Abstract: The present disclosure relates to the technical field of pyridine acetamide derivatives, and specifically relates to a pyridine acetamide derivative as a CDK inhibitor, a preparation method therefor and a use thereof. The pyridine acetamide derivative exhibits excellent CDK9/CDK7 kinase inhibitory activity, and can be used for preparing medications for treating cancers; and the cancers are particularly blood cancers, including acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, follicular lymphoma and the like, and solid tumors, including breast cancer, prostate cancer, ovarian cancer, hepatocellular carcinoma, pancreatic cancer, kidney cancer, stomach cancer, colorectal cancer, lung cancer and the like.

Abstract: The present disclosure belongs to the technical field of polycyclic amide derivatives, in particular to a polycyclic amide derivative as a CDK9 inhibitor, a preparation method therefor and use thereof. The polycyclic amide derivative exhibits an excellent CDK9 kinase inhibitory activity, and can be used for preparing a medicine for treating cancers, wherein the cancers are especially hematological cancers, including acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, follicular lymphoma and solid tumors including breast cancer, prostate cancer, ovarian cancer, hepatocellular cancer, pancreatic cancer, renal cancer, gastric cancer, colorectal cancer, lung cancer, and the like.

Abstract: A method for recognizing an abnormal sleep audio clip, includes: obtaining a plurality of initial audio clips collected by a sensor, and determining a target audio clip matching a preset sleep state from the initial audio clips; determining first snore information before the target audio clip and second snore information after the target audio clip based on the initial audio clips; determining a confidence value for the target audio clip based on the first snore information and the second snore information; and determining whether the target audio clip is the abnormal sleep audio clip based on the confidence value of the target audio clip.

Abstract: A method and an apparatus for presenting a candidate character string and a method and an apparatus for training a discriminative model are provided. The method for presenting a candidate character string may include: acquiring a character string of alphabetic words inputted by a user; determining a character transition weight of the character string, the character transition weight being used to characterize a transition probability of a character; generating a sort weight corresponding to the character string based on a pre-acquired basic weight matching the character string and the character transition weight; and selecting, according to an order indicated by the sort weight, at least two candidate character strings matching the character string from a pre-acquired candidate character string set for presentation.

Abstract: The present invention relates to a bromodomain inhibitor. Provided are a compound represented by general formula I or a pharmaceutically acceptable salt, enantiomer, diastereomer, atropisomer, racemate, polymorph, solvate, or isotopically labeled compound (including deuterium substitution) thereof, a preparation method of the same, a pharmaceutical composition comprising the same, and a pharmaceutical use thereof.

Abstract: A method for generating a user interest profile includes: generating at least one keyword by extracting information from input information of a user; generating interest tags corresponding to the at least one keyword by matching the at least one keyword with tags corresponding to nodes of a knowledge graph; sorting the interest tags corresponding to the at least one keyword; and generating a user interest profile based on the sorted interest tags corresponding to the at least one keyword.

Abstract: An input method for a virtual keyboard includes: in response to acquiring a click operation on the virtual keyboard, determining a click position of the click operation; determining a first probability that the click operation belongs to each key based on the click position and a current response region corresponding to each key in the virtual keyboard; determining a second probability that the click operation belongs to each key based on an input character sequence; and determining a target key corresponding to the click operation based on the first probability and the second probability for each key.

Abstract: Disclosed is a histone acetyltransferase (HAT) inhibitor. Provided are a compound represented by the general formula I, a pharmaceutically acceptable salt, a stereoisomer, an enantiomer, a diastereoisomer, an atropisomer, a racemate, a polymorph, a solvate or an isotope-labeled compound (including deuterium substitution) thereof, a preparation method therefor, a pharmaceutical composition comprising same and use thereof in the treatment of various HAT-related diseases or conditions.

Abstract: An input method for a virtual keyboard includes: in response to acquiring a click operation on the virtual keyboard, determining a click position of the click operation; determining a first probability that the click operation belongs to each key based on the click position and a current response region corresponding to each key in the virtual keyboard; determining a second probability that the click operation belongs to each key based on an input character sequence; and determining a target key corresponding to the click operation based on the first probability and the second probability for each key.

