Patents by Inventor Ganesh Venkataraman

Ganesh Venkataraman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND PRODUCTS RELATED TO LOW MOLECULAR WEIGHT HEPARIN
    Publication number: 20130017565
    Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
    Type: Application
    Filed: May 7, 2012
    Publication date: January 17, 2013
    Applicant: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • MOUNTING MODULES FOR A DC DISTRIBUTION ASSEMBLY
    Publication number: 20130016455
    Abstract: A mounting module for a DC distribution assembly is provided. The module includes a base portion that holds at least first and second electrically conductive straps thereon. The straps are disposed on and coupled to the electrically non-conductive base portion. The module further includes a first breaker pole assembly having a first line side electrically coupled to the first electrically conductive strap. The mounting module further includes a second breaker pole assembly having a second line side electrically coupled to the second electrically conductive strap.
    Type: Application
    Filed: July 13, 2011
    Publication date: January 17, 2013
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Brian Frederick Mooney, Mariusz Duda, Nicholas Ryan Goodine, Eric Duane Rowland, Ganesh Venkataraman, Michael Richard Wood
  • Methods related to cell surface glycosylation
    Patent number: 8338088
    Abstract: The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins.
    Type: Grant
    Filed: April 15, 2008
    Date of Patent: December 25, 2012
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Brian Edward Collins, Carlos J. Bosques, Xiangping Zhu, Dorota A. Bulik, Lakshmanan Thiruneelakantapillai, Ian Christopher Parsons, Zachary Shriver, Rajeev Chillakuru, Ganesh Venkataraman
  • Methods for analyzing or processing a heparin sample
    Patent number: 8173384
    Abstract: The invention relates to methods and products for analyzing or processing a heparin sample. In one embodiment, the methods comprise contacting the sample with heparinase I, heparinase II and heparinase III, determining the amount of a signature component in the sample using a separation method, and making a determination about the sample based upon a comparison of the amount of the signature component in the sample to a reference database for a heparin.
    Type: Grant
    Filed: July 27, 2009
    Date of Patent: May 8, 2012
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • DELTA 4, 5 GLYCURONIDASE COMPOSITIONS AND METHODS RELATED THERETO
    Publication number: 20120045425
    Abstract: The invention relates to ?4,5 glycuronidase, related compositions, and methods of use thereof.
    Type: Application
    Filed: April 8, 2011
    Publication date: February 23, 2012
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: JAMES R. MYETTE, ZACHARY SHRIVER, GANESH VENKATARAMAN, RAM SASISEKHARAN, MAITLAND W. MCLEAN
  • MODIFIED HEPARINASE III AND METHODS OF SEQUENCING THEREWITH
    Publication number: 20120027744
    Abstract: The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
    Type: Application
    Filed: March 30, 2011
    Publication date: February 2, 2012
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: DONGFANG LIU, KEVIN POJASEK, ZACHARY SHRIVER, KRISTINE HOLLEY, YOSUF EL-SHABRAWI, GANESH VENKATARAMAN, RAM SASISEKHARAN
  • Methods of evaluating mixtures of polysaccharides
    Patent number: 8101733
    Abstract: Methods for analyzing mixtures of polysaccharides, for example heparin or a LMWH, using reduce end labeling are described. In general, the mixture of polysaccharides includes polysaccharides having a desired structural moiety. In some instances, one or more polysaccharides in the mixture are chemically modified prior to analysis.
    Type: Grant
    Filed: June 27, 2006
    Date of Patent: January 24, 2012
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Zachary Shriver, Cuihua Liu, Nur Sibel Gunay, Ishan Capila, Ganesh Venkataraman
  • ANALYSIS OF SULFATED POLYSACCHRIDES
    Publication number: 20110288046
    Abstract: The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.
    Type: Application
    Filed: April 13, 2011
    Publication date: November 24, 2011
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: GANESH VENKATARAMAN, ZACHARY SHRIVER, MALIKARJUN SUNDARAM, YI-WEI QI, RAM SASISEKHARAN
  • Method for sequence determination using NMR
    Patent number: 8018231
    Abstract: The invention relates to methods for analyzing polysaccharides. In particular, compositional and sequence information about the polysaccharides are derived. Some methods use NMR in conjunction with another experimental method, such as, capillary electrophoretic techniques for the analysis.
    Type: Grant
    Filed: May 5, 2010
    Date of Patent: September 13, 2011
    Assignees: Massachussetts Institute of Technology, Istituto di Ricerche Chimiche e Biochimiche G Ronzoni
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Rahul Raman, Benito Casu, Giangiacomo Torri, Marco Guerrini
  • SACCHARIDE STRUCTURES AND METHODS OF MAKING AND USING SUCH STRUCTURES
    Publication number: 20110201801
    Abstract: Described are oligosaccharides having a protecting group at two, a plurality, a majority of, or each position in the oligosaccharide which is amenable to derivatization. Collections, libraries and methods of making and using such oligosaccharides are also described.
    Type: Application
    Filed: May 29, 2009
    Publication date: August 18, 2011
    Applicant: MOMENTA PHARAMACEUTICALS, INC.
