Patents by Inventor Gan-Xin Yan

Gan-Xin Yan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for screening compounds for proarrhythmic risk and antiarrhythmic efficacy
    Patent number: 7396524
    Abstract: Methods for screening compounds for their potential to induce or inhibit a cardiac arrhythmia are disclosed. The methods comprise determining the ratio of the time constant (?) of ICa,L recovery in tissue expressing the L-type calcium channel or any subunit or combination thereof of the L-type calcium channel treated with a test compound to the ventricular repolarization time of cardiac tissue treated with a test compound. The methods further comprise determining an arrhythmic risk score for a specified dose of a test compound.
    Type: Grant
    Filed: August 2, 2005
    Date of Patent: July 8, 2008
    Assignee: Main Line Health Heart Center
    Inventor: Gan-Xin Yan
  • Methods for screening compounds for proarrhythmic risk and antiarrhythmic efficacy
    Publication number: 20070031817
    Abstract: Methods for screening compounds for their potential to induce or inhibit a cardiac arrhythmia are disclosed. The methods comprise determining the ratio of the time constant (?) of ICa,L recovery in tissue expressing the L-type calcium channel or any subunit or combination thereof of the L-type calcium channel treated with a test compound to the ventricular repolarization time of cardiac tissue treated with a test compound. The methods further comprise determining an arrhythmic risk score for a specified dose of a test compound.
    Type: Application
    Filed: August 2, 2005
    Publication date: February 8, 2007
    Inventor: Gan-Xin Yan