Abstract: A volume of an analyte-enriched fluid can be withdrawn out of a user's subcutaneous compartment using a patch unit that includes a reversible pumping mechanism. The volume can be withdrawn out of the body and into the patch unit through a cannula inserted into the subcutaneous compartment so that an analyte concentration in the volume can be measured using a sensing element within the patch unit. After analyte concentration analysis, at least the volume can be delivered back into the subcutaneous compartment by operating the pumping mechanism in a forward direction. biologically compatible fluid can optionally be pumped into the subcutaneous compartment from a reservoir in the patch unit and then allowed to partially or completely equilibrate with the analyte concentration in the interstitial fluid of the subcutaneous compartment via a permeable or semi-permeable cannula surface before being drawn back into the patch unit for analysis. Related systems, apparatus, methods, and/or articles are also described.

Abstract: Disclosed are systems, devices, and methods, including a system that includes a processor-based device implementing at least a residual insulin (RI) determination unit configured to determine a residual insulin in the patient's body at a particular time instance based on bolus doses previously delivered to the body of the patient, each bolus dose being associated with at least one dose value and a time representative of the time that dose value was delivered to the patient's body, and based on dose dependent RI time records that each includes at least a dose value and an associated duration value representative of dose-dependent duration of therapeutic effectiveness of the associated at least the dose value. The system also includes a pump to controllably dispense the insulin from a reservoir to the body of the patient based on the residual insulin determined by the RI determination unit.

Abstract: A system and a method for delivering fluid to and sensing analyte levels in the body of the patient are disclosed. The system includes a dispensing apparatus configured to infuse fluid into the body of the patient and a sensing apparatus configured to be in communication with the dispensing apparatus and further configured to detect a level of analyte concentration in the body of the patient.

Abstract: A system and a method for delivering fluid to and sensing analyte levels in the body of the patient are disclosed. The system includes a dispensing apparatus configured to infuse fluid into the body of the patient and a sensing apparatus configured to be in communication with the dispensing apparatus and further configured to detect a level of analyte concentration in the body of the patient upon diffusion of the analyte into the fluid to be dispensed by the dispensing apparatus.

Abstract: Embodiments of the present disclosure include methods, systems and devices for selecting a bolus configuration and may include one or more of providing a user interface for selection of one or more user interface elements, where each element corresponds to a bolus configuration of a drug, each element is spatially positioned within a multi-dimensional space corresponding to at least three dimensions and the element's position corresponding to each dimension.

Abstract: A system and a method for determining an assessed carbohydrate to insulin ratio of a patient is described. The system and the method can comprise a memory component adapted for storing an initial set of values comprising at least one of a blood glucose level, a target blood glucose level, an insulin sensitivity, and, an estimated carbohydrate to insulin ratio. The system and the method can also comprise a bolus selection component adapted for selecting a test bolus corresponding to the determined initial set of values and a planned meal. In one implementation, the bolus selection component can receive bolus dose input from a user. In another implementation, the bolus selection component can estimate the bolus dose using a set of available inputs (e.g. the amount of carbohydrates in the planned meal). The system and the method can further comprise a user interface component adapted for receiving a confirmation that the test bolus has been administered to the patient.

Abstract: Methods, systems and devices for assessing residual insulin time of a patient are provided. In one embodiment, the method and the device can be implemented by receiving a confirmation that an insulin dose has been administered to the patient; repetitively receiving a value corresponding to the patient's blood glucose level; identifying at least two consecutively received values based on a predetermined criteria; and, selecting the residual insulin time corresponding to a time period between the confirmation that the insulin dose has been administered and a time corresponding to the identification of the at least two consecutively received values.

Abstract: Systems, devices and methods are presented in the subject disclosure for recommending an insulin dose adapted for use with an insulin delivery device. In some embodiments, the method may include receiving blood glucose (BG) data, determining one or more insulin sensitivity (IS) values associated with the BG data, and determining an insulin dose based on the determined one or more IS values. A system for carrying out such a method is also presented.

Abstract: Devices, systems and methods for determining a recommended bolus dose of therapeutic fluid to be delivered to the body are disclosed. Such a recommended bolus dose may be provided by establishing an initial bolus dose for a user based on one or more first parameters relating to the user and adjusting (e.g., increasing or decreasing) this initial bolus dose amount based on one or more second user parameters by multiplying the initial bolus dose by one or more multiplier values that correlate to at least one of the second parameters and/or by adding or subtracting an absolute value of at least one of the second parameters from the initial bolus dose amount.

Abstract: Devices, systems and methods for adjusting fluid delivery based on past or historical fluid delivery data and/or personal parameters of a user are disclosed. Devices, and corresponding systems and methods, may comprise a dispensing unit configured to deliver a fluid from a reservoir into the body of a user and a processor having instructions operating thereon to retrieve data relating to one or more time windows from a memory, assess a correction delivery for the one or more time windows based on the data, determine a new CIR value for the one or more time windows if the correction delivery regularly follows a meal bolus and/or determine a new basal delivery profile for the one or more time windows if the correction delivery regularly precedes a meal bolus.

