Abstract: Disclosed is an oral drug delivery device, comprising a tubular member, a drug holding part, a device cap and a turbulence-creating means. The tubular member has openings at both ends and an inner cavity; the opening at one end is a first opening and the opening at the other end is a second opening; the inner cavity communicates the first opening and the second opening. The turbulence-creating means comprises a step structure or a fold structure, and is disposed in the inner cavity and positioned between the second opening and the drug holding part. By using the oral drug delivery device of the present invention, turbulence can be generated during a normal sipping process, thereby providing ample mixing of drug-containing granules or multi-particulates with drinkable liquids. Moreover, the device is telescopic, which reduces the size and is convenient to carry.

Abstract: A method for selecting parameters for tunnel support based on engineering-oriented behavior discrimination of surrounding rock includes: obtaining basic geological data of a running tunnel, establishing a model of a relative location relationship between the running tunnel and a stratum, and determining a chamber environment classification of a surrounding rock of the running tunnel; determining rock integrity of the surrounding rock of the running tunnel based on the basic geological data; determining a groundwater development level of the surrounding rock of the running tunnel based on the basic geological data; determining, based on the basic geological data, whether there is a slip surface on the surrounding rock of the running tunnel; and selecting support parameters for a corresponding support measure based on behavior of the surrounding rock including the chamber environment classification, the rock integrity, the groundwater development level, and whether the slip surface exists.

Abstract: A delaminated subway station structure in a sea-land connection region includes an openly-excavated station hall, a platform floor, a first air shaft duct, a second air shaft, up and down entrances and exits, a barrier-free entrance and exit, and an under-rail street passage, where the platform floor is formed by expanding an existing running tunnel, such that a double-vault structure of the platform floor is formed; two groups of up and down entrances and exits are disposed, and located in waiting regions on two sides respectively to connect expanded ear chambers on two sides and the openly-excavated station hall; two groups of barrier-free entrances and exits are disposed, and located in the waiting regions on the two sides respectively; and the under-rail street passage is closely attached to a bottom plate of the existing running tunnel to form an underpass and connects to the expanded ear chambers.

Abstract: A delaminated subway station structure in a sea-land connection region includes an openly-excavated station hall, a platform floor, a first air shaft duct, a second air shaft, up and down entrances and exits, a barrier-free entrance and exit, and an under-rail street passage, where the platform floor is formed by expanding an existing running tunnel, such that a double-vault structure of the platform floor is formed; two groups of up and down entrances and exits are disposed, and located in waiting regions on two sides respectively to connect expanded ear chambers on two sides and the openly-excavated station hall; two groups of barrier-free entrances and exits are disposed, and located in the waiting regions on the two sides respectively; and the under-rail street passage is closely attached to a bottom plate of the existing running tunnel to form an underpass and connects to the expanded ear chambers.

Abstract: A cyclic peptide, and a preparation method and use thereof. The cyclic peptide is a series of head-to-tail cyclic peptides or N-terminal and C-terminal cyclized peptides with triazole rings, which are prepared by an azido-alkyne cycloaddition reaction of the whole sequence of linear histamine or the truncated sequence of a linear Hst1 under specific conditions. The biological activity of the full-sequence head-to-tail cyclic peptide or N-terminal and C-terminal cyclized peptide is increased by more than 1,000 times compared with that of the linear histamine, can significantly improve a dose-effect ratio and clinical efficacy of the histamine over the existing histamine cyclic peptide.

Abstract: A section of a node of the station is a section with an arch roof and a straight wall of three underground floors, a first underground floor is a station hall floor 1, and a second underground floor is a platform floor 2 of a subway line A and a third underground floor is a platform floor 3 of a subway line B; and directions of the subway line A and the subway line B are orthogonal. Second lining structures of the first and second underground floors are firstly constructed, and after a shield tunneling machine is pushed through the station, the structure of the third underground floor is constructed by a reverse construction method. Thus, the present disclosure is conducive to improving the efficiency of overall construction, guaranteeing timely tunnel construction completion of two lines and hence timely track construction completion and electricity wiring completion.

