Abstract: The present invention relates to compounds that are Nrf2 activators. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with Nrf2 activation.

Abstract: A centrifugal filter unit for an apparatus for use in the treatment of a substrate with a treatment formulation is provided. The centrifugal filter unit includes a) a housing having an outlet; b) an inlet; c) a filter rotatably mounted in the housing and having a side wall with perforations that allow liquid to pass through but prevent solid material from passing through; d) an aperture; and e) a drive for rotating the filter. A portion of the centrifugal filter unit in the filter chamber is removable and, when removed from the centrifugal filter unit following operation, takes with it at least a portion of the solid material prevented from passing through the perforations. The centrifugal filter unit is arranged such that the feed is drawn into the filter from the inlet through the aperture and the liquid is expelled through the perforations to the outlet and the solid material is retained in the filter. The removable portion is shaped to scrape against the side wall during removal.

Abstract: An apparatus, method and kit for use in the treatment of substrates with a solid particulate material, said apparatus comprising a housing having mounted therein a rotatably mounted drum having an inner surface and an end wall and access means for introducing said substrates into said drum, the drum preferably having and elongate protrusion (1) located on said inner surface of said drum, wherein •(a) said drum comprises storage means for storage of said solid particulate material; and •(b) said drum comprises a first collecting flow path to facilitate flow of said solid particulate material from the interior of said drum to said storage means when said drum rotates in a first collecting direction, characterised in that said drum comprises a second collecting flow path to facilitate flow of said solid particulate material from the interior of said drum to said storage means when said drum rotates in a second collecting direction, wherein said second collecting direction is in the opposite rotational direction

Abstract: An apparatus for use in the treatment of substrates with a solid particulate material, said apparatus comprising: (a) a housing having mounted therein a rotatably mounted drum (8) having an inner surface and an end wall; and (b) access means for introducing said substrates into said drum, wherein said drum comprises storage means (2) for storage of said solid particulate material and a plurality of flow paths to facilitate flow of said solid particulate material between said storage means and the interior of said drum (8), characterised in that: said drum (8) comprises a dispensing flow path (5) to facilitate flow of said solid particulate material from said storage means (2) to the interior of said drum (8), and a collecting flow path (6) to facilitate flow of said particulate material from the interior of said drum (8) to said storage means (2), wherein said dispensing flow path (5) and said collecting flow path (6) are different flow paths.

Abstract: A method of treating aqueous, preferably concentrated, waste streams with a unique combination of steps in a way that is easily scalable and able to be used with batch or continuous flows. The method comprises at least the following steps: Adding at least one precipitating agent to the waste water to produce precipitated solids; and removing the precipitated solids from the waste water using a forward flushable membrane to remove the precipitate solids.

Abstract: An apparatus for use in tie treatment of substrates with a solid particulate material, said apparatus comprising a housing having mounted therein a rotatably mounted drum having an inner surface and an end wall, and access means for introducing said substrates into said drum, wherein (a) said drum comprises storage means for storage of said sold particulate material; (b) said drum has at least one elongate protrusion located on said inner surface of said drum wherein the elongate protrusion extends in a direction away from said end wall, wherein said elongate protrusion has an end proximal to the end wall and an end distal to the end wall; (c) the or each elongate protrusion comprises a collecting aperture and a collecting flow path to facilitate flow of said solid particulate material from the interior of said drum to said storage means, wherein said collecting aperture defines the start of a collecting flow path, and wherein the same elongate protrusion further comprises a dispensing aperture and a dispensi

Abstract: This invention relates to a filter which is especially for filtering microfibres which can, for example, originate from the washing of textiles. The filter is rotatable around an axis of rotation. The filter provides good filtering efficiency and improved resistance to blocking.

Abstract: A baffle for use with a treatment machine wherein the treatment machine is configured to treat substrates in the presence of solid particles and wherein the treatment machine comprises a drum and a door for loading a substrate into the drum. The baffle comprises a tub connector portion connecting the baffle to a tub of the treatment machine. The baffle also comprises a door contacting portion for contacting the door of the treatment machine when in use and the door is in a closed configuration. The baffle also comprises a barrier extending between the tub connector portion and the door contacting portion; and wherein the barrier is inclined so that when in use, solid particles deposited on the barrier are diverted into the drum of the treatment machine. There is also provided a treatment machine comprising the baffle and a method of treating a substrate in said treatment machine.

Abstract: Aspects relate to a drum (10) for rotatably mounting in an apparatus for use in the treatment of substrates with a solid particulate material; a method of treating a substrate comprising agitating the substrate in a drum (10); and a kit for converting an apparatus to comprise the drum (10).

Abstract: Semen and sperm cell processing and preservation systems, and methods of producing a mammal and methods of producing mammalian embryos are disclosed. The present invention is directed to sperm cell preservation, fertilization, and insemination, maintaining or enhancing sperm quality and addressing one or more sperm cell characteristics, such as viability, motility, functionality, fertilization rates, and pregnancy rates. Further, sperm cell characteristics may be addressed within the context of various collection, handling, separation, storage, transportation, usage, fertilization, or insemination techniques.

