Patents by Inventor Galia Maik-Rachline

Galia Maik-Rachline has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Variants of pigment epithelium derived factor and uses thereof
    Patent number: 8530416
    Abstract: The present invention provides anti-angiogenic variants of pigment epithelium derived factor (PEDF) comprising at least one altered phosphorylation site, polynucleotides encoding same and uses thereof. Particularly, the present invention provides variants of human PEDF comprising at least one amino acid substitution at serine residues (24), (114), and (227). The PEDF variants are potent anti-angiogenic factors, and thus useful in treating diseases or disorders associated with neovascularization.
    Type: Grant
    Filed: April 3, 2012
    Date of Patent: September 10, 2013
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Rony Seger, Galia Maik-Rachline
  • VARIANTS OF PIGMENT EPITHELIUM DERIVED FACTOR AND USES THEREOF
    Publication number: 20120184481
    Abstract: The present invention provides anti-angiogenic variants of pigment epithelium derived factor (PEDF) comprising at least one altered phosphorylation site, polynucleotides encoding same and uses thereof. Particularly, the present invention provides variants of human PEDF comprising at least one amino acid substitution at serine residues (24), (114), and (227). The PEDF variants are potent anti-angiogenic factors, and thus useful in treating diseases or disorders associated with neovascularization.
    Type: Application
    Filed: April 3, 2012
    Publication date: July 19, 2012
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. at the Weizmann Institute of Science
    Inventors: Rony Seger, Galia Maik-Rachline
  • Variants of pigment epithelium derived factor and uses thereof
    Patent number: 8173591
    Abstract: The present invention provides anti-angiogenic variants of pigment epithelium derived factor (PEDF) comprising at least one altered phosphorylation site, polynucleotides encoding same and uses thereof. Particularly, the present invention provides variants of human PEDF comprising at least one amino acid substitution at serine residues (24), (114), and (227). The PEDF variants are potent anti-angiogenic factors, and thus useful in treating diseases or disorders associated with neovascularization.
    Type: Grant
    Filed: November 16, 2004
    Date of Patent: May 8, 2012
    Assignee: Yeda Research and Development Co.
    Inventors: Rony Seger, Galia Maik-Rachline
  • Variants of pigment epithelium derived factor and uses thereof
    Patent number: 8106010
    Abstract: The present invention relates to anti-angiogenic variants of pigment epithelium derived factor (PEDF) comprising a plurality of altered phosphorylation sites, polynucleotides encoding same and uses thereof. In particular, the PEDF variants of the present invention provide superior anti-angiogenic activity and high neurotrophic activity and are useful in treating diseases associated with neovascularization and with neurodegenerative conditions.
    Type: Grant
    Filed: November 14, 2006
    Date of Patent: January 31, 2012
    Assignee: Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science
    Inventors: Galia Maik-Rachline, Rony Seger
  • VARIANTS OF PIGMENT EPITHELIUM DERIVED FACTOR AND USES THEREOF
    Publication number: 20090269320
    Abstract: The present invention provides anti-angiogenic variants of pigment epithelium derived factor (PEDF) comprising at least one altered phosphorylation site, polynucleotides encoding same and uses thereof. Particularly, the present invention provides variants of human PEDF comprising at least one amino acid substitution at serine residues (24), (114), and (227). The PEDF variants are potent anti-angiogenic factors, and thus useful in treating diseases or disorders associated with neovascularization.
    Type: Application
    Filed: November 16, 2004
    Publication date: October 29, 2009
    Applicant: Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science
    Inventors: Rony Seger, Galia Maik-Rachline
  • Variants of Pigment Epithelium Derived Factor and Uses Thereof
    Publication number: 20080274967
    Abstract: The present invention relates to anti-angiogenic variants of pigment epithelium derived factor (PEDF) comprising a plurality of altered phosphorylation sites, polynucleotides encoding same and uses thereof. In particular, the PEDF variants of the present invention provide superior anti-angiogenic activity and high neurotrophic activity and are useful in treating diseases associated with neovascularization and with neurodegenerative conditions.
    Type: Application
    Filed: November 14, 2006
    Publication date: November 6, 2008
    Inventors: Galia Maik-Rachline, Rony Seger