Abstract: Antibodies or antigen binding fragments thereof that bind HVEM, inhibit HVEM-BTLA interaction and allow binding to LIGHT are provided. Methods of treating disease with these antibodies or antigen binding fragments thereof, nucleic acid molecules encoding these antibodies or antigen binding fragments thereof and kits comprising these antibodies or antigen binding fragments thereof are also provided.

Abstract: A water intake and pretreatment system (10) comprising an inlet for delivering water from a natural source to a reservoir (12); said inlet to reservoir having a net screen (16) to prevent entry of organisms above a predetermined size and including a one-way gate (30) to allow organisms to exit the reservoir; said reservoir further comprising a granular filter media for water and algae filtration; and a drainage layer for removal of filtered water from the granular filter media to a drainage outlet. A local backwashing apparatus (40) is included for localized backwashing of the granular filter media.

Abstract: A water intake and pretreatment system (10) comprising an inlet for delivering water from a natural source to a reservoir (12); said inlet to reservoir having a net screen (16) to prevent entry of organisms above a predetermined size and including a one-way gate (30) to allow organisms to exit the reservoir; said reservoir further comprising a granular filter media for water and algae filtration; and a drainage layer for removal of filtered water from the granular filter media to a drainage outlet. A local backwashing apparatus 40) is included for localized backwashing of the granular filter media.

Abstract: A water intake and pretreatment system (10) comprising an inlet for delivering water from a natural source to a reservoir (12); said inlet to reservoir having a net screen (16) to prevent entry of organisms above a predetermined size and including a one-way gate (30) to allow organisms to exit the reservoir; said reservoir further comprising a granular filter media for water and algae filtration; and a drainage layer for removal of filtered water from the granular filter media to a drainage outlet. A local backwashing apparatus (40) is included for localized backwashing of the granular filter media.

Abstract: Locally backwashing portions of filter media allows a simple and effective design of intake and pretreatment units, as well as their integration. An enclosure is used to limit portions of filter media and backwash them locally by suction, utilizing filtered water from adjacent filter media as the back wash water. Wastewater is produced at small amounts that allows efficient sludge treatment. This design enables water pretreatment at the intake unit, simplifying overall plant design and preventing damage to organisms living outside the intake unit.

Abstract: Locally backwashing portions of filter media allows a simple and effective design of intake and pretreatment units, as well as their integration. An enclosure is used to limit portions of filter media and backwash them locally by suction, utilizing filtered water from adjacent filter media as the back wash water. Wastewater is produced at small amounts that allows efficient sludge treatment. This design enables water pretreatment at the intake unit, simplifying overall plant design and preventing damage to organisms living outside the intake unit.

Abstract: Locally backwashing portions of filter media allows a simple and effective design of intake and pretreatment units, as well as their integration. An enclosure is used to limit portions of filter media and backwash them locally by suction, utilizing filtered water from adjacent filter media as the back wash water. Wastewater is produced at small amounts that allows efficient sludge treatment. This design enables water pretreatment at the intake unit, simplifying overall plant design and preventing damage to organisms living outside the intake unit.

Abstract: A local backwashing apparatus 110 for a filtering system comprises an enclosure 119 having an open lower end, positionable above a surface of filter media 92 supported by a drainage layer 96. The enclosure is connected to a mechanical member (300, FIG. 6A) configured to force the enclosure into the filter media and release the force prior to the lower end of the enclosure contacting the drainage layer. The lower end of the enclosure being brought into contact with the drainage layer through a pressure differential between the interior and exterior of the enclosure. A pneumatic system such as an air pump, is in fluid communication with the upper part 127 of the enclosure and is configured to determine an air pressure therein. A pipe system connects the upper part of the enclosure with the pneumatic system and with a discharge structure 132. A control unit is connected to the pneumatic system. Also disclosed is a method of backwashing a filtering system. The backwashing apparatus may be used to pre-treat water.

Abstract: Locally backwashing portions of filter media allows a simple and effective design of intake and pretreatment units, as well as their integration. An enclosure is used to limit portions of filter media and backwash them locally by suction, utilizing filtered water from adjacent filter media as the back wash water. Wastewater is produced at small amounts that allows efficient sludge treatment. This design enables water pretreatment at the intake unit, simplifying overall plant design and preventing damage to organisms living outside the intake unit.

Abstract: A water intake and pretreatment system (10) comprising an inlet for delivering water from a natural source to a reservoir (12); said inlet to reservoir having a net screen (16) to prevent entry of organisms above a predetermined size and including a one-way gate (30) to allow organisms to exit the reservoir; said reservoir further comprising a granular filter media for water and algae filtration; and a drainage layer for removal of filtered water from the granular filter media to a drainage outlet. A local backwashing apparatus (40) is included for localized backwashing of the granular filter media.

Abstract: A desalination system (100) having an intake unit (110) providing seawater to a pre-treatment unit (120) connected to a reverse osmosis (RO) desalination unit (130) and a post treatment unit (150). The desalination system (100) is configured to operate without any external addition of chemicals to simplify logistics and regulation concerns. The units of the system are configured to prevent biofouling, scaling and corrosion by mechanical and biological means including high flow speeds, biological flocculation of colloids, and making the water entering the RO units inhospitable to bacteria and other organisms that cause biofouling, hence preventing their settlement and removing them with the brine. Recovery rate is lowered and energy is recovered to increase the energetic efficiency and minerals that are added to the product water are taken from the brine.

