Abstract: A mass spectrometer system an ion source configured to produce ions and a non-metallic capillary configured to receive at least a portion of the ions from the ion source. The capillary includes an elongated body and multiple bores traversing the elongated body in a longitudinal direction. The bores transport the received ions through the capillary toward a mass analyzer of the mass spectrometer system for detection.

Abstract: A gas chromatograph-mass spectrometer (GC-MS) system includes a multi-capillary GC column coupled to a mass analyzer through an ionization interface. The ionization interface includes an ionization device and an ion guide configured for receiving a high-capacity gas-sample flow from the GC column and transmitting a compressed ion beam to the mass analyzer. The ion beam may be converging.

Abstract: A gas chromatograph-mass spectrometer (GC-MS) system includes a multi-capillary GC column coupled to a mass analyzer through an ionization interface. The ionization interface includes an ionization device and an ion guide configured for receiving a high-capacity gas-sample flow from the GC column and transmitting a compressed ion beam to the mass analyzer. The ion beam may be converging.

Abstract: Devices and systems for reflecting ions are provided. In general, the devices and systems include a plurality of curved lens plates adapted for connection to at least one voltage source and having a passage therein to allow the ions to pass therethrough. The plurality of curved lens plates generates electric fields having elliptic equipotential surfaces that reflect and focus the ions as they pass through the passage. Reflectron time-of-flight (RE-TOF) spectrometers are also provided that include an ion source, ion detector, and such a reflectron as described above. Mass spectrometer systems are provided that comprise an ion source that generates ions and a reflectron TOF spectrometer such as described above.

Abstract: Devices and systems for reflecting ions are provided. In general, the devices and systems include a plurality of curved lens plates adapted for connection to at least one voltage source and having a passage therein to allow the ions to pass therethrough. The plurality of curved lens plates generates electric fields having elliptic equipotential surfaces that reflect and focus the ions as they pass through the passage. Reflectron time-of-flight (RE-TOF) spectrometers are also provided that include an ion source, ion detector, and such a reflectron as described above. Mass spectrometer systems are provided that comprise an ion source that generates ions and a reflectron TOF spectrometer such as described above.

Abstract: A mass spectrometer system an ion source configured to produce ions and a non-metallic capillary configured to receive at least a portion of the ions from the ion source. The capillary includes an elongated body and multiple bores traversing the elongated body in a longitudinal direction. The bores transport the received ions through the capillary toward a mass analyzer of the mass spectrometer system for detection.

Abstract: An ion source a first ionizer comprising: an electrospray needle comprising a tip; and a conduit disposed annularly about the needle and configured to pass an inert gas in proximity of the tip to nebulize a fluid emerging from the tip, the nebulized fluid comprising analytes and a mobile phase. The ion source comprises a capillary in tandem with the first ionizer and configured to receive the droplets; a heater configured to heat the capillary to a temperature at which mobile phase vaporizes; and a second ionizer in tandem with the capillary and configured to receive the vaporized mobile phase and the analytes. A method is also described.

Abstract: An ion source a first ionizer comprising: an electrospray needle comprising a tip; and a conduit disposed annularly about the needle and configured to pass an inert gas in proximity of the tip to nebulize a fluid emerging from the tip, the nebulized fluid comprising analytes and a mobile phase. The ion source comprises a capillary in tandem with the first ionizer and configured to receive the droplets; a heater configured to heat the capillary to a temperature at which mobile phase vaporizes; and a second ionizer in tandem with the capillary and configured to receive the vaporized mobile phase and the analytes. A method is also described.

Abstract: An electric field source for a mass spectrometer and a mass spectrometer are described.

Abstract: A device and a method for identifying metalloproteins are disclosed. The device includes a first separation device for separating sample molecules according to their retention times, a first ionization device for ionizing the separated molecules into molecular ions, a second separation device for separating the molecular ions by their size-to-charge ratio, a second ionization device for atomizing the molecular ions and creating atomic ions of interest, and a mass spectrometer for separating and identifying both the molecular ions and the atomic ions by their mass-to-charge ratios. A method includes separating sample molecules according to their retention time, ionizing the separated molecules to form molecular ions, separating the molecular ions according to their size-to-charge ratio, atomizing and ionizing a portion of the molecular ions and identifying the atomic and molecular ions by their mass-to-charge ratio.

