Abstract: The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TR? mutation.

Abstract: Provided in the present application is an ultrasonic imaging method, including: generating a plurality of anatomical plane schematics, and causing a display to display the same, each one of the plurality of anatomical plane schematics respectively corresponding to a different anatomical plane of interest; acquiring an ultrasonic image of the anatomical plane of interest; and automatically generating an ultrasonic image thumbnail of the anatomical plane of interest, automatically replacing the anatomical plane schematic corresponding to the anatomical plane of interest with the ultrasonic image thumbnail, and causing the display to display the same. Also provided in the present application are an ultrasonic imaging system and a non-transitory computer-readable medium.

Abstract: A clock distribution circuit includes a global distribution circuit, a first local distribution circuit and a second local distribution circuit. The global distribution circuit receives external clock signals and generates internal clock signals and primary reference clock signal set according to the external clock signals. The first local distribution circuit receives the internal clock signals and the primary reference clock signal set and generates a secondary reference clock signal set according to the internal clock signals and the primary reference clock signal set. The second local distribution circuit receives the internal clock signals and the secondary reference clock signal set and generates a thirdly reference clock signal set according to the internal clock signals and the secondary reference clock signal set.

Abstract: A method and system for positioning and correcting visual data by seafloor topographic profiles are provided. The method includes: offsetting the water-depth profile of the target survey line equidistantly in a grid layer of a target area to make profiles generated after the offsetting traverse the grid layer of the target area, and obtaining offset data sequences corresponding to the water-depth profile of the target survey line; drawing offset topographic profiles based on offset data of the offset data sequences corresponding to the water-depth profile of the target survey line; calculating a profile similarity between the water-depth profile of the target survey line and each of the offset topographic profiles by using a dynamic time warping (DTW) algorithm; and selecting a geographic location of one of the offset topographic profiles with a largest profile similarity as an actual geographic location of a water-depth profile of a seafloor visual survey line.

Abstract: Disclosed herein are heterocyclic compounds that may be used as STING modulators, the process for synthesis and to the use of such compounds in treatment of various diseases including cancers.

Abstract: Embodiments of the present disclosure relate to methods and devices for channel state information (CSI) transmission. In example embodiments, a method implemented in a terminal device includes performing a channel estimate between the terminal device and a network device across a predetermined frequency range for a set of beams having different spatial directions; determining, based on the channel estimate, first indication information indicating at least one beam selected from the set of beams and second indication information indicating frequency-related information for the at least one selected beam at a plurality of frequency locations in the predetermined frequency range; and transmitting to the network device the first indication information in a first part of a channel state information (CSI) report and the second indication information in a second part of the CSI report.

Abstract: The present invention provides an intelligent geophysical data acquisition system and acquisition method for shale oil and gas optical fiber. A pipe string is arranged in a metal casing, and an external armored optical cable is fixed outside the metal casing; an, internal armored optical cable is fixed outside the pipe string; the external armored optical cable comprises a downhole acoustic sensing optical cable, two multi-mode optical fibers, a strain optical cable and a pressure sensor array, and further comprises horizontal ground acoustic sensing optical cables arranged in the shallow part of the ground according to an orthogonal grid, and artificial seismic source excitation points arranged on the ground according to the orthogonal grid.

Abstract: The present disclosure relates to an organic light emitting display device and an organic light emitting display panel including color filters disposed on a substrate and overlapping an emission area, a first insulating layer disposed on the color filters, a first active layer disposed on the first insulating layer, a gate electrode disposed on an upper surface of the first active layer, a second insulating layer disposed on the first active layer and the gate electrode and comprising a hole exposing a portion of the upper surface of the first active layer, a bank disposed on the second insulating layer and comprising an opening overlapping the hole of the second insulating layer, an organic layer disposed on the portion of the upper surface of the first active layer and the bank, and a cathode electrode disposed on the organic layer, thereby providing the organic light emitting display device and the organic light emitting display panel that are capable of simplifying the process.

Abstract: The invention relates to a method for predicting benchmark value of unit equipment based on XGBoost algorithm and a system thereof, wherein the method comprises the following steps: the historical operation data of unit equipment is obtained, the data is preprocessed, and a data set containing a plurality of samples is constructed, and each sample includes the benchmark value of a plurality of parameters of the equipment corresponding to a plurality of features; RF out-of-bag estimation is used for feature importance calculation to eliminate the features with low importance; the data is standardized to eliminate the dimensional effects among features; the data set is input to construct an XGBoost model, and Bayesian super parameter optimization is conducted to obtain the prediction model of benchmark values; and the real-time data of equipment operation is input, and the benchmark values of various equipment parameters are predicted by the prediction model of benchmark values.

Abstract: An erection device and method for the marine hot launch of a rocket are provided. The erection device includes a launch vessel, a launch pad, an erection assembly, a guide member, a driving cylinder, a sliding member, and a connecting member. The sliding member cooperates with the guide member and is driven by the driving cylinder to move linearly. The connecting member has one end hinged to the erection assembly at a certain angle and the other end connected to the sliding member and is configured to move with the sliding member to drive the erection assembly to be erected on the launch pad. The erection device and method can achieve an effective erection of the rocket for marine hot launch with a desired erection effect and high stability.

Abstract: An embodiment detects, by a packet detection module on a first worker node, a first synchronization message (SYN) issued from a client pod on the first worker node and directed to a first server pod on a second worker node and generates a first SYN record in a connection table stored on the first worker node. The embodiment detects, by the packet detection module, a second SYN issued from the client pod and directed to the first server pod and generates a server pod status record stored in memory on the first worker node indicative of the first server pod having an unhealthy status. The embodiment identifies an available server pod having a healthy status and generates a detour routing rule in a routing table on the first worker node indicative of a revised connection in which the identified available server pod replaces the first server pod.

