Patents by Inventor Gangjun Liu
Gangjun Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11896525Abstract: Disclosed is a handheld laser probe for laser thermal conjunctivoplasty, the handheld laser comprising: a forceps; and a line focused laser light source coupled to the forceps, wherein the forceps are configured to grasp a conjunctival fold and hold the fold in a light beam of the line focused laser, and wherein the line focused laser beam is configured to uniformly heat the conjunctival fold held in the forceps. Disclosed are systems for laser thermal conjunctivoplasty including the handheld laser. Disclosed are methods of conjunctivoplasty using the handheld laser probe.Type: GrantFiled: February 27, 2018Date of Patent: February 13, 2024Assignees: OREGON HEALTH & SCIENCE UNIVERSITY, BAYLOR COLLEGE OF MEDICINEInventors: David Huang, Gangjun Liu, Jianlong Yang, Stephen Pflugfelder
-
Publication number: 20240009032Abstract: Disclosed is a handheld laser probe for laser thermal conjunctivoplasty, the handheld laser comprising: a forceps; and a line focused laser light source coupled to the forceps, wherein the forceps are configured to grasp a conjunctival fold and hold the fold in a light beam of the line focused laser, and wherein the line focused laser beam is configured to uniformly heat the conjunctival fold held in the forceps. Disclosed are systems for laser thermal conjunctivoplasty including the handheld laser. Disclosed are methods of conjunctivoplasty using the handheld laser probe.Type: ApplicationFiled: September 26, 2023Publication date: January 11, 2024Applicant: Oregon Health & Science UniversityInventors: David Huang, Gangjun Liu, Jianlong Yang, Stephen Pflugfelder
-
Publication number: 20230069484Abstract: Disclosed are systems and methods for generating wide-field optical coherence tomography angiography (OCTA) images. In embodiments, multiple OCTA scans of a sample are automatically acquired at overlapping locations. The systems and methods include functionality to adaptively control the scanning procedure such that eye blink and eye motion events are detected in real time and accounted for during 3D scan acquisition. Also disclosed are methods for detecting and correcting motion-related artifacts in OCTA datasets which allow for the longer scan times over larger fields of view required for wide-field imaging. These methods may include division of en face angiogram images into a set of motion-free parallel strips, and application of gross and fine registration methods to align overlapping strips into a motion- corrected composite image. A series of overlapping motion-corrected composite images may be combined into a larger montage to enable wide-field OCTA imaging using multiple OCTA scans.Type: ApplicationFiled: September 6, 2022Publication date: March 2, 2023Applicant: Oregon Health & Science UniversityInventors: David Huang, Gangjun Liu, Yali Jia
-
Patent number: 11452442Abstract: Disclosed are systems and methods for generating wide-field optical coherence tomography angiography (OCTA) images. In embodiments, multiple OCTA scans of a sample are automatically acquired at overlapping locations. The systems and methods include functionality to adaptively control the scanning procedure such that eye blink and eye motion events are detected in real time and accounted for during 3D scan acquisition. Also disclosed are methods for detecting and correcting motion-related artifacts in OCTA datasets which allow for the longer scan times over larger fields of view required for wide-field imaging. These methods may include division of en face angiogram images into a set of motion-free parallel strips, and application of gross and fine registration methods to align overlapping strips into a motion-corrected composite image. A series of overlapping motion-corrected composite images may be combined into a larger montage to enable wide-field OCTA imaging using multiple OCTA scans.Type: GrantFiled: June 15, 2017Date of Patent: September 27, 2022Assignee: OREGON HEALTH & SCIENCE UNIVERSITYInventors: David Huang, Gangjun Liu, Yali Jia
-
Publication number: 20200345284Abstract: The present application discloses a multi-spectral fundus imaging system and method using dynamic visual stimulation, where the imaging system includes: a multi-spectral light source capable of emitting multiple different wavelengths; a mid-pass mirror being a reflecting mirror with a central hole penetrating the reflecting mirror; an imaging focusing lens group; an image acquisition device; and a controller configured to control the multi-spectral light source and the image acquisition device to work synchronously; a pattern sent by the optical stimulation device is transmitted to the fundus through the image focusing lens group and the central hole of the mid-pass mirror in sequence; an imaging light reflected from the fundus passes through the central hole of the mid-pass mirror and the imaging focusing lens group in sequence; the image acquisition device acquires the image to complete a multi-spectral fundus image acquisition.Type: ApplicationFiled: January 15, 2019Publication date: November 5, 2020Inventors: Jun Tao, Gangjun Liu, Wenchao Yu
-
