Abstract: This invention relates to apparatus and method for detection of human skin lesion malignancy. The method relies on two independent wavelengths regions: (a) visible and Near IR circa (0.4-1.3 um); (b) Far Infrared (6-12 um). The visible and NIR wavelengths will analyze sub-skin scattering and absorbance to detect structural and diffusion abnormalities, and the FIR wavelengths will monitor the thermal blood perfusion, as reflected by monitoring temperature variation of suspected region. An apparatus according to the present invention would comprise a cooling/heating component which encloses the suspected area, MIR camera or thermal sensors, visible and NIR camera. Evaluation of the rate of the skin temperature changes and propagation in the suspected area will enable to detect increased blood perfusion and metabolic heat, identifying alarming signals related to skin diseases. Parallelly, the sub-skin density and coagulation will be analyzed by peripheral illumination.