    Inventors: Sucharita Roy, Takashi Kei Kishimoto, Ganesh Venkataraman
  • Delta 4,5 glycuronidase compositions and methods related thereto
    Patent number: 7951560
    Abstract: The invention relates to ?4,5 glycuronidase, related compositions, and methods of use thereof.
    Type: Grant
    Filed: November 11, 2009
    Date of Patent: May 31, 2011
    Assignee: Massachusetts Institute of Technology
    Inventors: James R. Myette, Zachary Shriver, Ganesh Venkataraman, Ram Sasisekharan, Maitland W. McLean
  • Analysis of sulfated polysaccharides
    Patent number: 7947507
    Abstract: The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.
    Type: Grant
    Filed: September 3, 2008
    Date of Patent: May 24, 2011
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Ganesh Venkataraman, Zachary Shriver, Mallikarjun Sundaram, Yi Wei Qi, Ram Sasisekharan
  • Modified heparinase III and methods of sequencing therewith
    Patent number: 7939292
    Abstract: The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: May 10, 2011
    Assignee: Massachusetts Institute of Technology
    Inventors: Dongfang Liu, Kevin Pojasek, Zachary Shriver, Kristine Holley, Yosuf El-Shabrawi, Ganesh Venkataraman, Ram Sasisekharan
  • METHODS OF MAKING LOW MOLECULAR WEIGHT HEPARIN COMPOSITIONS
    Publication number: 20110076729
    Abstract: Methods of making LMWH compositions are provided to provide the LMWH compositions at a yield of at least about 10%.
    Type: Application
    Filed: February 19, 2009
    Publication date: March 31, 2011
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Zainab Sirajbhai Mamuwala, Ganesh Venkataraman
  • LOW MOLECULAR WEIGHT HEPARIN COMPOSITION AND USES THEREOF
    Publication number: 20100305022
    Abstract: Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.
    Type: Application
    Filed: May 26, 2010
    Publication date: December 2, 2010
    Inventors: Zachary Shriver, Mallikarjun Sundaram, Ganesh Venkataraman, Pat Oliver-Shaffer, Yiming Yao, Zainab Sirajbhai Mamuwala, Ian David Fier, Yiwei Qi, Ishan Capila, Nur Sibel Gunay, Daniela Beccati, Cuihua Liu, Corinne Bauer, Ying Li
  • NOVEL METHOD FOR SEQUENCE DETERMINATION USING NMR
    Publication number: 20100216176
    Abstract: The invention relates to methods for analyzing polysaccharides. In particular, compositional and sequence information about the polysaccharides are derived. Some methods use NMR in conjunction with another experimental method, such as, capillary electrophoretic techniques for the analysis.
    Type: Application
    Filed: May 5, 2010
    Publication date: August 26, 2010
    Applicants: Massachusetts Institute of Technology, Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni
    Inventors: RAM SASISEKHARAN, Ganesh Venkataraman, Rahul Raman, Benito Casu, Giangiacomo Torri, Marco Guerrini
  • METHODS RELATED TO CELL SURFACE GLYCOSYLATION
    Publication number: 20100196940
    Abstract: The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins.
    Type: Application
    Filed: April 15, 2008
    Publication date: August 5, 2010
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Brian Edward Collins, Carlos J. Bosques, Xiangping Zhu, Dorota A. Bulik, Lakshmanan Thiruneelakantapillai, Ian Christopher Parsons, Zachary Shriver, Rajeev Chillakuru, Ganesh Venkataraman
  • Method for sequence determination using NMR
    Patent number: 7737692
    Abstract: The invention relates to methods for analyzing polysaccharides. In particular, compositional and sequence information about the polysaccharides are derived. Some methods use NMR in conjunction with another experimental method, such as, capillary electrophoretic techniques for the analysis.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: June 15, 2010
    Assignees: Massachusetts Institute of Technology, Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Rahul Raman, Benito Casu, Giangiacomo Torri, Marco Guerrini
  • Method for sequence determination using NMR
    Patent number: 7728589
    Abstract: The invention relates to methods for analyzing polysaccharides. In particular, compositional and sequence information about the polysaccharides are derived. Some methods use NMR in conjunction with another experimental method, such as, capillary electrophoretic techniques for the analysis.
    Type: Grant
    Filed: June 24, 2008
    Date of Patent: June 1, 2010
    Assignees: Massachusetts Institute of Technology, Instituto di Ricerche Chimiche e Biochimiche G. Ronzoni
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Rahul Raman, Benito Casu, Giangiacomo Torri, Marco Guerrini
  • DELTA 4,5 GLYCURONIDASE COMPOSITIONS AND METHODS RELATED THERETO
    Publication number: 20100129868
    Abstract: The invention relates to ?4,5 glycuronidase, related compositions, and methods of use thereof.
    Type: Application
    Filed: November 11, 2009
    Publication date: May 27, 2010
    Applicant: Massachusetts Institute of Technology
    Inventors: James R. Myette, Zachary Shriver, Ganesh Venkataraman, Ram Sasisekharan, Maitland W. McLean