Patents by Inventor Gang Chen

Gang Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190307893
    Abstract: The application relates to liposomal nanovesicles comprising porphyrin-lipid conjugates within the liposomal lipid bilayer. Said porphyrin-lipid conjugate comprise porphyrins that are modified with a —CH(R1)—O—R2 group and that chelate a metal ion. Such modifications of the porphyrin allow for ordered assembly in the lipid bilayer of the nanovesicles while resulting in a bathochromic shift in the wavelength of light absorbed by the porphyrin chromophore. These nanovesicles can be used for photothermal therapy, photodynamic therapy, photoacoustic imaging and fluorescence imaging. The application also teaches methods for preparing the porphyrin-lipid conjugates and the nanovesicles.
    Type: Application
    Filed: March 10, 2017
    Publication date: October 10, 2019
    Inventors: Gang Zheng, Kenneth Ng, Juan Chen, Misa Takada, Kara Harmatys
  • Patent number: 10435461
    Abstract: The present invention addresses a need for improved treatments for filovirus infections. This invention provides an isolated humanized anti-filovirus glycoprotein pre-fusion core antibody comprising a framework region having a sequence of 95% or greater identity to a human antibody framework region. Also provided is a method of treating and/or inhibiting a filovirus infection in a subject comprising administering to the subject an amount of any of the antibodies described herein, or an amount of an antigen-binding fragment thereof. Also provided is composition comprising any of the antibodies described herein, or or an amount of an antigen-binding fragment thereof. In an embodiment, the composition comprises a pharmaceutically acceptably carrier.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: October 8, 2019
    Assignees: Albert Einstein College of Medicine, The Governing Council of the University of Toronto, The Government of the United States as Represented by the Secretary of the Army
    Inventors: Jonathan R. Lai, Jayne F. Koellhoffer, Julia Frei, Kartik Chandran, Sachdev Sidhu, Gang Chen, John M. Dye, Samantha Zak
  • Publication number: 20190298908
    Abstract: This invention is directed to a process for depleting one or more targeted substances such as toxins, proteins such as one or more immune checkpoint inhibitors (ICI), or a combination thereof from a subject. Immune checkpoint inhibitors (ICI), such as PD-1 protein, PD-1 ligand (PD-L1), CTLA-4, LAG-3, TIM3 and others are known to be involved in inhibition of T-cell activation in tumor patients. This invention is also directed to a device for depleting ICI such as PD-1 protein, PD-1 ligand (PD-L1) including soluble PD-L1 (sPD-L1), PD-L2, CTLA-4 including soluble form sCTLA-4, LAG-3, TIM3, or toxins from a subject. This invention is further directed to the use of the process and the devices for treating medical conditions such as cancers, other diseases and substance overdose.
    Type: Application
    Filed: June 11, 2019
    Publication date: October 3, 2019
    Inventors: Yan Chen, Gang G. Xu, Juanjuan Jiang, Juan Sheng
  • Publication number: 20190305555
    Abstract: Provided is a power grid adjustment method based on a load of a variable frequency air conditioner. The method includes: establishing a mathematical simulation model of a virtual synchronous motor in a variable frequency air conditioner controller; establishing a virtual inertia control segment and a droop control segment of power grid adjustment according to the mathematical simulation model; obtaining a reference value ?? of rotation speed variation of a compressor by the virtual inertia control segment; obtaining a reference value ?ref of rotational angular frequency of the compressor by the droop control segment; and inputting a sum of the reference value ?ref of rotational angular frequency of the compressor and the reference value ?? of rotation speed variation of the compressor into a field-oriented controller (FOC) to control rotation of a motor.
