Abstract: Disclosed herein are novel bifunctional compounds formed by conjugating BTK inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

Abstract: A scheduling method and apparatus for an MU-MIMO system, an electronic apparatus, and a storage medium. The method comprises: acquiring a paired user group (30); receiving first uplink data from a first user (21), and receiving second uplink data from a second user (22); performing cyclic redundancy check after respectively demodulating the first uplink data and the second uplink data; when the first uplink data and the second uplink data are both successfully checked, scheduling the same resource for the first user (21) and the second user (22) according to a resource demand amount of the paired user group (30); and when checking of the first uplink data and/or the second uplink data fails, adjusting a pairing relationship of the paired user group (30).

Abstract: An ambient image projection device includes a light source assembly, a first projection mechanism and a second projection mechanism provided side by side; the first projection mechanism includes a display and a first optical module, a content played on the display is guided by the first optical module to form a dynamic image to be projected in space; the second projection mechanism includes an interference lens and a second optical module, light emitted from the light source assembly is guided by the second optical module to pass through the interference lens and forms an interference pattern to be projected in space; the interference pattern and the dynamic image overlap at least partially with each other in the space. The device provides more stereoscopic dynamic visual experience by projecting images via a display.

Abstract: An apparatus and system of providing resource allocation for PDSCH and/or PUSCH transmissions with multi-cell scheduling are described. For multi-cell scheduling, one or more of a carrier indicator, bandwidth part (BWP) indication, UL/SUL indicator, frequency domain resource allocation (FDRA) and/or time domain resource allocation (TDRA) may be provided by a NG-RAN node to a UE. In some cases, a carrier indication bitmap may be provided in downlink channel information to indicate single or multi-cell scheduling, as well as the scheduled cells.

Abstract: Provided are a novel fully human antibody for human B7H3, a chimeric antigen receptor, and uses thereof; also provided are a novel fully human anti-human B7H3 antibody, a chimeric antigen receptor containing the antibody, and genetically engineered cells expressing the receptor and the antibody. It has been verified by experiments that CAR-T, CAR-NK and CAR-iNKT cells targeting B7H3 prepared on the basis of the present chimeric antigen receptor have relatively strong proliferation ability, cytokine release ability and tumor cell killing ability, and can effectively eliminate tumor cells.

Abstract: Provided is an antibody or antigen-binding portion thereof that binds to CD70, comprising heavy chain CDRs selected from the group consisting of amino acid sequences SEQ ID NOs: 5, 6, 7, 15, 16, 22, 29, 30, 31, 37, 38, 44, 45, 46, 54, 55, 56, 64, 65, 77, 83, 84, 85, 91, 97, 98, 106, 107, 114, 115, 116, 124, 131, 132, 135, 142, 160 or any variant thereof, and/or light chain CDRs selected from the group consisting of amino acid sequences SEQ ID NOs: 10, 11, 12, 19, 25, 26, 34, 41, 49, 50, 51, 59, 60, 61, 68, 69, 74, 80, 88, 101, 102, 103, 110, 111, 119, 120, 121, 127, 128 or any variant thereof, which can block CD70-CD27 interaction and downstream signal conduction, and inhibit tumors. Also provided is a malignant tumor therapeutic agent containing the CD70 antibody, or antigen-binding portion thereof.

Abstract: The disclosure discloses an expression cassette for expressing a gene including overlapping open reading frames in an insect cell and an application thereof. The expression cassette includes from 5? to 3? and operably linked: a promoter capable of driving transcription in the insect cell; an artificially constructed sequence; the overlapping open reading frames missing only a first translation start codon; wherein the artificially constructed sequence includes a native or engineered intron with splicing activity in the insect cell, the intron includes ATG or the intron is located between any two adjacent nucleotides in ATG. A recombinant adeno-associated virus vector including the expression cassette of the disclosure regulates relative expressions of VP1, VP2, and VP3 proteins, and relative expressions of Rep78 and Rep52 proteins by using a designed intron sequence and through an intron splicing function for large-scale production of rAAV.

Abstract: The present disclosure provides a multi-view collaborative tracking method and apparatus for a fast moving target under a low luminance condition, including a multi-view target tracking algorithm based on radar-vision fusion data and an unmanned aerial vehicle (UAV) cluster collaborative tracking technology. This method takes the spatiotemporal normalized multi-source data as the learning objective of multi-agent reinforcement learning, to drive the cluster to collect data from multiple angles and directions. In this way, highly-efficient multi-angle collaborative observation can be performed on a high-speed moving object in an environment of weak texture and low luminance.

Abstract: Electronic paper includes a display panel and a drive component. The display panel may include a plurality of pixels disposed in a display region and a photoelectric conversion transistor disposed in a non-display region. The drive component is electrically connected to the plurality of pixels, and is electrically connected to a current output terminal of the photoelectric conversion transistor.

