Abstract: The disclosed embodiments provide a system that performs molecular assembly. During operation, the system delivers one or more droplets of a fluid onto a surface using a nanofluidic delivery probe and an associated high-precision positioning device, wherein the solution comprises a solvent and one or more solute molecules, and wherein delivery of the droplets onto the surface facilitates evaporation-driven assembly of one or more structures on the surface. Moreover, while delivering a droplet onto the surface, the system controls a size of the droplet and a shape of the droplet during evaporation to produce a variety of shapes in resulting structures.

Abstract: The disclosed embodiments provide a system that forms a three-dimensional (3D) nanostructure through 3D printing. During operation, the system performs a 3D printing operation that uses multiple passes of a scanning probe microscope (SPM) tip to deliver an ink to form the 3D nanostructure, wherein the ink includes both a positively charged polyelectrolyte (PE) and a negatively charged PE. While delivering the ink, the SPM tip is loaded with the ink and moved to a target location to deposit the ink. Finally, after the multiple passes are complete, the system cures the 3D nanostructure to remove excess positive or negative charges from the 3D nanostructure.

Abstract: The present invention provides amyloid fibrils comprising a plurality of modified ? solenoid protein (mBSP) monomers. The mBSP monomers are modified to enhance self-assembly and are useful in a variety of applications.

Abstract: The disclosed embodiments provide a system that forms a three-dimensional (3D) nanostructure through 3D printing. During operation, the system performs a 3D printing operation that uses multiple passes of a scanning probe microscope (SPM) tip to deliver an ink to form the 3D nanostructure, wherein the ink includes both a positively charged polyelectrolyte (PE) and a negatively charged PE. While delivering the ink, the SPM tip is loaded with the ink and moved to a target location to deposit the ink. Finally, after the multiple passes are complete, the system cures the 3D nanostructure to remove excess positive or negative charges from the 3D nanostructure.

Abstract: The present invention provides amyloid fibrils comprising a plurality of modified ? solenoid protein (mBSP) monomers. The mBSP monomers are modified to enhance self-assembly and are useful in a variety of applications.

Abstract: One embodiment of the present invention provides a system that measures single cell mechanics using a scanning probe microscope. During operation, the system positions a modified probe of the scanning probe microscope above a cell which is located on a surface, wherein the modified probe is configured with a geometry for compressing the cell. The system then comprises the cell against the surface using the modified probe, thereby causing the cell to deform. Next, the system extracts mechanical properties of the cell from cell deformation behavior and cell response to the compression force.

Abstract: One embodiment of the present invention provides a system that measures single cell mechanics using a scanning probe microscope. During operation, the system positions a modified probe of the scanning probe microscope above a cell which is located on a surface, wherein the modified probe is configured with a geometry for compressing the cell. The system then comprises the cell against the surface using the modified probe, thereby causing the cell to deform. Next, the system extracts mechanical properties of the cell from cell deformation behavior and cell response to the compression force.

Abstract: A stepwise contraction and adsorption nanolithography (SCAN) patterning process can shrink complex microstructures (produced by current microfabrication technology) into the nanometer region. The basis of SCAN is to transfer a pre-engineered microstructure onto a extended elastomer. This extended elastomer is then allowed to relax, reducing the microstructure accordingly. The new miniaturized structure is then used as a stamp to transfer the structure onto another stretched elastomer. Through iterations of this procedure, patterns of materials with pre-designed geometry are miniaturized to the desired dimensions, including sub-100 ran. The simplicity and high throughput capability of SCAN make the platform a competitive alternative to other micro- and nanolithography techniques for potential applications in multiplexed sensors, non-binary optical displays, biochips, nanoelectronics devices, and microfluidic devices.

Abstract: Self-assembled monolayers and other solid support/surface-layer systems are widely used as resists for nanofabrication because of its closely packed structure, low defect density, and uniform thickness. However these resists suffer the drawback of low stability in liquid due to desorption and/or oxidation induced desorption. Stabilized solid support/surface-layer systems and methods of preserving the integrity and structure of self-assembled monolayers on solid surfaces are provided. The method involves adding small amount of amphiphilic molecules, such as DMF and DMSO, into aqueous solutions as preserving media. These molecules adhere favorably to defect sites within monolayers and inhibit the initiation of both known degradation pathways: oxidation and desorption. Also provided are stabilized systems including the solid support/surface-layer system and stabilizing solution, as well as kits of stabilizing solutions for use with various systems.

Abstract: A method for fabricating thin film nanostructures is provided. A layer of material on a substrate is mechanically displaced using an atomic force microscopy tip. The displacement is carried out in a fluid containing molecules which rapidly enter the void created by the AFM tip and bind to the clean substrate surface. These molecules are spatially confined in the void created by the displacement and form inlaid structures within the surrounding material. The surrounding material can be removed to create islands of the new material. The method is particularly adapted for use in fabricating nanometer-scale microelectronic devices.