimoto, Tetsuro Kuwayama
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Publication number: 20200124517Abstract: In the present technology, the timing at which suction is performed is optimized in order to enhance the microparticle separation performance in a technology for separating target microparticles in a microchip. For this purpose, the present technology provides a method of optimizing a microparticle suction condition, and the like, using a microchip having a main flow channel through which a liquid containing a microparticle flows, a microparticle suction flow channel arranged coaxially with the main flow channel, and a branch flow channel branching from the main flow channel.Type: ApplicationFiled: February 20, 2018Publication date: April 23, 2020Inventors: GAKUJI HASHIMOTO, TATSUMI ITO, KAZUYA TAKAHASHI, JUNJI KAJIHARA
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Publication number: 20200072732Abstract: To provide a technology of optimizing a suction condition of a microparticle. The present technology provides an optimizing method of a suction condition of a microparticle including: a particle number counting step of detecting a time point when a microparticle passes through a predetermined position on a main flow path through which liquid containing the microparticle flows, sucking the microparticle from the main flow path to a microparticle suction flow path by the microparticle suction flow path with a predetermined suction force, and counting the number of microparticles sucked into the microparticle suction flow path; and a step of determining an elapsed time from passage through the predetermined position with which the suction by the microparticle suction flow path should be performed on the basis of a time from the time point when the microparticle passes through the predetermined position on the main flow path until the suction is performed and the number of counted microparticles.Type: ApplicationFiled: February 14, 2018Publication date: March 5, 2020Applicant: Sony CorporationInventors: Gakuji Hashimoto, Tatsumi Ito, Kazuya Takahashi, Junji Kajihara
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Publication number: 20200032184Abstract: The present technology provides a technology capable of performing stable liquid feeding. For this, the present technology provides a cell sample liquid feeding bag or the like including at least: an outflow port from which cell sample liquid flows out; a bottom portion including a reservoir unit capable of reserving cells and at least partly including a slope; and a first inner tube extending from the outflow port toward the reservoir unit to a position not contacting the reservoir unit, and the cell sample liquid is fed from a reservoir unit side toward an outflow port side of the first inner tube.Type: ApplicationFiled: February 28, 2018Publication date: January 30, 2020Inventors: SHINJI TASHIRO, GAKUJI HASHIMOTO, KAZUYA TAKAHASHI, YOICHI KATSUMOTO, NAOHISA SAKAMOTO
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Patent number: 10184877Abstract: A sample feeding apparatus includes a first cylinder, a second cylinder, and a sealing section. The first cylinder is configured to be mounted with a sample tube. The second cylinder is configured to move the first cylinder between a first position and a second position, the first position being for mounting of the sample tube, the second position being for feeding of a sample in the sample tube. The sealing section is configured to cover the sample tube, the sample tube being mounted to the first cylinder being at the second position, the first cylinder applying pressure to an inner space of the sealing section at the second position.Type: GrantFiled: February 2, 2017Date of Patent: January 22, 2019Assignee: Sony CorporationInventors: Gakuji Hashimoto, Takayuki Kato
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Patent number: 9766174Abstract: Disclosed herein is an optical measuring device including: a light applying section configured to apply exciting light to a sample flowing in a channel; and a scattered light detecting section configured to detect scattered light generated from the sample irradiated with the exciting light on the downstream side of the sample in the traveling direction of the exciting light; the scattered light detecting section including a scattered light separating mask for separating the scattered light into a low numerical aperture component having a numerical aperture not greater than a specific value and a high numerical aperture component having a numerical aperture greater than the specific value; a first detector for detecting the low numerical aperture component; and a second detector for detecting the high numerical aperture component.Type: GrantFiled: June 11, 2014Date of Patent: September 19, 2017Assignee: Sony CorporationInventors: Shunpei Suzuki, Shingo Imanishi, Gakuji Hashimoto, Suguru Dowaki
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Patent number: D869308Type: GrantFiled: August 4, 2017Date of Patent: December 10, 2019Assignee: SONY CORPORATIONInventors: Yuji Akiyama, Shoji Akiyama, Gakuji Hashimoto, Hiroto Kasai, Masaya Kakuta, Takeshi Yamasaki, Tatsumi Ito, Masataka Shinoda
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Patent number: D907242Type: GrantFiled: December 20, 2012Date of Patent: January 5, 2021Assignee: SONY CORPORATIONInventors: Masataka Shinoda, Shoji Akiyama, Masaya Kakuta, Takeshi Yamasaki, Tatsumi Ito, Yuji Akiyama, Gakuji Hashimoto, Hiroto Kasai
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Patent number: D960740Type: GrantFiled: November 27, 2019Date of Patent: August 16, 2022Assignee: SONY CORPORATIONInventors: Yuji Akiyama, Shoji Akiyama, Gakuji Hashimoto, Hiroto Kasai, Masaya Kakuta, Takeshi Yamasaki, Tatsumi Ito, Masataka Shinoda