Abstract: The disclosure provides a display apparatus, and the display apparatus at least includes a display and a controller. At an initial state, the display presents a homepage; in response to a startup instruction, the display jumps to a search interface from the homepage; the search interface has a user interface, and the user interface is configured to receive a search content input from a user; in response to a search instruction, the controller reads the search content; and if the search content includes a phrase for locating, the controller controls an application corresponding to the phrase for locating to be started so as to transmit the search content to the application to cause the application to send a request carrying the search content to a server of the application.

Abstract: The present application provides an inhibitory compound, such as a peptide, and methods for using the inhibitory compound in the treatment, diagnosis or monitoring of cognitive and mood disorders that are typically associated with memory loss and/or loss of executive function. In one example, the inhibitory compound is a peptide that mimics the N-terminal sequence of the intracellular loop of ?5 subunit of ?5GABAA receptors. Also provided are compositions and methods for treating a disorder associated with memory loss or loss of executive function. The therapeutic method comprises the step of inhibiting binding of radixin to ?5GABAA receptors, for example, by administration of the presently described inhibitory compound or peptide.

Abstract: Combination of an open and a hidden excavation for constructing a vertical orthogonal top exhausting air duct structure of a deeply-buried subway station is provided. Four horizontal air ducts: left and right piston air ducts, an exhaust air duct, and a fresh air duct are thrown out of the underground, respectively, leading to left and right piston air shafts, an exhaust air shaft, a fresh air shaft, and an entrance/exit of fire-fighting. The fourth underground floor is communicated with the hall floor of the station main body, and the fifth underground floor is communicated with the running tunnel and the platform floor of the station main body. During operation, the train will enter and exit the station through the fifth underground floor of the air duct, and the piston air and heat will enter the four transverse air ducts through the air duct main body.

Abstract: A method for constructing a large-span station by two-wing open type semi-covered excavation and semi-reverse construction, is divided into three stages of excavation. First, excavate a first-stage inner small foundation pit, then excavate a second-stage annular foundation pit within the first-stage retaining piles and outside the range of the first-stage inner small foundation pit, and finally excavate a third-stage semi-covered excavation foundation pit below the first-stage inner small foundation pit and the second-stage annular foundation pit. By setting graded retaining piles, middle upright post piles, middle top plates, local waist beams and local concrete supports in the soil-rock combination strata, so that the force transfer between the foundation pit enclosure and the station main body structures and the underlying rock layer is clear and reliable, and a stable frame structure is achieved.

Abstract: A method for constructing a large-span station by two-wing open type semi-covered excavation and semi-reverse construction, is divided into three stages of excavation. First, excavate a first-stage inner small foundation pit, then excavate a second-stage annular foundation pit within the first-stage retaining piles and outside the range of the first-stage inner small foundation pit, and finally excavate a third-stage semi-covered excavation foundation pit below the first-stage inner small foundation pit and the second-stage annular foundation pit. By setting graded retaining piles, middle upright post piles, middle top plates, local waist beams and local concrete supports in the soil-rock combination strata, so that the force transfer between the foundation pit enclosure and the station main body structures and the underlying rock layer is clear and reliable, and a stable frame structure is achieved.

Abstract: Combination of an open and a hidden excavation for constructing a vertical orthogonal top exhausting air duct structure of a deeply-buried subway station is provided. Four horizontal air ducts: left and right piston air ducts, an exhaust air duct, and a fresh air duct are thrown out of the underground, respectively, leading to left and right piston air shafts, an exhaust air shaft, a fresh air shaft, and an entrance/exit of fire-fighting. The fourth underground floor is communicated with the hall floor of the station main body, and the fifth underground floor is communicated with the running tunnel and the platform floor of the station main body. During operation, the train will enter and exit the station through the fifth underground floor of the air duct, and the piston air and heat will enter the four transverse air ducts through the air duct main body.

Abstract: Provided are a refreshing method and a display apparatus. The method includes: presenting a video on a display of the display apparatus; detecting whether a content type of the video is switched from a first content type to a second content type; obtaining first picture quality parameter information matching the second content type from preset data of the display apparatus, wherein the preset data includes a predefined relation between a content type and picture quality parameter information, updating the parameter of the at least one picture quality setting option in the picture mode settings menu according to the first picture quality parameter information, and presenting the second section of the video according to the updated parameter of the at least one picture quality setting option in the picture mode settings menu.

