Patents by Inventor Gan Xi

Gan Xi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-PD-1/CD47 bispecific antibody and application thereof
    Patent number: 11680099
    Abstract: The present invention provides a recombinant protein. The recombinant protein includes an anti-PD-1 antibody and human SIRPA extracellular domain. The N-terminus of the human SIRPA extracellular domain is linked to the C-terminus of the heavy chain of the anti-PD-1 antibody.
    Type: Grant
    Filed: June 4, 2020
    Date of Patent: June 20, 2023
    Assignee: HANX BIOPHARMACEUTICS, INC
    Inventors: Ying Huang, Faming Zhang, Gan Xi
  • Anti-PD-1 monoclonal antibody
    Patent number: 11104734
    Abstract: Proposed is an anti-PD-1 monoclonal antibody or an antigen binding fragment thereof, comprising a heavy chain variable region having at least one of the amino acid sequences listed below: (1) the amino acid sequence shown in SEQ ID NO: 1; (2) the amino acid sequence shown in SEQ ID NO: 3; (3) the amino acid sequence shown in SEQ ID NO: 5; and (4) an amino acid sequence having more than one conservative amino acid mutation compared with (1)-(3).
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: August 31, 2021
    Assignees: Akeso Biopharma, Inc., Taizhou Hanzhong Biopharmaceutics, Inc.
    Inventors: Yu Xia, Baiyong Li, Zhongmin Maxwell Wang, Faming Zhang, Gan Xi, Ying Huang
  • Monoclonal antibody against PD-1 and application thereof
    Patent number: 10858433
    Abstract: Provided is a monoclonal antibody against programmed death-1 (PD-1) or applications thereof, where the monoclonal antibody against PD-1 comprises a neonatal Fc Receptor (FcRn)-binding site having an amino acid sequence of SEQ ID NO: 5.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: December 8, 2020
    Assignees: Taizhou Hanzhong Biopharmaceutics, Inc., Akeso Biopharma, Inc.
    Inventors: Faming Zhang, Gan Xi, Ying Huang, Yu Xia, Baiyong Li, Zhongmin Maxwell Wang
  • ANTI-PD-1/CD47 BISPECIFIC ANTIBODY AND APPLICATION THEREOF
    Publication number: 20200291118
    Abstract: The present invention provides a recombinant protein. The recombinant protein includes an anti-PD-1 antibody and human SIRPA extracellular domain. The N-terminus of the human SIRPA extracellular domain is linked to the C-terminus of the heavy chain of the anti-PD-1 antibody.
    Type: Application
    Filed: June 4, 2020
    Publication date: September 17, 2020
    Inventors: Ying Huang, Faming ZHANG, Gan Xi
  • MONOCLONAL ANTIBODY AGAINST PD-1 AND APPLICATION THEREOF
    Publication number: 20190330347
    Abstract: Provided is a monoclonal antibody against programmed death-1 (PD-1) or applications thereof, where the monoclonal antibody against PD-1 comprises a neonatal Fc Receptor (FcRn)-binding site having an amino acid sequence of SEQ ID NO: 5.
    Type: Application
    Filed: July 12, 2019
    Publication date: October 31, 2019
    Inventors: Faming ZHANG, Gan XI, Ying HUANG, Yu XIA, Baiyong LI, Zhongmin Maxwell WANG
  • METHOD FOR INCREASING BINDING AFFINITY OF IGG-LIKE ANTIBODY TO FCRN AND PROLONGING SERUM HALF-LIFE THEREOF
    Publication number: 20190330313
    Abstract: Provided a method for increasing binding affinity of an IgG-like antibody to FcRn and prolonging serum half-life thereof The method comprises mutating amino acids at positions 254, 308 and 434 in an FcRn-binding site of a heavy chain constant region of the IgG-like antibody.
    Type: Application
    Filed: July 12, 2019
    Publication date: October 31, 2019
    Inventors: Faming ZHANG, Gan XI, Ying HUANG
  • Anti-PD-1 monoclonal antibody
    Publication number: 20190040138
    Abstract: Proposed is an anti-PD-1 monoclonal antibody or an antigen binding fragment thereof, comprising a heavy chain variable region having at least one of the amino acid sequences listed below: (1) the amino acid sequence shown in SEQ ID NO: 1; (2) the amino acid sequence shown in SEQ ID NO: 3; (3) the amino acid sequence shown in SEQ ID NO: 5; and (4) an amino acid sequence having more than one conservative amino acid mutation compared with (1)-(3).
    Type: Application
    Filed: September 28, 2018
    Publication date: February 7, 2019
    Inventors: Yu Xia, Baiyong Li, Zhongmin Maxwell Wang, Faming Zhang, Gan Xi, Ying Huang