Abstract: Disclosed are a polyethylene glycol conjugate drug, and a preparation method therefor and the use thereof. Specifically, the present invention relates to a polyethylene glycol conjugate drug represented by formula A or a pharmaceutically acceptable salt thereof, a method for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, an intermediate for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, and the use of the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof in the preparation of a drug.

Abstract: A brake system that includes a brake caliper comprising an inboard side and an outboard side, the inboard side of the brake caliper includes one or more brake pistons and the outboard side of the brake caliper comprises one or more brake pistons, and a brake pad comprising a first pad section and a second pad section. During a service brake apply, both of the first pad section and the second pad section are moved against a braking surface to create a clamping force. During a parking brake apply, only one of the first pad section and the second pad section is moved against the braking surface to create a clamping force. The first pad section comprises a friction material having a coefficient of friction that is different than a coefficient of friction of the second pad section.

Abstract: A method of determining the cumulative damage of a brake system, the method comprising: (a) estimating or measuring one or more brake forces based upon one or more parameters; (b) determining a cycle for each of the brake forces and associating each brake force with the determined cycle; and (c) determining a cumulative damage of the brake system based upon the determined cycles and the associated brake forces.

Abstract: A brake system that includes a brake caliper comprising an inboard side and an outboard side, the inboard side of the brake caliper includes one or more brake pistons and the outboard side of the brake caliper comprises one or more brake pistons, and a brake pad comprising a first pad section and a second pad section. During a service brake apply, both of the first pad section and the second pad section are moved against a braking surface to create a clamping force. During a parking brake apply, only one of the first pad section and the second pad section is moved against the braking surface to create a clamping force. The first pad section comprises a friction material having a coefficient of friction that is different than a coefficient of friction of the second pad section.

Abstract: A brake assembly, a brake system, and a method of applying a brake. The brake assembly includes a fixed caliper system and a sliding caliper system. Both of the fixed caliper system and the sliding caliper system operate together during a brake operation to generate a clamping force. The common brake operation may be a service brake operation, a parking brake operation, or both.

Abstract: A disc brake system that is an opposed piston brake system. The disc brake system includes a brake caliper having an inboard side and an outboard side. The inboard side of the brake caliper is configured to support more brake pistons than the outboard side of the brake caliper.

Abstract: A floating caliper brake assembly comprising: a caliper housing that is movable between a brake on position and a brake off position; a support bracket at least partially enclosed by the caliper housing and configured to extend around a rotor of a vehicle, the caliper housing being in communication with and movable relative to the support bracket, wherein the caliper housing has one or more fingers that extend radially downward and cover the support bracket so that when the brake assembly is viewed from an outboard side along an axis coaxial with, or substantially parallel to, an axis of rotation of the rotor the support bracket is obscured from view.

Abstract: A floating caliper brake assembly comprising: a caliper housing that is movable between a brake on position and a brake off position; a support bracket at least partially enclosed by the caliper housing and configured to extend around a rotor of a vehicle, the caliper housing being in communication with and movable relative to the support bracket, wherein the caliper housing has one or more fingers that extend radially downward and cover the support bracket so that when the brake assembly is viewed from an outboard side along an axis coaxial with, or substantially parallel to, an axis of rotation of the rotor the support bracket is obscured from view.

Abstract: A brake system that includes a first brake piston; a second brake piston; a first rotary to linear mechanism disposed inside of the first brake piston; a second rotary to linear mechanism disposed inside of the second brake piston; and a motor. The motor is configured to generate torque and supply the generated torque generally equally to both of the first and the second rotary to linear mechanism during a brake apply. A compressible member may be provided between a first member and the first brake piston, a second member and the second brake piston, or both.

Abstract: A disc brake system that is an opposed piston brake system. The disc brake system includes a brake caliper having an inboard side and an outboard side. The inboard side of the brake caliper is configured to support more brake pistons than the outboard side of the brake caliper.

Abstract: A brake system comprising: (a) a rotor; and (b) two or more brake assemblies in communication with the rotor, the two or more brake assemblies each including: (i) a caliper; (ii) a piston assembly located within the caliper; and (iii) a motor gear unit in communication with the caliper and configured to move the piston assembly to create a braking force; wherein one or more both of the piston assemblies are moved during a service brake apply or release; and wherein one or both of the piston assemblies are moved during a parking brake apply or release.

Abstract: A brake system comprising: (a) a rotor; and (b) two or more brake assemblies in communication with the rotor, the two or more brake assemblies each including: (i) a caliper; (ii) a piston assembly located within the caliper; and (iii) a motor gear unit in communication with the caliper and configured to move the piston assembly to create a braking force; wherein one or more both of the piston assemblies are moved during a service brake apply or release; and wherein one or both of the piston assemblies are moved during a parking brake apply or release.