Abstract: This application provides a rotation shaft structure and an electronic device. The rotation shaft structure includes a main shaft assembly, and two folding assemblies. The folding assembly includes a rotation assembly, a support plate, and a housing mounting bracket. The rotation assembly is rotationally connected to the main shaft assembly. The support plate is rotationally connected to the housing mounting bracket and slidably connected to the rotation assembly. When two housing mounting brackets rotate toward each other, two support plates rotate in a same direction relative to the housing mounting brackets on corresponding sides, so that the two support plates and the main shaft assembly can form a triangle-like display accommodation space. When the electronic device is in a closed state, the display accommodation space can be used for accommodating a bent portion of the flexible display, so that the flexible display is not damaged by extrusion.

Abstract: An electric roasting machine includes a housing defining a cavity having an upper opening, a heating device installed in the cavity, and a grill located at the opening of the cavity. The grill includes a carrying part extending into the cavity and located in a region covered by thermal radiation of the heating device.

Abstract: A device and a method for simulating layered stratum containing natural gas hydrates are provided. The device includes a reactor; wherein the reactor includes an upper cover, a lower cover, and a reactor body, wherein the upper cover and the lower cover are sealably attached to two ends of the reactor body to form a closed chamber; an overlying pressure layer, a superstratum layer, a hydrate layer and a substratum layer are sequentially formed throughout inside of the closed chamber from the upper cover to the lower cover, wherein each layer is respectively filled with different kinds of porous media and fluids and the each layer is provided with a stratal-fluid annular container; each stratal-fluid annular container has an outer periphery contacting an inner surface of the reactor body. The method is conducted using the device.

Abstract: A system and method for exploiting a marine natural gas hydrate resource including a vertical well, comprising a sleeve configured to penetrate through a marine layer and a hydrate reservoir covering layer, and penetrate downwards into a natural gas hydrate reservoir; a section of the sleeve in the natural gas hydrate reservoir is provided with a perforating channel; a horizontal well, connected to a bottom end of the sleeve; a production string, disposed in the sleeve and extending downwards into the horizontal well, wherein a bottom of the production string is provided with a gas/water collection inlet; a hot water injection pipe, disposed in the production string; and a bottom of the hot water injection pipe is provided with a hot water injection opening; and a gas bladder, disposed in the horizontal well and connected to the hot water injection opening in the hot water injection pipe.

Abstract: A silicon-on-insulator metal-oxide-semiconductor field-effect transistor (SOI MOSFET) structure is provided, including a substrate layer; a buried oxide layer which is arranged on an upper surface of the substrate layer and is made of SiO2; an active zone which is arranged on an upper surface of the buried oxide layer; a source electrode and a drain electrode which are arranged on an upper surface of the active zone; a gate dielectric layer which is arranged between the source electrode and the drain electrode; a gate electrode which is provided in the gate dielectric layer; and a heat conduction column which penetrates through the buried oxide layer, and its top wall is in contact with the active zone. The heat conduction column dissipates heat in the active zone, resulting in a lattice temperature of the active zone will not increase extremely and avoiding a decrease of a current of the drain electrode.

Abstract: A time-of-flight camera module and a display device are provided. The time-of-flight module includes: a first carrier board, a second carrier board, a structure support, an infrared laser emission unit, a lens and a time-of-flight sensor. The first carrier board, the structure support and the second carrier board are stacked, and the first carrier board and the second carrier board are fixed on both sides of the structure support, respectively. The infrared laser emission unit is arranged on a side of the first carrier board away from the structure support, and the first carrier board includes a lens via hole located on a side of the infrared laser emission unit, the structure support includes a support via hole corresponding to the lens via hole, and the lens passes through the support via hole. The time-of-flight sensor is arranged on the second carrier board and is configured to sense infrared light collected by the lens to generate depth information.

Abstract: The embodiments of the present application provide a method and an apparatus for predicting an average energy consumption of an electric vehicle.

Abstract: Embodiments of the present application provide a feeding device for loading a material into a container, which relates to the technical field of product assembly. The feeding device is configured to load a material into a container having an opening. The feeding device includes a pressing unit. The pressing unit includes a pressing member having a pressing plane, and a driving member configured to drive the pressing member to move cyclically along a closed track. The closed track includes a first planar track segment, and when the pressing member moves along the first planar track segment, the pressing plane forms surface contact with the material and keeps extending in a material loading direction, the material loading direction being a movement direction of the material relative to the container. The feeding device can reduce damage to the material during a feeding process.

Abstract: The disclosure relates to KRAS inhibitor compounds having the structure of Formula (I), pharmaceutical compositions thereof, and methods of use thereof for inhibiting, treating, and/or preventing KRAS-associated diseases, disorders and conditions.

Abstract: Embodiments of the present disclosure relate to a method and apparatus of transmitting a reference signal and a method and apparatus of receiving a reference signal. In one embodiment of the present disclosure, the method of transmitting a reference comprises receiving a reference signal configuration indication, wherein reference signal resources are divided into at least two reference signal groups, and the reference signal configuration indication indicates a reference signal configuration including a reference signal group configuration; and transmitting the reference signal using a reference signal sequence in a reference signal group as indicated by the reference signal group configuration, wherein the reference signal sequence can be multiplexed with another layer or another user in different reference signal groups.