Abstract: In accordance with the invention, auxiliary structures are used in conjunction with a microfluidic chip to form a microfluidic electrospray structure that allows gas assisted nebulization for use in a mass spectrometry system.

Abstract: The invention provides an ion extraction pulser. The ion extraction pulser may be used independently or in conjunction with a mass spectrometry system. The mass spectrometry system includes an ion source for producing ions, an ion optics system downstream from the ion source for selecting and directing ions, and a detector down stream from the ion optics system for detecting the ions selected and directed by the ion optics system. The ion optics system includes one or more ion extraction pulsers.

Abstract: A tandem mass spectrometer operable to determine properties of chemical and biochemical compounds (analytes) comprises an ion source, a monopole ion processing cell positioned to receive primary ions from the ion source and a mass analyzer positioned to receive secondary ions output from the monopole ion processing cell. The monopole ion processing cell comprises an elongate inner electrode and an elongate outer electrode radially offset from and partially surrounding the inner electrode. In one embodiment, the elongate inner and outer electrodes of monopole ion processing cell are segmented, and at least one of the outer electrode segments defines an axial slot through which the secondary ions are radially output to the mass analyzer.

Abstract: A method and apparatus for processing ions in mass spectrometry is provided. The apparatus includes an ion processing cell having segmented multipole rods and a means for admitting reactive reagent ions to the cell. Provision for timed sequence control of RF and DC voltages to the segmented multipole rods is included. Processing includes trapping analyte ions and subjecting them to selected reactions with reactive reagent ions and/or physical manipulation of the ions by changing the characteristics of the electric field and/or creating discrete regions in the field.

Abstract: A mass spectrometer sample input interface comprises a desolvation apparatus defining a desolvation pathway along which a desolvation gas flows, in a direction from upstream to downstream, the desolvation pathway having a desolvation pathway portion; and an ion pathway apparatus for defining an ion pathway for analyte solution droplets to follow, the ion pathway leading into the mass spectrometer, the ion pathway including an ion pathway portion that follows the desolvation pathway portion.

Abstract: The gain of the ion detector of a mass spectrometer is calibrated by using the ion detector to measure a ratio of the abundances of at least two ion species having a known abundance ratio. The gain of the ion detector is changed until the measured abundance ratio matches the known abundance ratio.

Abstract: An electric field source for a mass spectrometer and a mass spectrometer are described.

Abstract: The invention provides a mass spectrometry system, including a microfluidic chip for electrospray ionization having an analyte channel and a gas assist channel that define a spray tip and a detector downstream from the microfluidic chip for detecting ions. The invention also provides a micro fluidic chip for electrospray ionization including a substrate having an analyte channel, a gas channel and an analyte channel wherein the gas channel and analyte channel exit at the first end to define the electrospray tip. Methods of using the system and apparatus are also disclosed.

Abstract: The invention provides an apparatus for combining ions and charged particles. In general, the apparatus contains: a) a multipole device having an ion exit end; b) a mass analyzer; and c) a source of charged particles. The apparatus is configured so that charged particles produced by the source of charged particles pass through the mass analyzer and into the multipole device via the ion exit end of the multipole device.

Abstract: A multi-channel high field asymmetric waveform ion mobility spectrometer (FAIMS) is provided. The apparatus provides for substantially simultaneous FAIMS analysis of plurality of ions from a single sample. The apparatus has a analyzer region comprising a hollow electrode, a plurality of plate electrodes positioned parallel to and distanced from the hollow electrode, a contact for applying an high voltage asymmetric waveform to the hollow electrode and a plurality of contacts for applying a compensation voltage to the plurality of plate electrodes. A method for substantially simultaneous FAIMS analysis of plurality of ions from a single sample is also provided.