Abstract: An interactive clinical decision support system and method is presented. The support system includes a mobile device, a database having up-to-date medical guidelines, and a network. The support system may further include one or more sensors configured to provide patient information. The interactive method includes steps of calculating scores based on clinical studies, which use patient information to generate an initial management plan recommendation and management plan rating. The method further includes a clinician discretion factor to balance benefits, risks, burdens, and costs of obtaining unknown patient information. A significance value of each patient information which may result in a management plan with a stronger recommendation, is calculated and ranked according to the clinician discretion factor. A set of unknown patient information is presented as options for creating a clinical order that will be executed once selected.