Abstract: A compound for degrading a Wee1 protein kinase or a pharmaceutically acceptable salt thereof, and the use thereof in the treatment of proliferative diseases.

Abstract: An unnatural amino acid may have a structure as shown in formula (1) or may be an enantiomer thereof: Such unnatural amino acid may be used, e.g., in recombinant proteins. A recombinant protein may contain such unnatural amino acid and a protein conjugate prepared from the recombinant protein. The unnatural amino acid can be simple and convenient to prepare, safe in nature, difficult to inactivate when inserted into a protein, and may have a high binding rate with a coupling moiety, and the obtained conjugate is higher in stability. The unnatural amino acid is applicable to numerous fields, especially in preparation of a recombinant protein or a recombinant protein conjugate.

Abstract: The present invention provides a freeze-dried composition containing anti-HER2 drug conjugate, which comprises ARX788 and one or more of pharmaceutically acceptable lyoprotectant, buffer salts and surfactants, wherein the pH value of the freeze-dried composition is from 5.7 to 6.3. The present invention also provides a freeze-dried preparation containing anti-HER2 drug conjugate and the preparation method thereof. The present invention also provides use of the freeze-dried composition and the freeze-dried preparation. The freeze-dried composition and the freeze-dried preparation provided by the present invention have a very excellent stability, as well as good appearance, short reconstitution time and low moisture content. The product quality is safe and reliable, and the production efficiency is high.

Abstract: A high laser damage threshold reflective optically addressed liquid crystal spatial light modulator for shaping 1053 nm linearly polarized light beams, comprising a computer-controlled LCoS electrical addressable spatial light modulator, polarization beam splitter, and polarizer, Liquid crystal cell, analyzer, AC power supply, where the liquid crystal cell comprises a transparent conductive film antireflection film layer, a transparent conductive film base layer, a first transparent conductive layer, a liquid crystal alignment layer, a liquid crystal layer, an alignment element, a reflective film layer, a light guide layer, and a second transparent conductive layer. By changing the transparent conductive layer material of the light-transmitting part of the liquid crystal cell from ITO to gallium nitride material, the damage threshold of the high-energy laser is improved, which facilitates application of beam shaping in high-power laser devices.

Abstract: An immunoblotting instrument and a control method are provided. The immunoblotting instrument comprises an immunoblotting instrument body, and an immunoblotting instrument control device, an incubation device and a liquid feeding and sucking device that are provided on the immunoblotting instrument body, and further comprises a temperature control device for controlling the incubation environment temperature of the immunoblotting membrane.

Abstract: A high laser damage threshold reflective optically addressed liquid crystal spatial light modulator for shaping 1053 nm linearly polarized light beams, comprising a computer-controlled LCoS electrical addressable spatial light modulator, polarization beam splitter, and polarizer, Liquid crystal cell, analyzer, AC power supply, where the liquid crystal cell comprises a transparent conductive film antireflection film layer, a transparent conductive film base layer, a first transparent conductive layer, a liquid crystal alignment layer, a liquid crystal layer, an alignment element, a reflective film layer, a light guide layer, and a second transparent conductive layer. By changing the transparent conductive layer material of the light-transmitting part of the liquid crystal cell from ITO to gallium nitride material, the damage threshold of the high-energy laser is improved, which facilitates application of beam shaping in high-power laser devices.

Abstract: A method and an apparatus for adding tokens in traffic shaping are provided. According to the method, a weight of each data stream is configured, and each data stream is added to corresponding token schedulers based on the weight of the each data stream. Based on a weight of each token scheduler, each token scheduler is sequentially added to corresponding token scheduler groups, and all the token scheduler groups are aggregated into a token scheduler of a total data stream. The token scheduler of the total data stream is added to a top token scheduler. Based on a preset cycle, a token is assigned to the token scheduler of the total data stream in the top token scheduler, and the assigned token is delivered to each token scheduler group or to a respective data stream.

Abstract: A method and an apparatus for adding tokens in traffic shaping are provided. According to the method, a weight of each data stream is configured, and each data stream is added to corresponding token schedulers based on the weight of the each data stream. Based on a weight of each token scheduler, each token scheduler is sequentially added to corresponding token scheduler groups, and all the token scheduler groups are aggregated into a token scheduler of a total data stream. The token scheduler of the total data stream is added to a top token scheduler. Based on a preset cycle, a token is assigned to the token scheduler of the total data stream in the top token scheduler, and the assigned token is delivered to each token scheduler group or to a respective data stream.

