Abstract: The subject matter disclosed herein is directed to modulating gene expression using siRNA compositions and methods directed to affecting key cell populations supporting the growth and metastasis of cancer to affect the beneficial treatment, remission or removal of the underlying tumor in a patient.

Abstract: For each retailer in the geographic region, an online system predicts a number of orders placed at the retailer and a capacity to fulfill orders during a forecast time period. The capacity of the retailer is predicted based on a number of pickers expected to be available to the retailer during the forecast time period. The online system determines demand for the services of a picker at the retailer based on a comparison of the predicted number of orders and the predicted capacity to fulfill those orders. The online system displays a user interactive map of the geographic region to the picker. The map displays a pin at the location of each retailer in the geographic region, which describes the categorization determined for the retailer. The picker selects a pin, which causes the user interactive map to display a notification characterizing the demand for services at the retailer.

Abstract: An online concierge system allows users to order items within discrete time intervals later than a time when an order was received or for short-term fulfillment when the order was received. To account for a number of shoppers available to fulfill orders during different discrete time intervals and numbers of orders for fulfillment during different discrete time intervals, the online concierge system specifies a target rate for orders fulfilled later than a specified discrete time interval and a threshold from the target rate. A trained machine learning model periodically predicts a percentage of orders being fulfilled late, with an order associated with a predicted percentage when the order was received. The online concierge system increases a price of orders associated with predicted percentages greater than the threshold from the target rate. The increased price of an order is determined from a price elasticity curve and the predicted percentage.

Abstract: An online concierge system provides arrival prediction services for a user placing an order to be retrieved by a shopper. An order may have a predicted arrival time predicted by a model that may err under some conditions. To reduce the likelihood of providing the predicted arrival time (and related services) when the arrival time may be incorrect, the prediction model and related services are throttled (e.g., selectively provided) based on one or more predicted delivery metrics, which may include a time to accept the order by a shopper and a predicted portion of late orders that will be delivered past the respective predicted arrival times. The predicted delivery metrics are compared with thresholds and the result of the comparison used to selectively provide, or not provide, the predicted delivery services.

Abstract: An online system accesses a machine learning model trained to predict behaviors of users of the online system, in which the model is trained based on historical data received by the online system that is associated with the users and demand and supply sides associated with the online system. The online system identifies a treatment for achieving a goal of the online system and simulates application of the treatment on the demand and supply sides based on the historical data and a set of behaviors predicted for the users. Application of the treatment is simulated by replaying the historical data in association with application of the treatment and applying the model to predict the set of behaviors while replaying the data. The online system measures an effect of application of the treatment on the demand and supply sides based on the simulation, in which the effect is associated with the goal.

Abstract: An online concierge system includes a marketplace automation engine for setting various control parameters affecting marketplace operation. The marketplace automation engine applies a hyperparameter learning model to the marketplace state data to predict a set of hyperparameters affecting a set of respective parameterized control decision models. The hyperparameter learning model is trained on historical marketplace state data and a configured outcome objective for the online concierge system. The marketplace automation engine independently applies the set of parameterized control decision models to the marketplace state data using the hyperparameters to generate a respective set of control parameters affecting marketplace operation of the online concierge system. The marketplace automation engine applies the respective set of control parameters to operation of the online concierge system.

Abstract: For each retailer in the geographic region, an online system predicts a number of orders placed at the retailer and a capacity to fulfill orders during a forecast time period. The capacity of the retailer is predicted based on a number of pickers expected to be available to the retailer during the forecast time period. The online system determines demand for the services of a picker at the retailer based on a comparison of the predicted number of orders and the predicted capacity to fulfill those orders. The online system displays a user interactive map of the geographic region to the picker. The map displays a pin at the location of each retailer in the geographic region, which describes the categorization determined for the retailer. The picker selects a pin, which causes the user interactive map to display a notification characterizing the demand for services at the retailer.

Abstract: An online concierge system allows users to order items within discrete time intervals later than a time when an order was received or for short-term fulfillment when the order was received. To account for a number of shoppers available to fulfill orders during different discrete time intervals and numbers of orders for fulfillment during different discrete time intervals, the online concierge system specifies a target rate for orders fulfilled later than a specified discrete time interval and a threshold from the target rate. A trained machine learning model periodically predicts a percentage of orders being fulfilled late, with an order associated with a predicted percentage when the order was received. The online concierge system increases a price of orders associated with predicted percentages greater than the threshold from the target rate. The increased price of an order is determined from a price elasticity curve and the predicted percentage.

Abstract: An online concierge system assigns shoppers to fulfill orders from users. To allocate shoppers, the online concierge system predicts future supply and demand for the shoppers' services for different time windows. To forecast a supply of shoppers, the online concierge system trains a machine learning model that estimates future supply based on access to a shopper mobile application through which the shoppers obtain new assignments by shoppers. The online concierge system also forecasts future orders. The online concierge system estimates a supply gap in a future time period by selecting a target time to accept for shoppers to accept orders and determining a corresponding ratio of number of shoppers and number of orders. The online concierge system may adjust a number of shoppers allocated to the future time period to achieve the determined ratio number of shoppers and number of orders.