Abstract: A pad clip comprising two or more discrete pieces comprising: one or more clip body sections including a bridge attachment segment located at a bridge end, a spring attachment segment located at a spring end, or both; and one or more bridge sections, one or more retraction springs, or both; wherein the two or more discrete pieces are adapted to be attached together at the bridge attachment segment, spring attachment segment, or both. The teachings also include a method of forming the pad clip, comprising: forming two or more clip body sections, each clip body section including a spring attachment segment; forming one or more retraction springs; attaching the one or more retraction springs to the spring attachment segment of the two or more clip body sections; and installing the pad clip about a support bracket of a brake assembly.

Abstract: A pad clip comprising two or more discrete pieces comprising: one or more clip body sections including a bridge attachment segment located at a bridge end, a spring attachment segment located at a spring end, or both; and one or more bridge sections, one or more retraction springs, or both; wherein the two or more discrete pieces are adapted to be attached together at the bridge attachment segment, spring attachment segment, or both. The teachings also include a method of forming the pad clip, comprising: forming two or more clip body sections, each clip body section including a spring attachment segment; forming one or more retraction springs; attaching the one or more retraction springs to the spring attachment segment of the two or more clip body sections; and installing the pad clip about a support bracket of a brake assembly.

Abstract: A pad clip comprising: two opposing legs separated by a gap, the two opposing legs comprising: (i) a projection arm including: (A) an upper portion, (B) a lower portion, and (C) a face portion connecting the upper portion and the lower portion together; (ii) a connection arm; and (iii) an abutment arm extending between and connecting the projection arm and the connection arm; wherein the lower portion of the projection arm, the connection arm, or both include an arcuate segment that extends the lower portion, the connection arm, or both towards each other so that when the pad clip is installed in a support bracket a space is formed between the arcuate segment and the support bracket.

Abstract: A brake pad comprising: (a) friction material and (b) a pressure plate comprising: (i) an ear on a trailing side and (ii) an ear on a leading side; wherein the ear on the trailing side and the ear on the leading side are configured for placement in a trailing abutment and a leading abutment of a support bracket respectively so that during a brake apply the ear on the trailing side is moved into contact with the abutment on the trailing side or the ear on the leading side is moved into contact with the abutment on the leading side: and wherein the ear on the trailing side, the ear on the leading side, or both include an arcuate segment forming a concave recess that has a continuous curvature.

Abstract: A pad clip comprising: two opposing legs separated by a gap, the two opposing legs comprising: (i) a projection arm including: (A) an upper portion, (B) a lower portion, and (C) a face portion connecting the upper portion and the lower portion together; (ii) a connection arm; and (iii) an abutment arm extending between and connecting the projection arm and the connection arm; wherein the lower portion of the projection arm, the connection arm, or both include an arcuate segment that extends the lower portion, the connection arm, or both towards each other so that when the pad clip is installed in a support bracket a space is formed between the arcuate segment and the support bracket.

Abstract: A full contact brake comprising: (a) an inboard housing including: an inner and outer seal groove including a seal; (b) an outboard housing including: an inner and outer seal groove including a seal; and (c) a bridge tube between the inboard housing and the outboard housing; wherein the inboard housing, the outboard housing, and the bridge tube form a housing comprising: (i) an inboard piston between the inner and outer seal groove; (ii) an outboard piston between the inner and outer seal groove; and (iii) a rotor between the inboard and outboard piston so that the inboard piston is moved towards an inboard side and the outboard piston is moved towards an outboard side of the rotor; and wherein the seal of the inboard housing forms an interference fit around the respective piston so that rotation of the inboard and outboard piston respectively are substantially prevented during a brake apply.

Abstract: A full contact brake comprising: (a) an inboard housing including: an inner and outer seal groove including a seal; (b) an outboard housing including: an inner and outer seal groove including a seal; and (c) a bridge tube between the inboard housing and the outboard housing; wherein the inboard housing, the outboard housing, and the bridge tube form a housing comprising: (i) an inboard piston between the inner and outer seal groove; (ii) an outboard piston between the inner and outer seal groove; and (iii) a rotor between the inboard and outboard piston so that the inboard piston is moved towards an inboard side and the outboard piston is moved towards an outboard side of the rotor; and wherein the seal of the inboard housing forms an interference fit around the respective piston so that rotation of the inboard and outboard piston respectively are substantially prevented during a brake apply.

Abstract: A seal groove comprising: a back wall; a front wall opposed to the back wall; a bottom wall connected to the front wall and the back wall; and a recess in the front wall connecting the front wall to the piston bore; wherein the recess includes a peak which comprises: a first angled portion and a second angled portion.