Patents by Inventor Gang-Qing Yao

Gang-Qing Yao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
    Patent number: 5808040
    Abstract: A method for stabilizing an oligonucleotide by including a .beta.-L-2'-deoxy-2'-fluoro-arabinofuranosyl nucleoside at the 5'-terminus, the 3'-terminus, or in the interior of the oligonucleotide. The oligonucleotide can be used in the modulation of gene expression through a process wherein a synthetic oligonucleotide is hybridized to a complementary nucleic acid sequence to inhibit transcription or replication of DNA or to inhibit translation or processing of RNA.
    Type: Grant
    Filed: January 24, 1997
    Date of Patent: September 15, 1998
    Assignees: Yale University, The University of Georgia Research Foundation, Inc.
    Inventors: Chung K. Chu, Yung-Chi Cheng, Balakrishna S. Pai, Gang-Qing Yao
  • Oligonucleotides containing L-nucleosides
    Patent number: 5753789
    Abstract: Oligonucleotides that include a 2'-fluoro .beta.-L-arabinofuranosyl nucleoside at the 3'-terminus, the 5'-terminus or in the interior of the oligomer. A preferred nucleoside is 2'-fluoro-5-methyl-.beta.-L-arabinofuranosyluridine (also referred to as L-FMAU). This compound is a potent antiviral agent against HBV and EBV and exhibits low cytotoxicity. Other specific examples of active compounds include N.sub.1 -(2'-deoxy-2'-fluoro-.beta.-L-arabinofuranosyl)-5-ethyluracil, N.sub.1 -(2'-deoxy-2'-fluoro-.beta.-L-arabinofuranosyl)-5-iodocytosine), and N.sub.1 -(2'-deoxy-2'-fluoro-.beta.-L-arabinofuranosyl)-5-iodouracil.
    Type: Grant
    Filed: July 26, 1996
    Date of Patent: May 19, 1998
    Assignees: Yale University, University of Georgia Research Found.
    Inventors: Chung K. Chu, Yung-Chi Cheng, Balakrishna S. Pai, Gang-Qing Yao
  • L-nucleosides
    Patent number: 5587362
    Abstract: A compound, and a pharmaceutical composition comprising an effective mount to treat HBV or EBV of a compound, of the formula: ##STR1## wherein R is selected from the group consisting of 5-methyluracil, adenine and cytosine, and R' is hydrogen, acyl, or alkyl or a monophosphate, diphosphate or triphosphate ester, or its pharmaceutically acceptable salt.
    Type: Grant
    Filed: January 28, 1994
    Date of Patent: December 24, 1996
    Assignees: Univ. of GA Research Foundation, Yale University
    Inventors: Chung K. Chu, Yung-Chi Cheng, Balakrishna S. Pai, Gang-Qing Yao