Abstract: The present application disclosed a method for automatically predicting treatment management factor characteristics and an electronic apparatus, the method includes: acquiring, by the electronic apparatus, concerted effect burden parameter data of several mutant genes of a tested sample of a target object on expression activity of each gene in a predetermined genome, wherein the predetermined genome corresponds to the disease; and outputting, by the electronic apparatus, predictive data of at least one treatment management factor characteristic of the target object relative to the disease based on the concerted effect burden parameter data.

Abstract: A method for obtaining an intracellular deterministic event, and an electronic device. The method includes: an electronic device obtaining several pieces of mutant gene information of a tested sample extracted from a target object; and the electronic device obtaining, according to the several pieces of mutant gene information, comprehensive influence parameter data of several mutant genes regarding the expression activity of each gene in a predetermined genome.

Abstract: A disease type automatic determination method and an electronic device, wherein the method includes: the electronic device obtains comprehensive influence parameter data of several mutant genes of a tested sample on expression activity of each gene in a predetermined genome (S81); and the electronic device determines a disease type label corresponding to the tested sample on the basis of the comprehensive influence parameter data of the several mutant genes of the tested sample on expression activity of each gene in the predetermined genome.

Abstract: The present application discloses a method for acquiring intracellular deterministic event, an electronic device and a storage medium, the method includes: acquiring several mutant genes of a detected object; acquiring driving force information of each of the several mutant genes for changes of each gene in a predetermined genome; acquiring driving force information of the several mutant genes for changes of each gene in the predetermined genome according to the acquiring driving force information of each of the several mutant genes for changes of each gene in the predetermined genome; and determining at least onepredetermined type of intracellular deterministic event information of the detected object according to the driving force information of the several mutant genes for changes of each gene in the predetermined genome.

Abstract: A method for predicting a risk of suffering from a disease, includes: acquiring driving force information of mutant genes belonging to a pre-determined genome of a detected object for changes in activity of a plurality of pre-determined signaling pathways; acquiring driving force information of mutant genes belonging to a pre-determined genome of each reference object in first and second reference object groups for the changes in the activity of the plurality of pre-determined signaling pathways; where each reference object in the first reference object group belongs to a healthy object, and each reference object in the second reference object group belongs to an object suffering from a specific disease; performing a first clustering on the detected object, and each reference object in the first and second reference object groups; and outputting a risk of the detected object suffering from the specific disease.

Abstract: A compound of Formula (I) or a pharmaceutically acceptable ester, amide, solvate, or salt thereof, or a salt of such an ester or amide or a solvate of such an ester amide or salt, is disclosed. Compositions comprising the compound and methods of use are also disclosed. Those dimeric Evans Blue derivatives, denoted as N(tEB)2, reversibly bind two molecules of albumin via the two albumin binding regions of each NtEB in the dimer, resulting in significantly increased binding affinity to albumin and extended circulation half-life in vivo. Further, when the N(tEB)2 is conjugated to a peptide therapeutic, the in situ formation of the complex of N(tEB)2 with two albumin molecules resulted in increased resistance of the peptide therapeutic from proteolysis.

Abstract: The present invention is directed to a compound of Formula I or Formula II or a pharmaceutically acceptable ester, amide, solvate, or salt thereof, or a salt of such an ester or amide or a solvate of such an ester amide or salt: Formula I Formula II The compounds of Formula I may be covalently bonded to a therapeutic compound or fragment thereof to provide a compound of Formula II and thereby extend the half-life of the therapeutic compound. The invention is also directed to pharmaceutical compositions of the disclosed compounds, as well as their use in the diagnosis or treatment of diseases.

Abstract: The present invention is directed to a compound of Formula I or Formula II or a pharmaceutically acceptable ester, amide, solvate, or salt thereof, or a salt of such an ester or amide or a solvate of such an ester amide or salt: Formula I Formula II The compounds of Formula I may be covalently bonded to a therapeutic compound or fragment thereof to provide a compound of Formula II and thereby extend the half-life of the therapeutic compound. The invention is also directed to pharmaceutical compositions of the disclosed compounds, as well as their use in the diagnosis or treatment of diseases.

Abstract: Disclosed is a compound of formula (I): wherein L, R1-R5, A, B, M, and n are as defined in the specification, as well as a method of preparing the compound. Also disclosed are a method of blood-pool imaging in a mammal and a method of imaging a lymph node in a mammal, comprising use of the compound.

Abstract: The present invention provides a construction method of cell models for detecting pyrogens, cell models and pyrogen detection kits. By inducing double-bond breakage in the specific positions of genomes using CRISPR/CAS9, performing directed knock-in of TLR4 and CD14-MD2 on two chromosomes in a cell line based on the principle of homologous recombination and repair, and tracing using green fluorescent protein GFP and red fluorescent protein RFP respectively, we successfully construct the TLR4/CD14/MD2 directed knock-in and fluorescence-traceable cell model; upon the exposure to LPS, the release of IL-6 and TNF-a cytokines in the cell model can be detected by ELISA, Western Blot, mass spectrometry and magnetic bead method; and the cell model has good stability and high sensitivity, and the lowest detection limit can reach 0.005 EU/mL, which is far lower than that of the Limulus amebocyte lysate endotoxin test method (0.025 EU/mL).

