Abstract: The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.

Abstract: Compounds for targeting and agents for imaging, prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.

Abstract: Disclosed is a compound of formula (I), and a stereoisomer, a pharmaceutically acceptable salt, a solvate, a co-crystal or a deuterated product thereof, or a pharmaceutical composition containing same, and the use thereof as a CD73 antagonist in the preparation of a drug for treating related diseases, wherein the definition of each group in formula (I) is consistent with the definition in the description.

Abstract: The present disclosure provides a semiconductor device and a fabricating method thereof includes a source structure, a drain structure, a gate structure, a bottom dielectric layer, a gate dielectric layer, a channel structure, and a metal nitride layer. The source structure and the drain structure are stacked in a vertical direction, and the gate structure is between the drain structure and the source structure. The bottom dielectric layer is disposed between the drain structure and the source structure. The channel structure is disposed between the drain structure and the source structure and is electrically connected the drain structure and the source structure, and the channel structure is partially disposed in the gate structure. The gate dielectric layer is disposed between the channel structure and the gate structure. The metal nitride layer is disposed between the gate dielectric layer and the gate structure.

Abstract: Compounds for targeting and agents for imaging, prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.

Abstract: Disclosed herein are systems, methods and devices for controlling output of a storage device during read operations. The method comprises: measuring a length of a temporal gap between first and second consecutive read bursts from a storage device, the first and second read burst are in response to first and second read commands received by the storage device, respectively; generating a state code according to the length, wherein the state code has a first value when the length is zero, a second value when the length is equal to or shorter than a threshold time length but is non-zero, and a third value when the length is greater than the threshold time length; and controlling output of the storage device according to the state code.

Abstract: Disclosed is a fastening assembly, comprising a fastening element, a compensation element, a holding element, and a limiting element. A limiting portion of the fastening element is provided at a head or between the head and a threaded portion and protrudes outward relative to an outer peripheral surface of the head. The compensation element includes a main body and a receiving hole running therethrough. The main body is provided with a limiting flange to stop the fastening element, and the compensation element can be connected to a first component and move relative to the first component in a longitudinal direction. The holding element at least partially surrounds the head.

Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine analogs, methods of making, and uses of the same. In particular, polyvalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.

Abstract: Disclosed herein are WD40 repeat domain protein 5 (WDR5) degradation/disruption compounds including a WDR5 ligand, a degradation/disruption tag, and a linker, and methods of using such compounds in the treatment of WDR5-mediated diseases.

Abstract: The present invention relates to a vehicle data communication and interaction system and a construction method thereof. The system includes a first test vehicle placed in an environment perception test platform and a second test vehicle placed in a rotating hub test platform, an intelligent-electronic control unit (i-ECU), a vehicle control unit (VCU), and a vehicle bottom electronic control unit that are communicatively connected with each other are mounted on each of the first test vehicle and the second test vehicle, and a sensor is further mounted on the first test vehicle. The first test vehicle is communicatively connected to the second test vehicle, and specifically, the VCU or a network gateway is connected via the sensor, to implement a communication connection between the two test vehicles.

Abstract: A light-emitting diode device and a manufacturing method therefor, and a display panel and a display apparatus. The light-emitting diode device comprises a quantum dot light-emitting layer, and a hole transport layer located at one side of the quantum dot light-emitting layer, wherein the hole transport layer comprises a perovskite material and an organic hole transport material. The high carrier mobility of a perovskite material can improve the carrier transport performance of a hole transport layer.

Abstract: A whole vehicle in-loop test system of an intelligent automobile, including: a rotary drum platform, used for simulating a longitudinal movement of a test vehicle; an environment perception platform, disposed at a front end of the rotary drum platform, used for simulating a transverse movement of a test vehicle, and including a support base at a lower portion and a vehicle placing platform at an upper portion, where a transverse drive wheel is mounted at the lower portion of the support base, and the transverse drive wheel moves along a transverse track disposed on the ground; and a target vehicle simulation unit, disposed at a periphery of the environment perception platform, and configured to simulate a target vehicle.

Abstract: Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets.

Abstract: A projection apparatus and a control method thereof are provided. The projection apparatus includes a processor, a sensor, and a projection module. When a command corresponding to a standby mode is received, the processor sets the projection apparatus to a first sub-standby mode. The sensor is enabled to sense whether there is a living object located in a sensing area outside the projection apparatus. The standby mode is maintained as the first sub-standby mode in response to sensing that the living object is not in the sensing area. The standby mode is set to be switched to a second sub-standby mode in response to sensing that the living object is in the sensing area. A maximum power consumption of the first sub-standby mode is less than a maximum power consumption of the second sub-standby mode. In the first and second sub-standby modes, the projection module is not enabled.

Abstract: A cultivation method for drip irrigation of cotton fields in saline-alkali soil is provided, belonging to the field of agricultural planting technologies. It mainly includes performing land preparation; setting a planting mode; laying tubes; performing a high frequency drip irrigation; fertilizing with water; performing intertillage; performing chemical control; and performing green prevention and control.

Abstract: The disclosure provides a ventilation apparatus. The ventilation apparatus includes a housing, an inhalation branch, a control unit, a gas source port, an exhalation branch, and a paramagnetic oxygen sensor. The paramagnetic oxygen sensor is used for detecting the oxygen content in the inhalation branch. The gas source port is disposed on the housing. The inhalation branch, the control unit, and the exhalation branch are enclosed within the housing. The paramagnetic oxygen sensor is disposed outside the housing.

Abstract: An image processing method is performed by a processor. The image processing method includes following operations: generating an average brightness value of each of a plurality windows in image data; generating a pixel ratio value according to the image data; generating a weight value of the each of the windows according to the pixel ratio value, a first brightness weight, and a second brightness weight; generating an adjusted brightness value according to the average brightness values of the windows and the weight values of the windows; and performing an auto exposure process according to the adjusted brightness value to generate final image data. The final image data is for a display panel to display.

Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.

Abstract: A FET with a multi-value switching function comprises a source region, a channel region, a drain region, a gate dielectric layer, a substrate layer, a gate-oxide inducer layer, a metal layer and a spacer layer. The channel region is an undoped channel region, the drain region is an undoped drain region. The metal layer comprises first to third metal blocks which are arranged at intervals from left to right, the distance between the first metal block and the second metal block is 12 nm, the distance between the second metal block and the third metal block is 10 nm, the first metal block is a main control gate of the FET, the second metal block and the third metal block are two inducer gates of the FET, and the spacer layer is used for isolating the first metal block from the second metal block and the third metal block.

Abstract: A system and a method identify an adverse geological body in a tunnel based on hyperspectral technology analysis. The system includes a wall-climbing robot, a controller, and a signal processor, wherein the wall-climbing robot is provided with a plurality of groups of hyperspectral light sources and receivers, and the hyperspectral light sources and the receivers are arranged at intervals; the controller is configured to control the operation of the wall-climbing robot to ensure that the wall-climbing robot moves on a tunnel face according to a set spiral path; and the signal processor communicates with the receivers to receive the acquired spectrum data, draws a mineral distribution map of the tunnel face with the path raveled by the wall-climbing robot as a plane, and identifies an adverse geological body by identifying categories and distribution characteristics of the representative minerals.