Patent number: 10568687Abstract: A multimodal medical device for the diagnosis and/or thermal treatment of a disease includes an instrument for performing thermal therapy; and an imaging system having multiple tomographic imaging modes, including optical coherence tomography (OCT), ultrasound imaging, photoacoustic (PA) imaging, fluorescence imaging and/or thermal imaging to provide guidance for accurate diagnosis and treatment of the disease.Type: GrantFiled: January 15, 2016Date of Patent: February 25, 2020Assignees: The Regents of the University of California, Med-X institute Shanghai Jiao Tong UniversityInventors: Zhongping Chen, Gangjun Liu, Jiawen Li, Lisa X. Xu, Aili Zhang
-
Publication number: 20200030141Abstract: Disclosed is a handheld laser probe for laser thermal conjunctivoplasty, the handheld laser comprising: a forceps; and a line focused laser light source coupled to the forceps, wherein the forceps are configured to grasp a conjunctival fold and hold the fold in a light beam of the line focused laser, and wherein the line focused laser beam is configured to uniformly heat the conjunctival fold held in the forceps. Disclosed are systems for laser thermal conjunctivoplasty including the handheld laser. Disclosed are methods of conjunctivoplasty using the handheld laser probe.Type: ApplicationFiled: February 27, 2018Publication date: January 30, 2020Applicant: Oregon Health & Science UniversityInventors: David Huang, Gangjun Liu, Jianlong Yang, Stephen Pflugfelder
-
Patent number: 10327631Abstract: Disclosed herein are methods and systems for aligning swept-source optical coherence tomography (SS-OCT) spectral interferograms to a reference spectral interferogram based on signal information (e.g., amplitude or phase) at a fixed-pattern noise location to reduce residual fixed-pattern noise and improve the phase stability of SS-OCT systems.Type: GrantFiled: January 14, 2016Date of Patent: June 25, 2019Assignee: Oregon Health & Science UniversityInventors: David Huang, Gangjun Liu
-
Publication number: 20190150729Abstract: Disclosed are systems and methods for generating wide-field optical coherence tomography angiography (OCTA) images. In embodiments, multiple OCTA scans of a sample are automatically acquired at overlapping locations. The systems and methods include functionality to adaptively control the scanning procedure such that eye blink and eye motion events are detected in real time and accounted for during 3D scan acquisition. Also disclosed are methods for detecting and correcting motion-related artifacts in OCTA datasets which allow for the longer scan times over larger fields of view required for wide-field imaging. These methods may include division of en face angiogram images into a set of motion-free parallel strips, and application of gross and fine registration methods to align overlapping strips into a motion-corrected composite image. A series of overlapping motion-corrected composite images may be combined into a larger montage to enable wide-field OCTA imaging using multiple OCTA scans.Type: ApplicationFiled: June 15, 2017Publication date: May 23, 2019Applicant: Oregon Health & Science UniversityInventors: David Huang, Gangjun Liu, Yali Jia
-
Publication number: 20160317020Abstract: Disclosed are methods of imaging vascular flow using optical coherence tomography. The methods involve calculating an OCT phase difference and an OCT phase gradient from interference fringes acquired from B-scans. The methods can be implemented in a split-spectrum embodiment to enhance the signal to noise ratio of vascular flow images. The methods also obviate the need for correction of bulk motion and laser trigger jitter-induced phase artifacts.Type: ApplicationFiled: April 28, 2016Publication date: November 3, 2016Applicant: OREGON HEALTH & SCIENCE UNIVERSITYInventors: Gangjun Liu, David Huang, Yali Jia
-
Publication number: 20160232427Abstract: Methods and systems for detecting a gold nanorod (GNR) contrast agent in an optical coherence tomography (OCT) image of a sample are disclosed. In one example approach, a method comprises separating the OCT image at the location into short and long wavelength halves around a center wavelength of the OCT system, calculating a ratio between the short and long wavelength halves, and indicating a gold nanorod contrast agent at the location based on the ratio. In some examples, spectral fractionation may be employed to further divide the short and long wavelength halves into sub-bands to increase spectral contrast, reduce noise, and increase accuracy in detecting GNR in a sample.Type: ApplicationFiled: November 3, 2015Publication date: August 11, 2016Applicants: VANDERBILT UNIVERSITY, OREGON HEALTH & SCIENCE UNIVERSITYInventors: David HUANG, Yali JIA, Ashwath JAYAGOPAL, Gangjun LIU
-
Publication number: 20160206195Abstract: Disclosed herein are methods and systems for aligning swept-source optical coherence tomography (SS-OCT) spectral interferograms to a reference spectral interferogram based on signal information (e.g., amplitude or phase) at a fixed-pattern noise location to reduce residual fixed-pattern noise and improve the phase stability of SS-OCT systems.Type: ApplicationFiled: January 14, 2016Publication date: July 21, 2016Applicant: Oregon Health & Science UniversityInventors: David Huang, Gangjun Liu
-