Abstract: A reliability management system and its operation method is presented. The reliability management system comprises instructions stored in a computer-readable non-transitory storage medium, with said instructions executable by one or more hardware processors communicating with the storage medium, the system comprises a reliability manager and a Reliability Test Requestor (RTR). The reliability manager receives a test equipment request from the RTR and sends corresponding test equipment information to the RTR. The RTR sends a test equipment request to the reliability manager based on product information of a test product it receives, and receives test data from a corresponding test equipment according to the test equipment information received from the reliability manager. The RTR also processes the test data to generate a test report, and determines whether the test product passed a reliability test based on the test report. This inventive concept realizes an automatic management on reliability tests.

Abstract: Disclosed is a compound of formula (I): wherein L, R1-R5, A, B, M, and n are as defined in the specification, as well as a method of preparing the compound. Also disclosed are a method of blood-pool imaging in a mammal and a method of imaging a lymph node in a mammal, comprising use of the compound.

Abstract: A full-automatic microorganism detecting enrichment system and the enrichment method thereof are provided. A transmission apparatus is controlled by a industrial control computer to transmit a to-be-detected sample placed on a preset operating position, a culture medium comprising culture, a pipeline filter specially for collecting bacteria and a filter head sequentially into a sterilization cabin, an middle package removing cabin, an inner package removing cabin, an enrichment operating cabin, a buffer cabin and a positive bacteria filling cabin to perform corresponding operations and enrich the microorganism in the to-be-detected samples. Said system can achieve a fully automated enrichment of the microorganism in the to-be-detected samples, needs no manual operation, and saves time and labor force. Further, it can avoid false positive or false negative result caused by an effect of human factor, and achieve sterile and automatic operation with an accurate detection result.

Abstract: Disclosed is a compound of formula (I): wherein L, R1-R5, A, B, M, and n are as defined in the specification, as well as a method of preparing the compound. Also disclosed are a method of blood-pool imaging in a mammal and a method of imaging a lymph node in a mammal, comprising use of the compound.

Abstract: The disclosure provides a device for preventing CSRF attacks, in which the device provides functions comprising: intercepting request sent from a client browser to a server; generating a token; generating a response to the request; inserting the token into the response to the request; and sending the response to the request to the client browser with the token inserted into the response. With the device of the disclosure, it is assured that a token is inserted into all the requests made by a user through a client browser for accessing a resource. And it can be assured that the request is issued by the user himself by verifying whether the token in the request is valid, thereby preventing a CSRF attack.

Abstract: The disclosure provides method for preventing CSRF attacks, in which the method provides: intercepting request sent from a client browser to a server; generating a token; generating a response to the request; inserting the token into the response to the request; and sending the response to the request to the client browser with the token inserted into the response. With the method of the disclosure, it is assured that a token is inserted into all the requests made by a user through a client browser for accessing a resource. And it can be assured that the request is issued by the user himself by verifying whether the token in the request is valid, thereby preventing a CSRF attack.

Abstract: The disclosure provides method for preventing CSRF attacks, in which the method provides: intercepting request sent from a client browser to a server; generating a token; generating a response to the request; inserting the token into the response to the request; and sending the response to the request to the client browser with the token inserted into the response. With the method of the disclosure, it is assured that a token is inserted into all the requests made by a user through a client browser for accessing a resource. And it can be assured that the request is issued by the user himself by verifying whether the token in the request is valid, thereby preventing a CSRF attack.

Abstract: A passively mode-locked picosecond laser device comprising a pump source, a laser crystal, a laser cavity, a mode-locked output structure is provided. In the device, the pump source is placed at the side of the incident end surface of the laser crystal; the laser cavity includes a plane reflective mirror and a first plano-concave mirror, the reflective mirror is placed opposite to the concave surface of the plano-concave mirror and located on the position of the focal radius of the plano-concave mirror. The normal direction of the reflective mirror and the axis of the plano-concave mirror form a small angle therebetween; the laser generated from the laser crystal oscillates in the laser cavity, and output through the mode-locked output structure. The device uses a stable cavity design of the equivalent confocal cavity, which can increase the optical path, reduce the repetition frequency, and significantly reduce the cavity length and volume.

Abstract: The disclosure provides a device and method for preventing CSRF attacks, in which the method comprises: intercepting request sent from a client browser to a server; generating a token; generating a response to the request; inserting the token into the response to the request; and sending the response to the request to the client browser with the token inserted into the response. With the method and device of the disclosure, it is assured that a token is inserted into all the requests made by a user through a client browser for accessing a resource. And it can be assured that the request is issued by the user himself by verifying whether the token in the request is valid, thereby preventing a CSRF attack.