Abstract: The disclosure provides a display apparatus, and the display apparatus at least includes a display and a controller. At an initial state, the display presents a homepage; in response to a startup instruction, the display jumps to a search interface from the homepage; the search interface has a user interface, and the user interface is configured to receive a search content input from a user; in response to a search instruction, the controller reads the search content; and if the search content includes a phrase for locating, the controller controls an application corresponding to the phrase for locating to be started so as to transmit the search content to the application to cause the application to send a request carrying the search content to a server of the application.

Abstract: A login method and system based on a cloud application instance, and a related device are provided. The method includes the following steps: A cloud application instance sends a login request for an application service node to a terminal device, such that after obtaining a login password input by a user, the terminal device sends a verification request carrying the login password and a device identity of the cloud application instance to an account management node. The account management node may verify the login password, and send verification success information to the cloud application instance. The cloud application instance logs in to the application service node based on the verification success information using.

Abstract: The present invention provides a low-energy coastal beach restoration method, comprising: constructing a convex beach berm, determining an aspect ratio of the beach berm edge, determining a beach face slope, performing sand replenishment, determining the dredging zone and dredging depth, and determining the steps of building a sediment groin. The present invention utilizes the feature of the convergence effect of the wave energy on the headland, artificially constructs a convex headland shaped beach berm, and determines the required beach face range and slope according to the convex beach berm edge. During beach restoration, dredging around the beach face, while reducing mud sources and increasing the nearshore water depth, it also builds a convex nearshore terrain, which effectively increases the wave energy at the restoration site and improves the coast muddy situation of low-energy coasts.

Abstract: The present invention provides a low-energy coastal beach restoration method, comprising: constructing a convex beach berm, determining an aspect ratio of the beach berm edge, determining a beach face slope, performing sand replenishment, determining the dredging zone and dredging depth, and determining the steps of building a sediment groin. The present invention utilizes the feature of the convergence effect of the wave energy on the headland, artificially constructs a convex headland shaped beach berm, and determines the required beach face range and slope according to the convex beach berm edge. During beach restoration, dredging around the beach face, while reducing mud sources and increasing the nearshore water depth, it also builds a convex nearshore terrain, which effectively increases the wave energy at the restoration site and improves the coast muddy situation of low-energy coasts.

Abstract: The present application provides an inhibitory compound, such as a peptide, and methods for using the inhibitory compound in the treatment, diagnosis or monitoring of cognitive and mood disorders that are typically associated with memory loss and/or loss of executive function. In one example, the inhibitory compound is a peptide that mimics the N-terminal sequence of the intracellular loop of ?5 subunit of ?5GABAA receptors. Also provided are compositions and methods for treating a disorder associated with memory loss or loss of executive function. The therapeutic method comprises the step of inhibiting binding of radixin to ?5GABAA receptors, for example, by administration of the presently described inhibitory compound or peptide.

Abstract: The present application provides an inhibitory compound, such as a peptide, and methods for using the inhibitory compound in the treatment, diagnosis or monitoring of cognitive and mood disorders that are typically associated with memory loss and/or loss of executive function. In one example, the inhibitory compound is a peptide that mimics the N-terminal sequence of the intracellular loop of ?5 subunit of ?5GABAA receptors. Also provided are compositions and methods for treating a disorder associated with memory loss or loss of executive function. The therapeutic method comprises the step of inhibiting binding of radixin to ?5GABAA receptors, for example, by administration of the presently described inhibitory compound or peptide.

Abstract: Provided are a quality control method for banknote identification and a quality control system for banknote identification. The quality control method for banknote identification includes: obtaining a multispectral signal collected by a contact image sensor (CIS); extracting a first eigenvalue of the multispectral signal; obtaining a corresponding second eigenvalue according to the first eigenvalue and a pre-set correction conversion value; and inputting the second eigenvalue into a banknote classifier to obtain a corresponding banknote classification result.