Abstract: The present invention provides a compound represented by formula I, pharmaceutically acceptable salts, enantiomers, diastereomers or racemates thereof, the preparation method thereof, the pharmaceutical composition comprising the same, and the use thereof in the preparation of a medicament for treating a disease or condition mediated by EED and/or PRC2. The compound of the present invention can be used treating PRC2-mediated diseases or conditions.

Abstract: Disclosed is a histone acetyltransferase (HAT) inhibitor. Provided are a compound represented by the general formula I, a pharmaceutically acceptable salt, a stereoisomer, an enantiomer, a diastereoisomer, an atropisomer, a racemate, a polymorph, a solvate or an isotope-labeled compound (including deuterium substitution) thereof, a preparation method therefor, a pharmaceutical composition comprising same and use thereof in the treatment of various HAT-related diseases or conditions.

Abstract: The application provides a character correction method and apparatus, a device, and a storage medium, where the method including: obtaining position information of a click operation of a user on a terminal screen, and obtaining feature information of the click operation; determining distance information between the position information and each key on the terminal screen; determining transition probability information from a character indicated by a history click operation to a character corresponding to each key; determining a character prediction result according to the feature information, the distance information and the transition probability information, where the character prediction result comprises a probability score that the character indicated by the click operation belongs to the character corresponding to each key; and determining the character with a highest probability score as a correction character corresponding to the click operation.

Abstract: The present invention relates to a bromodomain inhibitor. Provided are a compound represented by general formula I or a pharmaceutically acceptable salt, enantiomer, diastereomer, atropisomer, racemate, polymorph, solvate, or isotopically labeled compound (including deuterium substitution) thereof, a preparation method of the same, a pharmaceutical composition comprising the same, and a pharmaceutical use thereof.

Abstract: A method and system for locating a sound source are provide. The method may include detecting a sound signal of a sound by each of two audio sensors. The method may also include converting the sound signals detected by the two audio sensors from a time domain to a frequency domain. The method may further include determining a high frequency ratio of each of the sound signals in the frequency domain. The method may further include determining a direction of the sound source based on the high frequency ratios.

Abstract: The present invention provides a compound represented by formula I, pharmaceutically acceptable salts, enantiomers, diastereomers or racemates thereof, the preparation method thereof, the pharmaceutical composition comprising the same, and the use thereof in the preparation of a medicament for treating a disease or condition mediated by EED and/or PRC2. The compound of the present invention can be used treating PRC2-mediated diseases or conditions.

Abstract: The application provides a character correction method and apparatus, a device, and a storage medium, where the method including: obtaining position information of a click operation of a user on a terminal screen, and obtaining feature information of the click operation; determining distance information between the position information and each key on the terminal screen; determining transition probability information from a character indicated by a history click operation to a character corresponding to each key; determining a character prediction result according to the feature information, the distance information and the transition probability information, where the character prediction result comprises a probability score that the character indicated by the click operation belongs to the character corresponding to each key; and determining the character with a highest probability score as a correction character corresponding to the click operation.

Abstract: A method and system for locating a sound source are provide. The method may include detecting a sound signal of a sound by each of two audio sensors. The method may also include converting the sound signals detected by the two audio sensors from a time domain to a frequency domain. The method may further include determining a high frequency ratio of each of the sound signals in the frequency domain. The method may further include determining a direction of the sound source based on the high frequency ratios.

Abstract: A method and system for locating a sound source are provide. The method may include detecting a sound signal of a sound by each of two audio sensors. The method may also include converting the sound signals detected by the two audio sensors from a time domain to a frequency domain. The method may further include determining a high frequency ratio of each of the sound signals in the frequency domain. The method may further include determining a direction of the sound source based on the high frequency ratios.

Abstract: A method and an apparatus for detecting an abnormal situation are disclosed. The method includes detecting whether a first target exists in an obtained image; recognizing whether the first target holds an object, when the first target exists in the image; obtaining motion information of the object, when the first target holds the object; and determining, based on the motion information of the object, whether the abnormal situation exists.

Abstract: A method and system for locating a sound source are provide. The method may include detecting a sound signal of a sound by each of two audio sensors. The method may also include converting the sound signals detected by the two audio sensors from a time domain to a frequency domain. The method may further include determining a high frequency ratio of each of the sound signals in the frequency domain. The method may further include determining a direction of the sound source based on the high frequency ratios.