Abstract: A system, method, and computer-readable storage medium is provided for creating first and second blockchain instances, each comprising representative blocks corresponding to steps in first and second multistep processes, respectively; performing a linking operation to link a block in the first blockchain instance to a block in the second blockchain instance; receiving change evidence data pertaining to steps in one of the first and second multi-step processes; and performing an update operation comprising updating one of the first and second blockchain instances based on said change evidence data.

Abstract: A system, method, and computer-readable storage medium is provided for creating first and second blockchain instances, each comprising representative blocks corresponding to steps in first and second multistep processes, respectively; performing a linking operation to link a block in the first blockchain instance to a block in the second blockchain instance; receiving change evidence data pertaining to steps in one of the first and second multi-step processes; and performing an update operation comprising updating one of the first and second blockchain instances based on said change evidence data.

Abstract: An online concierge system trains a machine learning conversion model that predicts a probability of receiving an order from a user when the user accesses the online concierge system. The conversion model predicts the probability of receiving the order based on a set of input features that include price and availability information. For each access to the online concierge system, the online concierge system applies the conversion model to a current price and availability and to an optimal price availability. The online concierge system generates a metric as the difference between the two predicted probabilities of receiving an order.

Abstract: An online concierge system trains a machine learning conversion model that predicts a probability of receiving an order from a user when the user accesses the online concierge system. The conversion model predicts the probability of receiving the order based on a set of input features that include price and availability information. For each access to the online concierge system, the online concierge system applies the conversion model to a current price and availability and to an optimal price availability. The online concierge system generates a metric as the difference between the two predicted probabilities of receiving an order.

Abstract: An online concierge system trains a machine learning conversion model that predicts a probability of receiving an order from a user when the user accesses the online concierge system. The conversion model predicts the probability of receiving the order based on a set of input features that include price and availability information. For each access to the online concierge system, the online concierge system applies the conversion model to a current price and availability and to an optimal price availability. The online concierge system generates a metric as the difference between the two predicted probabilities of receiving an order.

Abstract: An online concierge system allows users to order items within discrete time intervals later than a time when an order was received or for short-term fulfillment when the order was received. To account for a number of shoppers available to fulfill orders during different discrete time intervals and numbers of orders for fulfillment during different discrete time intervals, the online concierge system specifies a target rate for orders fulfilled later than a specified discrete time interval and a threshold from the target rate. A trained machine learning model periodically predicts a percentage of orders being fulfilled late, with an order associated with a predicted percentage when the order was received. The online concierge system increases a price of orders associated with predicted percentages greater than the threshold from the target rate. The increased price of an order is determined from a price elasticity curve and the predicted percentage.

Abstract: A system, method, and computer-readable storage medium is provided for creating first and second blockchain instances, each comprising representative blocks corresponding to steps in first and second multistep processes, respectively; performing a linking operation to link a block in the first blockchain instance to a block in the second blockchain instance; receiving change evidence data pertaining to steps in one of the first and second multi-step processes; and performing an update operation comprising updating one of the first and second blockchain instances based on said change evidence data.

Abstract: For each retailer in the geographic region, an online system predicts a number of orders placed at the retailer and a capacity to fulfill orders during a forecast time period. The capacity of the retailer is predicted based on a number of pickers expected to be available to the retailer during the forecast time period. The online system determines demand for the services of a picker at the retailer based on a comparison of the predicted number of orders and the predicted capacity to fulfill those orders. The online system displays a user interactive map of the geographic region to the picker. The map displays a pin at the location of each retailer in the geographic region, which describes the categorization determined for the retailer. The picker selects a pin, which causes the user interactive map to display a notification characterizing the demand for services at the retailer.

Abstract: A system, method, and computer-readable storage medium is provided for creating a blockchain instance and aligning the instance blockchain to a generic blockchain for tracking a multi-step process. Aspects of the invention comprise performing by a blockchain system: accessing data for the creation of a block in a blockchain instance; comparing said data with data associated with a block in a generic blockchain; and for each block in the generic blockchain where the data in the block corresponds to the accessed data, creating a block in the blockchain instance for the accessed data; and performing an alignment operation to indicate that the created block is equivalent to the block in the generic blockchain.

Abstract: A system, method, and computer-readable storage medium is provided for storing, in a blockchain system, at least one generic finite blockchain comprising representative blocks, each corresponding to at least one step in a multi-step process; dynamically generating at least one finite blockchain instance based on said at least one generic finite blockchain; receiving, by a processor, change evidence data pertaining to at least one step in said multi-step process; and performing an update operation comprising updating the at least one finite blockchain instance based on said change evidence data.

Abstract: A system, method, and computer-readable storage medium is provided for creating first and second blockchain instances, each comprising representative blocks corresponding to steps in first and second multistep processes, respectively; performing a linking operation to link a block in the first blockchain instance to a block in the second blockchain instance; receiving change evidence data pertaining to steps in one of the first and second multi-step processes; and performing an update operation comprising updating one of the first and second blockchain instances based on said change evidence data.