    Type: Application
    Filed: March 27, 2019
    Publication date: October 3, 2019
    Inventors: Jijun YIN, Gang CHEN, Xiao LU, Yaohong LI, Qifeng HUANG, Shufeng LU, Bin YANG, Feng YE, Haowei ZHANG, Xiao CHEN, Qiang ZHOU, Mingfeng XUE, Lingying HUANG, Shihai YANG, Qingshan XU, Minrui XU, Zhixin LI, Shuangshuang ZHAO, Feng WANG, Wenguang CHEN
  • Patent number: 10432036
    Abstract: A set of initialization parameters are generated for a wireless charging device. Parameters of an antenna circuit connected to an output of the control circuit are measured. The antenna circuit is modelled as first and second virtual antenna portions. The presence of a foreign object is detected by receiving, from a receiver device, characteristics for the antenna circuit and by measuring second parameters of the antenna circuit. The measured second parameters and the initialization parameters are used to determine characteristics for the first virtual antenna portion. A foreign object is detected based upon a comparison of the received characteristics for the antenna circuit and the determined characteristics for the first virtual antenna portion.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: October 1, 2019
    Assignee: NXP USA, Inc.
    Inventors: Gang Li, Fei Chen, Yuanhui Liu
  • Patent number: 10433037
    Abstract: A protective apparatus for sound-absorbing particles (4) in a sounding apparatus, comprising a housing (1) and a rear acoustic cavity formed inside the housing (1). The rear acoustic cavity is filled with sound-absorbing particles (4). A sound circulation channel (5) communicating the rear acoustic cavity with the outside is provided on the housing (1). A sound transmission layer (3) used for preventing the sound-absorbing particles (4) from being exposed covers an entrance of the sound circulation channel (5). The sound transmission layer (3) of the protective apparatus separates the sound circulation channel (5) from the rear acoustic cavity, such that airflow in the rear acoustic cavity passes through the sound transmission layer (3) and then flows out of the sound circulation channel (5).
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: October 1, 2019
    Assignee: Goertek Inc.
    Inventors: Zhenjun Li, Gang Chen, Yun Yang
  • Patent number: 10428135
    Abstract: A fusion polypeptide comprising (A)x-M-(A?)y, wherein A and A? are each polypeptides capable of binding a target receptor. The fusion polypeptides of the invention form multimeric proteins which activate the target receptor. A and A? may be each be an antibody or fragment derived from an antibody specific for a target receptor, such as the same or different scFv fragments, and/or a ligand or ligand fragment or derivative capable of binding the target protein, M is a multimerizing component, and X and Y are independently a number between 1-10.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: October 1, 2019
    Assignee: REGENERON PHARMACEUTICALS, INC.
    Inventors: James P. Fandl, Gang Chen, Nicholas J. Papadopoulos, Thomas H. Aldrich
  • Patent number: 10426814
    Abstract: Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-?), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and ?-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: October 1, 2019
    Assignee: The Penn State Research Foundation
    Inventors: Gong Chen, Gang-Yi Wu, Lei Zhang, Jiu-Chao Yin, Hana Yeh, Ning-Xin Ma, Grace Lee
  • Patent number: 10427345
    Abstract: Process for continuous fabrication of highly aligned polymer films. A polymer-solvent solution is subjected to a high shear, high temperature, Couette flow to extrude a thin film having polymer chain disentanglement. The extruded thin film is frozen and the solvent is allowed to evaporate to form a dried film. The dried film is mechanically drawn using a constant force, adaptive-thickness drawing system to align polymer molecular chains through plastic deformation. A suitable polymer is ultra-high molecular weight polyethylene.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: October 1, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Gang Chen, Jianjian Wang, Jonathan Kien-Kwok Tong, Hadi Ghasemi, Xiaopeng Huang, James Loomis, Yanfei Xu
  • Patent number: 10429681
    Abstract: The invention provides a structure of GOA circuit, which is manufactured on both sides of the ultra-thin flexible substrate with holes, wherein the wires pass through the holes to connect the TFTs in the GOA circuit on the front side to the TFTs in the GOA circuit on the back side to reduce the area occupied by GOA circuit. As such, the circuit area utilization is improved so that the same size of substrate area can carry almost twice the circuit structure to reduce the border width of the non-active area to achieve borderless or ultra-narrow border display panel with high resolution.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: October 1, 2019
    Assignee: SHENZHEN CHINA STAR OPTOELECTRONICS TECHNOLOGY CO., LTD.