Publication number: 20160206373Abstract: A multimodal medical device for the diagnosis and/or thermal treatment of a disease includes an instrument for performing thermal therapy; and an imaging system having multiple tomographic imaging modes, including optical coherence tomography (OCT), ultrasound imaging, photoacoustic (PA) imaging, fluorescence imaging and/or thermal imaging to provide guidance for accurate diagnosis and treatment of the disease.Type: ApplicationFiled: January 15, 2016Publication date: July 21, 2016Applicants: The Regents of the University of California, Med-X institute Shanghai Jiao Tong UniversityInventors: Zhongping Chen, Gangjun Liu, Jiawen Li, LIsa X. Xu, Aili Zhang
-
Patent number: 9384404Abstract: A method using optical coherence tomography to capture the microvascular network of the superficial layer of the finger skin for the purpose of fingerprint authentication and liveness detection. At the dermal papilla region, the vascular pattern follows the same pattern of the fingerprint and this vascular pattern forms a live vascular fingerprint. This live vascular fingerprint provides for ultrahigh security and a unique way for fingerprint-based personal verification. Because the system is based on blood flow, which only exists in a living person, the technique is robust against spoof attaching. After performing non-contact in-vivo imaging of a human fingertip, a three dimensional vasculature image is reconstructed from a plurality of vasculature tomography images and at least one vasculature fingerprint image which corresponds to the fingertip is extracted from the three dimensional vasculature image.Type: GrantFiled: February 28, 2014Date of Patent: July 5, 2016Assignee: The Regents of the University of CaliforniaInventors: Zhongping Chen, Gangjun Liu
-
Publication number: 20140241596Abstract: A method using optical coherence tomography to capture the microvascular network of the superficial layer of the finger skin for the purpose of fingerprint authentication and liveness detection. At the dermal papilla region, the vascular pattern follows the same pattern of the fingerprint and this vascular pattern forms a live vascular fingerprint. This live vascular fingerprint provides for ultrahigh security and a unique way for fingerprint-based personal verification. Because the system is based on blood flow, which only exists in a living person, the technique is robust against spoof attaching. After performing non-contact in-vivo imaging of a human fingertip, a three dimensional vasculature image is reconstructed from a plurality of vasculature tomography images and at least one vasculature fingerprint image which corresponds to the fingertip is extracted from the three dimensional vasculature image.Type: ApplicationFiled: February 28, 2014Publication date: August 28, 2014Applicant: The Regents of the University of CaliforniaInventors: Zhongping Chen, Gangjun Liu
-
Patent number: 8582096Abstract: A fiber-delivered probe suitable for CARS imaging of thick tissues is practical. The disclosed design is based on two advances. First, a major problem in CARS probe design is the presence of a very strong anti-Stokes component in silica delivery fibers generated through a FWM process. Without proper spectral filtering, this component affects the CARS image from the tissue sample. The illustrated embodiments of the invention efficiently suppress this spurious anti-Stokes component through the use of a separate fiber for excitation delivery and for signal detection, which allows the incorporation of dichroic optics for anti-Stokes rejection. Second, the detection of backscattered CARS radiation from the sample is optimized by using a large core multi mode fiber in the detection channel. This scheme produces high quality CARS images free of detector aperture effects. Miniaturization of this fiber-delivered probe results in a practical handheld probe for clinical CARS imaging.Type: GrantFiled: December 15, 2010Date of Patent: November 12, 2013Assignee: The Regents of the University of CaliforniaInventors: Zhongping Chen, Gangjun Liu, Mihael Balu, Bruce Tromberg, Eric Olaf Potma
-
Publication number: 20110282166Abstract: A fiber-delivered probe suitable for CARS imaging of thick tissues is practical. The disclosed design is based on two advances. First, a major problem in CARS probe design is the presence of a very strong anti-Stokes component in silica delivery fibers generated through a FWM process. Without proper spectral filtering, this component affects the CARS image from the tissue sample. The illustrated embodiments of the invention efficiently suppress this spurious anti-Stokes component through the use of a separate fiber for excitation delivery and for signal detection, which allows the incorporation of dichroic optics for anti-Stokes rejection. Second, the detection of backscattered CARS radiation from the sample is optimized by using a large core multi mode fiber in the detection channel. This scheme produces high quality CARS images free of detector aperture effects. Miniaturization of this fiber-delivered probe results in a practical handheld probe for clinical CARS imaging.Type: ApplicationFiled: December 15, 2010Publication date: November 17, 2011Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Zhongping Chen, Gangjun Liu, Mihael Balu, Bruce Tromberg, Eric Olaf Potma