Patents by Inventor Galina F. DENISOVA

Galina F. DENISOVA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • T cell-antigen coupler with Y182T mutation and methods of uses thereof
    Patent number: 11970545
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Grant
    Filed: March 22, 2023
    Date of Patent: April 30, 2024
    Assignee: McMaster University
    Inventors: Christopher W. Helsen, Jonathan Bramson, Anna Dvorkin-Gheva, Galina F. Denisova, Ksenia Bezverbnaya, Kenneth Anthony Mwawasi
  • T CELL-ANTIGEN COUPLER WITH Y182T MUTATION AND METHODS OF USES THEREOF
    Publication number: 20230265207
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Application
    Filed: March 22, 2023
    Publication date: August 24, 2023
    Inventors: Christopher W. Helsen, Jonathan Bramson, Anna Dvorkin-Gheva, Galina F. Denisova, Ksenia Bezverbnaya, Kenneth Anthony Mwawasi
  • T cell-antigen coupler with Y182T mutation and methods and uses thereof
    Patent number: 11643472
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: May 9, 2023
    Assignee: McMaster University
    Inventors: Christopher W. Helsen, Jonathan Bramson, Anna Dvorkin-Gheva, Galina F. Denisova, Ksenia Bezverbnaya, Kenneth Anthony Mwawasi
  • T cell-antigen coupler with Y177 mutation and methods of uses thereof
    Patent number: 11198737
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y177 mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: December 14, 2021
    Assignee: McMaster University
    Inventors: Christopher W. Helsen, Jonathan Bramson, Anna Dvorkin-Gheva, Galina F. Denisova, Ksenia Bezverbnaya, Kenneth Anthony Mwawasi
  • T CELL-ANTIGEN COUPLER WITH Y182T MUTATION AND METHODS AND USES THEREOF
    Publication number: 20200392247
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Application
    Filed: October 10, 2018
    Publication date: December 17, 2020
    Inventors: Christopher W. HELSEN, Jonathan BRAMSON, Anna DVORKIN-GHEVA, Galina F. DENISOVA, Ksenia BEZVERBNAYA, Kenneth Anthony MWAWASI