    Inventors: Gang Wang, Lixuan Chen
  • Patent number: 10428073
    Abstract: Disclosed in the present invention are a salt type and crystal type of 4H-pyrazolo[1,5-alpha]benzimidazole compound and a preparation method and intermediate thereof.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: October 1, 2019
    Assignees: Hubei Bio-Pharmaceutical Industrial Technological Institute Inc., Humanwell Healthcare (Group) Co., Ltd.
    Inventors: Xuehai Wang, Charles Z. Ding, Jie Shen, Shuhui Chen, Lie Li, Gang Li, Yong Xu, Cailin Wang, Ronghua Tu, Jimeng Wang, Yang Yue, Biao Deng, Hailiang Chen, Hui Liu, Wenjie Sun, Cong Wang, Lu Huang, Zheng Wang, Weidong Li
  • Patent number: 10432091
    Abstract: A voltage regulator includes a first feedback circuit, a second feedback circuit, and a feedback signal adaptive circuit. The first voltage feedback circuit includes an amplifier that is configured to generate a compensation signal according to a feedback signal from an output of the voltage regulator and a reference voltage, while the second voltage feedback circuit includes a comparator that is configured to generate a PWM signal to drive a switch circuit in which the comparator initiates the PWM pulse when the feedback voltage goes lower than the compensation signal and ends the PWM pulse when the sum of the feedback signal and a ramp signal exceeds the sum of the compensation signal and a threshold signal. The feedback signal adaptive circuit modifies the feedback signal according to changes in an input voltage of the voltage regulator and a control signal.
    Type: Grant
    Filed: December 28, 2017
    Date of Patent: October 1, 2019
    Assignee: SEMICONDUCTOR COMPONENTS INDUSTRIES, LLC
    Inventor: Gang Chen
  • Publication number: 20190285932
    Abstract: The invention provides a structure of GOA circuit, which is manufactured on both sides of the ultra-thin flexible substrate with holes, wherein the wires pass through the holes to connect the TFTs in the GOA circuit on the front side to the TFTs in the GOA circuit on the back side to reduce the area occupied by GOA circuit. As such, the circuit area utilization is improved so that the same size of substrate area can carry almost twice the circuit structure to reduce the border width of the non-active area to achieve borderless or ultra-narrow border display panel with high resolution.
    Type: Application
    Filed: May 30, 2019
    Publication date: September 19, 2019
    Inventors: Gang Wang, Lixuan Chen
  • Publication number: 20190282969
    Abstract: A graphene oxide membrane with a controllable interlayer spacing, a preparation method and use thereof are provided. The preparation method provides of infiltrating a graphene oxide membrane in an aqueous solution A of salt to swell, thereby obtaining the graphene oxide membrane with the controllable interlayer spacing. The aqueous solution A of salt is a solution containing metal cation, and the concentration of the metal cation in the aqueous solution A is from 0.25-2.5 mol/L. The application can precisely control the size of the interlayer spacing of the graphene oxide membrane in the range of 11˜14 ?, and the variable range of this spacing can be controlled to within 0.6˜1 ?. The graphene oxide membrane with the controllable interlayer spacing of the application has excellent mechanical strength, which remains a complete membrane state after 5 hours of infiltration.
    Type: Application
    Filed: May 25, 2017
    Publication date: September 19, 2019
    Inventors: Haiping Fang, Minghong Wu, Guosheng Shi, Gang Xu, Liang Chen, Wanqin Jin, Jie Shen
  • Publication number: 20190284203
    Abstract: The present disclosure is directed to compounds of formula I? and methods of their use and preparation, as well as compositions comprising compounds of formula I?.
    Type: Application
    Filed: May 15, 2019
    Publication date: September 19, 2019
    Inventors: Nidhi Arora, Genesis M. Bacani, Joseph Kent Barbay, Scott D. Bembenek, Min Cai, Wei Chen, Charlotte Pooley Deckhut, James P. Edwards, Brahmananda Ghosh, Baoyu Hao, Kevin D. Kreutter, Gang Li, Mark S. Tichenor, Jennifer D. Venable, Jianmei Wei, John J.M. Wiener, Yao Wu, Yaoping Zhu, Feihuang Zhang, Zheng Zhang, Kun Xiao
  • Publication number: 20190284204
    Abstract: The present disclosure is directed to compounds of formula I? and methods of their use and preparation, as well as compositions comprising compounds of formula I?.