Abstract: A local backwashing apparatus 110 for a filtering system comprises an enclosure 119 having an open lower end, positionable above a surface of filter media 92 supported by a drainage layer 96. The enclosure is connected to a mechanical member (300, FIG. 6A) configured to force the enclosure into the filter media and release the force prior to the lower end of the enclosure contacting the drainage layer. The lower end of the enclosure being brought into contact with the drainage layer through a pressure differential between the interior and exterior of the enclosure. A pneumatic system such as an air pump, is in fluid communication with the upper part 127 of the enclosure and is configured to determine an air pressure therein. A pipe system connects the upper part of the enclosure with the pneumatic system and with a discharge structure 132. A control unit is connected to the pneumatic system. Also disclosed is a method of backwashing a filtering system. The backwashing apparatus may be used to pre-treat water.

Abstract: A backwashing apparatus 110 for a filtering system comprises and enclosure 119 having an open lower end, positionable above a surface of filter media 92 supported by a drainage area 96. A pneumatic system such as an air pump, is in fluid communication with the upper part 127 of the enclosure and is configured to determine an air pressure therein. A pipe system connects the upper part of the enclosure with the pneumatic system and with a discharge structure 132. A control unit is connected to the pneumatic system. The enclosure is provided with a water inlet 120 for selective delivery of water from outside the enclosure to within the enclosure during sinking of the enclosure into filter media. Also disclosed is a method of backwashing a filtering system. The backwashing apparatus may be used to pre-treat water.

Abstract: A desalination system (100) having an intake unit (110) providing seawater to a pre-treatment unit (120) connected to a reverse osmosis (RO) desalination unit (130) and a post treatment unit (150). The desalination system (100) is configured to operate without any external addition of chemicals to simplify logistics and regulation concerns. The units of the system are configured to prevent biofouling, scaling and corrosion by mechanical and biological means including high flow speeds, biological flocculation of colloids, and making the water entering the RO units inhospitable to bacteria and other organisms that cause biofouling, hence preventing their settlement and removing them with the brine. Recovery rate is lowered and energy is recovered to increase the energetic efficiency and minerals that are added to the product water are taken from the brine.

Abstract: A desalination system (100) having an intake unit (110) providing seawater to a pre-treatment unit (120) connected to a reverse osmosis (RO) desalination unit (130) and a post treatment unit (150). The desalination system (100) is configured to operate without any external addition of chemicals to simplify logistics and regulation concerns. The units of the system are configured to prevent biofouling, scaling and corrosion by mechanical and biological means including high flow speeds, biological flocculation of colloids, and making the water entering the RO units inhospitable to bacteria and other organisms that cause biofouling, hence preventing their settlement and removing them with the brine. Recovery rate is lowered and energy is recovered to increase the energetic efficiency and minerals that are added to the product water are taken from the brine.

Abstract: A desalination system (100) having an intake unit (110) providing seawater to a pre-treatment unit (120) connected to a reverse osmosis (RO) desalination unit (130) and a post treatment unit (150). The desalination system (100) is configured to operate without any external addition of chemicals to simplify logistics and regulation concerns. The units of the system are configured to prevent biofouling, scaling and corrosion by mechanical and biological means including high flow speeds, biological flocculation of colloids, and making the water entering the RO units inhospitable to bacteria and other organisms that cause biofouling, hence preventing their settlement and removing them with the brine. Recovery rate is lowered and energy is recovered to increase the energetic efficiency and minerals that are added to the product water are taken from the brine.

Abstract: A desalination system (100) having an intake unit (110) providing seawater to a pre-treatment unit (120) connected to a reverse osmosis (RO) desalination unit (130) and a post treatment unit (150). The desalination system (100) is configured to operate without any external addition of chemicals to simplify logistics and regulation concerns. The units of the system are configured to prevent biofouling, scaling and corrosion by mechanical and biological means including high flow speeds, biological flocculation of colloids, and making the water entering the RO units inhospitable to bacteria and other organisms that cause biofouling, hence preventing their settlement and removing them with the brine. Recovery rate is lowered and energy is recovered to increase the energetic efficiency and minerals that are added to the product water are taken from the brine.

Abstract: Locally backwashing portions of filter media allows a simple and effective design of intake and pretreatment units, as well as their integration. An enclosure is used to limit portions of filter media and backwash them locally by suction, utilizing filtered water from adjacent filter media as the back wash water. Wastewater is produced at small amounts that allows efficient sludge treatment. This design enables water pretreatment at the intake unit, simplifying overall plant design and preventing damage to organisms living outside the intake unit.

Abstract: A desalination system (100) having an intake unit (110) providing seawater to a pre-treatment unit (120) connected to a reverse osmosis (RO) desalination unit (130) and a post treatment unit (150). The desalination system (100) is configured to operate without any external addition of chemicals to simplify logistics and regulation concerns. The units of the system are configured to prevent biofouling, scaling and corrosion by mechanical and biological means including high flow speeds, biological flocculation of colloids, and making the water entering the RO units inhospitable to bacteria and other organisms that cause biofouling, hence preventing their settlement and removing them with the brine. Recovery rate is lowered and energy is recovered to increase the energetic efficiency and minerals that are added to the product water are taken from the brine.