Abstract: An electrostatic precipitator cell containing a collection assembly, a plurality of collection assembly ground plates disposed in the collection assembly, a plurality of banks disposed in the collection assembly, wherein each bank containing a collection assembly charge plate and a voltage isolator is described. Electrically isolating portions of an electrostatic precipitator cell results in reduced arcing and overall increases in cleaning efficiency. As air cleaner utilizing the electrostatic precipitator with isolated banks is also described.

Abstract: A single ended forward DC-to-DC converter includes a transformer having a. primary winding electrically connected to a primary switch and a secondary winding electrically connected to a secondary switch and a clamping capacitor. The clamping capacitor stores the magnetization energy from the secondary winding when the primary switch is turned off, thus causing the transformer core to be reset during the period that the primary switch remains off. The converter can use mosfets as the primary and secondary switches, such that a change in the voltage at the secondary winding of the transformer, due to the turning off of the primary switch, results in an automatic turning on of the secondary switch. The combination of the clamping capacitor and the mosfet switches increases the simplicity of the DC-to-DC converter while eliminating undesirable characteristics such as dead time and voltage stresses on the switches.

Abstract: A synchronous rectification circuit for a DC-DC power converter can operate efficiently with a primary drive voltage that remains at a zero voltage level during a portion of the power conduction cycle. The DC-DC power converter includes a primary side power circuit providing a symmetrically varying power signal that remains at a zero voltage level for a portion of a conduction cycle. A first secondary side power circuit is inductively coupled to the primary side power circuit, and has an output terminal that provides an output voltage. The first secondary side power circuit further comprises first and second synchronous rectifiers having respective activation terminals. The synchronous rectifiers are adapted to alternately activate in synchronism with non-zero voltage level portions of the conduction cycle. A second secondary side power circuit is inductively coupled to the first secondary side power circuit and has polarity reversed with respect to the first secondary side power circuit.

Abstract: A single ended forward DC-to-DC converter includes a transformer having a primary winding electrically connected to a primary switch and a secondary winding electrically connected to a secondary switch and a clamping capacitor. The clamping capacitor stores the magnetization energy from the secondary winding when the primary switch is turned off, thus causing the transformer core to be reset during the period that the primary switch remains off. The converter can use mosfets as the primary and secondary switches, such that a change in the voltage at the secondary winding of the transformer, due to the turning off of the primary switch, results in an automatic turning on of the secondary switch. The combination of the clamping capacitor and the mosfet switches increases the simplicity of the DC-to-DC converter while eliminating undesirable characteristics such as dead time and voltage stresses on the switches.

Abstract: A single ended forward DC-to-DC converter includes a transformer having a primary winding electrically connected to a primary switch and a secondary winding electrically connected to a secondary switch and a clamping capacitor. The clamping capacitor stores the magnetization energy from the secondary winding when the primary switch is turned off, thus causing the transformer core to be reset during the period that the primary switch remains off. The converter can use mosfets as the primary and secondary switches, such that a change in the voltage at the secondary winding of the transformer, due to the turning off of the primary switch, results in an automatic turning on of the secondary switch. The combination of the clamping capacitor and the mosfet switches increases the simplicity of the DC-to-DC converter while eliminating undesirable characteristics such as dead time and voltage stresses on the switches.

Abstract: A single ended forward DC-to-DC converter includes a transformer having a primary winding electrically connected to a primary switch and a secondary winding electrically connected to a secondary switch and a clamping capacitor. The clamping capacitor stores the magnetization energy from the secondary winding when the primary switch is turned off, thus causing the transformer core to be reset during the period that the primary switch remains off. The converter can use mosfets as the primary and secondary switches, such that a change in the voltage at the secondary winding of the transformer, due to the turning off of the primary switch, results in an automatic turning on of the secondary switch. The combination of the clamping capacitor and the mosfet switches increases the simplicity of the DC-to-DC converter while eliminating undesirable characteristics such as dead time and voltage stresses on the switches.

Abstract: A single ended forward DC-to-DC converter includes a transformer having a primary winding electrically connected to a primary switch and a secondary winding electrically connected to a secondary switch and a clamping capacitor. The clamping capacitor stores the magnetization energy from the secondary winding when the primary switch is turned off, thus causing the transformer core to be reset during the period that the primary switch remains off. The converter can use mosfets as the primary and secondary switches, such that a change in the voltage at the secondary winding of the transformer, due to the turning off of the primary switch, results in an automatic turning on of the secondary switch. The combination of the clamping capacitor and the mosfet switches increases the simplicity of the DC-to-DC converter while eliminating undesirable characteristics such as dead time and voltage stresses on the switches.