    Type: Application
    Filed: May 15, 2019
    Publication date: September 19, 2019
    Inventors: Nidhi Arora, Genesis M. Bacani, Joseph Kent Barbay, Scott D. Bembenek, Min Cai, Wei Chen, Charlotte Pooley Deckhut, James P. Edwards, Brahmananda Ghosh, Baoyu Hao, Kevin D. Kreutter, Gang Li, Mark S. Tichenor, Jennifer D. Venable, Jianmei Wei, John J.M. Wiener, Yao Wu, Yaoping Zhu, Feihuang Zhang, Zheng Zhang, Kun Xiao
  • Patent number: 10415055
    Abstract: Expression-enhancing nucleotide sequences for expression in eukaryotic systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells. Enhanced expression and stability regions (EESYRs) are provided for expression of a gene of interest in a eukaryotic cell. Chromosomal loci, sequences, and vectors are provided for enhanced and stable expression of genes in eukaryotic cells.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: September 17, 2019
    Assignee: REGENERON PHARMACEUTICALS, INC.
    Inventors: Gang Chen, Robert Babb, James P. Fandl
  • Patent number: 10417961
    Abstract: An organic light-emitting display panel, a driving method, and an organic light-emitting display device are provided. The organic light-emitting display panel comprises a plurality of pixel driving circuits, wherein a pixel driving circuit includes a first scan signal terminal and a second scan signal terminal; a light-emitting signal terminal, a data signal terminal, an initialization signal terminal, a first voltage terminal, and a second voltage terminal; a driving module comprising a driving transistor and a first capacitor having two electrode plates electrically connected to a gate electrode and a first electrode of the driving transistor, respectively; an initialization module comprising a first transistor, a first electrode, and a second electrode electrically connected to a second electrode of the driving transistor; a data writing module electrically connected to the gate electrode of the driving transistor; a light-emitting control module; and an organic light-emitting element.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: September 17, 2019
    Assignees: Shanghai Tianma AM-OLED Co., Ltd., Tianma Micro-Electronics Co., Ltd.
    Inventors: Dongxu Xiang, Yue Li, Tong Wu, Renyuan Zhu, Gang Liu, Dong Qian, Zeyuan Chen
  • Patent number: 10418408
    Abstract: An image sensor includes a plurality of photodiodes arranged in an array and disposed in a semiconductor material to receive light through a first surface of the semiconductor material. At least part of the semiconductor material is curved. A carrier wafer is attached to a second surface, opposite the first surface, of the semiconductor material, and a polymer layer is attached to the carrier wafer, so that the carrier wafer is disposed between the polymer layer and the semiconductor material.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: September 17, 2019
    Assignee: OmniVision Technologies, Inc.
    Inventors: Yuanwei Zheng, Chia-Chun Miao, Gang Chen, Yin Qian, Duli Mao, Dyson H. Tai, Lindsay Grant
  • Patent number: 10419992
    Abstract: Methods and apparatus to migrate a mobile device from a first virtual private mobile network to a second virtual private mobile network are disclosed. An example apparatus includes a processor and a memory including instructions that cause the processor to perform operations including determining, based on a set of latency routing rules, that a communication transmitted via the first virtual private mobile network is a latency sensitive communication. In response to determining the communication is a latency sensitive communication, the mobile device that originated the latency sensitive communication is identified. The mobile device is communicating via the first virtual private mobile network. Example operations also include migrating the mobile device from the first virtual private mobile network to the second virtual private mobile network wherein the second virtual private mobile network is configured to reduce the latency of the latency sensitive communication.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: September 17, 2019
    Assignee: AT&T Intellectual Property I, L.P.
    Inventors: Jacobus Van der Merwe, Xu Chen, Baris Coskun, Gustavo de los Reyes, Seungjoon Lee, Suhas Mathur, Arati Baliga, Gang Xu