Abstract: Disclosed are systems, devices, and methods, including a system that includes a processor-based device implementing at least a residual insulin (RI) determination unit configured to determine a residual insulin in the patient's body at a particular time instance based on bolus doses previously delivered to the body of the patient, each bolus dose being associated with at least one dose value and a time representative of the time that dose value was delivered to the patient's body, and based on dose dependent RI time records that each includes at least a dose value and an associated duration value representative of dose-dependent duration of therapeutic effectiveness of the associated at least the dose value. The system also includes a pump to controllably dispense the insulin from a reservoir to the body of the patient based on the residual insulin determined by the RI determination unit.

Abstract: The present disclosure presents systems, devices and methods for administration of a therapeutic fluid to the body of a patient at a transient basal delivery profile, and enabling modification of the transient profile. Some embodiments include a user interface enabling input of one or more transient basal related parameters, and a processor having a basal programming application operating thereon. The basal programming application configured for determining a transient basal profile based on at least one or more transient basal related parameters. The transient basal profile comprises a plurality of phases and wherein each of the plurality of phases is characterized by a duration and at least one basal rate. In some embodiments, at least one of the plurality of phases includes either a basal overshot or a basal undershot. Some embodiments may also include a pump for dispensing the therapeutic fluid from a reservoir to the body of the patient.

Abstract: Disclosed is a system to deliver insulin to a user's body. The system includes a dispensing unit to deliver the insulin to the body, and a control mechanism to control delivery of basal insulin according to a predetermined basal infusion pattern, the basal infusion pattern selected from a plurality of predetermined basal infusion patterns. In some embodiments, selection of the basal infusion pattern may be based on one or more personal characteristics of the user.

Abstract: Embodiments of the present disclosure are directed to systems, devices/apparatuses and methods for assessing a residual insulin value for a user/patient. Such embodiments may be implemented by selecting a first value corresponding to a duration of insulin action; selecting a second value corresponding to a lock out time duration, selecting a first time period beginning at a time point T0 minus the first value and ending at the time point T0 minus the second value, selecting one or more boluses delivered during the first time period; for each of the one or more boluses selecting a corresponding residual insulin value estimated at the time point T0, computing the cumulative residual insulin value by summation of the corresponding residual insulin values.

Abstract: Disclosed is a system to deliver insulin to a user's body. The system includes a dispensing unit to deliver the insulin to the body, and a control mechanism to control delivery of basal insulin according to a predetermined basal infusion pattern, the basal infusion pattern selected from a plurality of predetermined basal infusion patterns. In some embodiments, selection of the basal infusion pattern may be based on one or more personal characteristics of the user.

Abstract: Methods and devices for delivering therapeutic fluid to the body are described. The method may include determining a bolus delivery pattern based on a specific dietary intake of a patient and delivering the therapeutic fluid into the patient's body based, at least in part, on the determined bolus delivery pattern. The devices used in conjunction with the disclosed methods may include a controller to determine a bolus delivery pattern based on a specific dietary intake of the patient and an infusion pump to deliver the therapeutic fluid into the patient's body based, at least in part, on the determined bolus delivery pattern.

Abstract: Products and methods directed to the improved infusion of fluids are disclosed. Such products and methods can be used to more efficiently and efficaciously administer therapeutic pharmaceuticals to a subject in need of treatment. In many instances, the systems comprise a therapeutic fluid delivery system and a mechanism for enhancing the absorption of the therapeutic fluid. The enhancement of the absorption of the therapeutic fluid is generally performed locally i.e., at or near the site of administration of the therapeutic fluid. The system and methods can be used to deliver any number of therapeutic fluids including but not limited to insulin.

Abstract: Methods, systems and devices for sustained medical infusion of fluids are described. Some implementations describe portable infusion methods, systems and devices for selecting a pattern of fluid delivery. Some implementations describe skin securable insulin dispensing methods, systems and devices for selecting a delivery pattern according to the nutritional characteristics (e.g. glycemic index, GI, fat content, etc.) of caloric intake of the user.

Abstract: Embodiments of the present disclosure include methods, systems and devices for selecting a bolus configuration and may include one or more of providing a user interface for selection of one or more user interface elements, where each element corresponds to a bolus configuration of a drug, each element is spatially positioned within a multi-dimensional space corresponding to at least three dimensions and the element's position corresponding to each dimension.

Abstract: Embodiments of the present disclosure are directed to methods, systems and devices for alleviating postprandial hyperglycemia, as well as to methods and devices for sustained medical infusion of fluids, using, for example, skin securable insulin dispensing systems/devices.