Abstract: Semen and sperm cell processing and preservation systems, and methods of producing a mammal and methods of producing mammalian embryos are disclosed. The present invention is directed to sperm cell preservation, fertilization, and insemination, maintaining or enhancing sperm quality and addressing one or more sperm cell characteristics, such as viability, motility, functionality, fertilization rates, and pregnancy rates. Further, sperm cell characteristics may be addressed within the context of various collection, handling, separation, storage, transportation, usage, fertilization, or insemination techniques.

Abstract: A method of treating aqueous, preferably concentrated, waste streams with a unique combination of steps in a way that is easily scalable and able to be used with batch or continuous flows. The method comprises at least the following steps: Adding at least one precipitating agent to the waste water to produce precipitated solids; and removing the precipitated solids from the waste water using a forward flushable membrane to remove the precipitate solids.

Abstract: Aspects relate to a drum (10) for rotatably mounting in an apparatus for use in the treatment of substrates with a solid particulate material; a method of treating a substrate comprising agitating the substrate in a drum (10); and a kit for converting an apparatus to comprise the drum (10).

Abstract: An apparatus, method and kit for use in the treatment of substrates with a solid particulate material, said apparatus comprising a housing having mounted therein a rotatably mounted drum having an inner surface and an end wall and access means for introducing said substrates into said drum, the drum preferably having and elongate protrusion (1) located on said inner surface of said drum, wherein ? (a) said drum comprises storage means for storage of said solid particulate material; and ? (b) said drum comprises a first collecting flow path to facilitate flow of said solid particulate material from the interior of said drum to said storage means when said drum rotates in a first collecting direction, characterised in that said drum comprises a second collecting flow path to facilitate flow of said solid particulate material from the interior of said drum to said storage means when said drum rotates in a second collecting direction, wherein said second collecting direction is in the opposite rotational directio

Abstract: An apparatus for use in the treatment of substrates with a solid particulate material, said apparatus comprising: (a) a housing having mounted therein a rotatably mounted drum (8) having an inner surface and an end wall; and (b) access means for introducing said substrates into said drum, wherein said drum comprises storage means (2) for storage of said solid particulate material and a plurality of flow paths to facilitate flow of said solid particulate material between said storage means and the interior of said drum (8), characterised in that: said drum (8) comprises a dispensing flow path (5) to facilitate flow of said solid particulate material from said storage means (2) to the interior of said drum (8), and a collecting flow path (6) to facilitate flow of said particulate material from the interior of said drum (8) to said storage means (2), wherein said dispensing flow path (5) and said collecting flow path (6) are different flow paths.

Abstract: A centrifugal filter unit for an apparatus, wherein the apparatus is for use in the treatment of a substrate with a treatment formulation, the centrifugal filter unit comprising; a) a housing having an outlet configured to allow a filtrate to exit the centrifugal filter unit; b) a filter rotatably mounted in the housing, wherein the filter comprises a first end proximate a first end of the housing, a second end proximate a second end of the housing and a side wall connecting the first end of the filter and the second end of the filter, wherein the first end, second end and side wall of the filter define a filter chamber, and wherein the side wall comprises perforations configured to allow liquid to pass throughout to prevent solid material from passing through; c) a lid configured to substantially seal the first end of the housing; d) an inlet configured to allow a feed to enter the filter chamber; e) a cap at the first end of the filter, wherein the cap comprises an aperture that cooperates with the inlet to

Abstract: The invention provides an apparatus and method for use in the drying of substrates using a solid particulate material, the apparatus comprising: (a) housing means having mounted therein a rotatably mounted cylindrical drum; (b) access means; and (c) at least one collection means, wherein the rotatably mounted cylindrical drum additionally comprises capturing and transferring means, adapted to facilitate collection of the solid particulate material and transfer of the material to the at least one collection means. The invention also provides a method for drying a wet substrate, the method comprising treating the substrate with a solid particulate material at ambient or elevated temperature, the treatment being carried out using the apparatus of the invention. The apparatus and method find particular application in the drying of wet textile fabrics.

Abstract: An aircraft passenger seat comprises a seat back and a seat pan, the seat pan being pivotally connected at or around a forward end thereof to a seat frame at a first pivot point, and at or around a rearward end thereof to a lower end of the seat back at a second pivot point. The seat back has an extension extending beyond the second pivot point and engaging a guide track in or connected to the seat frame, and a reclining actuator for driving the extension along the guide track so as to adjust the reclining of the seat.

Abstract: An aircraft passenger seat comprises a seat back and a seat pan, the seat pan being pivotally connected at or around a forward end thereof to a seat frame at a first pivot point, and at or around a rearward end thereof to a lower end of the seat back at a second pivot point. The seat back has an extension extending beyond the second pivot point and engaging a guide track in or connected to the seat frame, and a reclining actuator for driving the extension along the guide track so as to adjust the reclining of the seat.