Abstract: A method and an apparatus for measuring temperature, and a computer-readable storage medium includes detecting a target position of an object in an input image; determining key points of the target position and weight information of each key point based on a detection result of the target position, in which the weight information is configured to indicate a probability of each key point being covered; acquiring temperature information of each key point; and determining a temperature of the target position at least based on the temperature information and the weight information of each key point.

Abstract: Systems and methods for presenting a qualitative risk assessment for an aircraft to perform a flight procedure. Methods include determining: a pilot support value that is representative of a human-machine interface (HMI) onboard the aircraft; a crew factors value representative of a number of pilots and respective experience; an equipment state value of the aircraft, representing available and functioning avionic systems; a type of procedure for the flight procedure; a remaining trip length; an airport facilities state value; an Airport facilities state value; a physical environment value; and, an environmental state value. The method calculates the qualitative risk assessment, as a function of the determined values/factors and presents the qualitative risk assessment in a predefined area on an avionic display in the aircraft.

Abstract: Disclosed are an electromagnet driving mechanism, an electromagnet driving assembly and a dual power automatic transfer switch. The electromagnet driving mechanism includes: a mechanism frame; a stationary core; a movable core, including a moving stroke between a first position away from the stationary core and a second position in contact with the stationary core, the moving stroke including an approaching stroke section; a coil, configured to generate a magnetic attraction force between the stationary core and the movable core upon being energized to drive the movable core to move towards the second position; a reset spring member; and a reset auxiliary assembly, including a push member and a reset auxiliary spring. The reset auxiliary assembly applies a reset auxiliary spring force to the movable core in the approaching stroke section through the push member.

Abstract: A light detection and ranging (LiDAR) system for scanning and reconfiguring regions-of-interest (ROIs) is provided. The system comprises a LiDAR scanner configured to scan a current set of ROIs within a field-of-view (FOV), and a LiDAR perception sub-system coupled to the LiDAR scanner. The LIDAR perception sub-system includes instructions for: obtaining sensor data provided at least by the LiDAR scanner; deriving one or more current perceptions based on the sensor data; obtaining one or more predefined perception policies; determining one or more policy-based ROI candidates; determining whether an ROI reconfiguration request is provided, based on a vehicle perception decision; determining one or more request-based ROI candidates based on the ROI reconfiguration request; and determining a next set of ROIs for the LiDAR scanner to scan based on the current set of ROIs, and one or both of the one or more policy-based ROI candidates and the one or more request-based ROI candidates.

Abstract: This disclosure relates to a privacy preserving machine learning platform. In one aspect, a method includes receiving, by a first computing system of multiple multi-party computation (MPC) systems, an inference request that includes a first share of a given user profile. A number k of nearest neighbor user profiles that are considered most similar to the given user profile are identified. The first computing system identifies a first set of nearest neighbor profiles based on the first share of the given user profile and a k-nearest neighbor model. The first computing system receives, from each of one or more second computing systems of the multiple MPC systems, data indicating a respective second set of nearest neighbor profiles identified by the second computing system based on a respective second share of the given user profile and a respective second k-nearest neighbor model trained by the second computing system.

Abstract: Embodiments of the present disclosure provide method, device and computer readable medium for beam failure recovery. In example embodiments, a method implemented at a terminal device is provided. The method comprises determining a configuration for receiving Physical Downlink Control Channels (PDCCHs) from a network device, the network device communicating with the terminal device via first and second Transmission and Reception Points (TRPs), wherein the configuration indicates which one of the first and second TRPs are the PDCCHs to be received from. The method further comprises determining whether a beam failure occurs in at least one of the first and second TRPs. In addition, the method further comprises, in response to determining that a beam failure occurs in at least one of the first and second TRPs, performing beam failure recovery (BFR) for the first and second TRPs at least based on the configuration.

Abstract: The disclosure relates to poly alpha-1,6-glucan derivatives comprising poly alpha-1,6-glucan substituted with at least one organic group linked to the poly alpha-1,6-glucan through a linkage moiety selected from ether, sulfonyl, carbonate, or carbamoyl/carbamate, and having a degree of substitution of about 0.001 to about 3.0. The poly alpha-1,6-glucan comprises a backbone of glucose monomer units wherein greater than or equal to 40% of the glucose monomer units are linked via alpha-1,6 glycosidic linkages, and optionally at least 5% of the backbone glucose monomer units have branches via alpha-1,2 and/or alpha-1,3 glycosidic linkages. Compositions comprising a poly alpha-1,6-glucan derivative can be useful in various applications.

Abstract: A device may, in response to selection of a search area included in a webpage displayed within a display area of a browser: request a search for content of the search area, receive a searched query, a search result page for the searched query, and a related search request, and cause display of a first search request indicator and a second search request indicator within a search result area outside of the display area and within the browser. A device may receive a selection of the first search request indicator. A device may, in response to the selection of the first search request indicator, cause display of content for the first search request indicator within a navigation area of the search result area.

Abstract: A fingerprint detection method for a pharmaceutical preparation. The detection method uses an HPLC-DAD wavelength switching method to simultaneously determine a plurality of active ingredients such as mulberroside A, hydroxysafflor yellow pigment A, paeoniflorin, ferulic acid, calycosin-7-O-?-D-glucoside, rosmarinic acid, salvianolic acid B, formononetin, etc. in the pharmaceutical preparation. The sensitivity and accuracy of the detection method are greatly enhanced so as to ensure the comprehensive evaluation of the quality of the pharmaceutical preparation.