Abstract: Genetically modified mice characterized by one or more symptoms or signs associated with expression of human APOE4p and mouse Trem2p and relevant to non-familial late-onset Alzheimer's disease are provided wherein the genome of the mouse includes: 1) a DNA sequence encoding a human APOE4 protein (APOE4p) operably linked to a promoter; and 2) a DNA sequence encoding a mouse Trem2 protein having a mutation p,R47H (Trem2p) operably linked to a promoter, such that the mouse expresses human APOE4p and mouse Trem2p. Methods ace provided for screening for a compound for use in the treatment of Alzheimer's disease using such genetically modified mice.

Abstract: The present disclosure provides immunodeficient mouse models that comprise a nucleic acid encoding a human or humanized amyloid precursor protein (APP) and, in some models, further comprise a nucleic acid encoding a mutated human presenilin 1 protein (PSEN1). These mouse models are useful, for example, for Alzheimer's disease studies.

Abstract: Collaborating on documents by e-mail may be streamlined into a unified process. In one example, a user creates a document in an online document service, and sends the document to collaborators by mailing a link to the document. The document may have permissions set so that the creator of the document, and any user on the e-mail distribution list, can read and edit the document. When a user receives the e-mail, that user may open and edit the document. Upon closing the editing application, the user may be presented with an appropriate interface to create a reply e-mail.

Abstract: The present disclosure provides a genetically modified mouse comprising a genomic nucleic acid encoding human APOE4, a genomic nucleic acid encoding mouse TREM2 modified to include a R47H substitution, and at least one genomic modification selected from the group consisting of: (a) a genomic nucleic acid encoding mouse ABCA7 modified to include an A 1541 G substitution; (b) a genomic nucleic acid encoding mouse APP modified to include G601R, F606Y, and R609H substitutions; (c) a genomic nucleic acid encoding mouse PLCG2 modified to include a M28L substitution; (d) a genomic nucleic acid encoding mouse MTHFR modified to include a A262V substitution; (e) an inactivated Ceacam1 allele; and (f) an inactivated Il1rap allele. Methods of producing the genetically modified mouse and methods of using the genetically modified mouse are also provided.

Abstract: Genetically modified mice characterized by one or more symptoms or signs associated with expression of human APOE4p and mouse Trem2p and relevant to non-familial late-onset Alzheimer's disease are provided wherein the genome of the mouse includes: 1) a DNA sequence encoding a human APOE4 protein (APOE4p) operably linked to a promoter; and 2) a DNA sequence encoding a mouse Trem2 protein having a mutation p,R47H (Trem2p) operably linked to a promoter, such that the mouse expresses human APOE4p and mouse Trem2p. Methods ace provided for screening for a compound for use in the treatment of Alzheimer's disease using such genetically modified mice.

Abstract: Collaborating on documents by e-mail may be streamlined into a unified process. In one example, a user creates a document in an online document service, and sends the document to collaborators by mailing a link to the document. The document may have permissions set so that the creator of the document, and any user on the e-mail distribution list, can read and edit the document. When a user receives the e-mail, that user may open and edit the document. Upon closing the editing application, the user may be presented with an appropriate interface to create a reply e-mail.

Abstract: Embodiments are provided for utilizing server pre-processing to deploy static renditions of electronic documents in a computer network. An electronic document may be published from a client computer to a first server computer in the computer network. During publication, the first server computer may create a static rendition of the electronic document and a viewing application for viewing the static rendition of the electronic document on the client computer. The first server computer may store the static rendition of the electronic document and the viewing application on a second server computer for delivery to the client computer. Other embodiments may also include receiving, at the first server computer, a request to make revisions to the electronic document and sending a dynamic version of the electronic document from the first server computer to the client for making the revisions to the electronic document.

Abstract: Collaborating on documents by e-mail may be streamlined into a unified process. In one example, a user creates a document in an online document service, and sends the document to collaborators by mailing a link to the document. The document may have permissions set so that the creator of the document, and any user on the e-mail distribution list, can read and edit the document. When a user receives the e-mail, that user may open and edit the document. Upon closing the editing application, the user may be presented with an appropriate interface to create a reply e-mail.

Abstract: Embodiments are provided for utilizing server pre-processing to deploy static renditions of electronic documents in a computer network. An electronic document may be published from a client computer to a first server computer in the computer network. During publication, the first server computer may create a static rendition of the electronic document and a viewing application for viewing the static rendition of the electronic document on the client computer. The first server computer may store the static rendition of the electronic document and the viewing application on a second server computer for delivery to the client computer. Other embodiments may also include receiving, at the first server computer, a request to make revisions to the electronic document and sending a dynamic version of the electronic document from the first server computer to the client for making the revisions to the electronic document.

Abstract: Techniques to automatically syndicate content over a network are described. An apparatus may comprise a client computer having a processing system with a processor and computer-readable medium. The computer readable medium may store program instructions for a syndication manager component communicatively coupled to a content producing component arranged to be executed by the processor. The syndication manager component may be operative to receive syndication content from the content producing component, and provide a syndication dialog through the content producing component to syndicate the syndication content using a content delivery platform. The syndication manager component may also syndicate the syndication content to form a syndication resource accessible from the content delivery platform over a network using a syndication referent. Other embodiments are described and claimed.

Abstract: Techniques to automatically syndicate content over a network are described. An apparatus may comprise a client computer having a processing system with a processor and computer-readable medium. The computer readable medium may store program instructions for a syndication manager component communicatively coupled to a content producing component arranged to be executed by the processor. The syndication manager component may be operative to receive syndication content from the content producing component, and provide a syndication dialog through the content producing component to syndicate the syndication content using a content delivery platform. The syndication manager component may also syndicate the syndication content to form a syndication resource accessible from the content delivery platform over a network using a syndication referent. Other embodiments are described and claimed.

Abstract: Collaborating on documents by e-mail may be streamlined into a unified process. In one example, a user creates a document in an online document service, and sends the document to collaborators by mailing a link to the document. The document may have permissions set so that the creator of the document, and any user on the e-mail distribution list, can read and edit the document. When a user receives the e-mail, that user may open and edit the document. Upon closing the editing application, the user may be presented with an appropriate interface to create a reply e-mail.

Abstract: Techniques to automatically syndicate content over a network are described. An apparatus may comprise a client computer having a processing system with a processor and computer-readable medium. The computer readable medium may store program instructions for a syndication manager component communicatively coupled to a content producing component arranged to be executed by the processor. The syndication manager component may be operative to receive syndication content from the content producing component, and provide a syndication dialog through the content producing component to syndicate the syndication content using a content delivery platform. The syndication manager component may also syndicate the syndication content to form a syndication resource accessible from the content delivery platform over a network using a syndication referent. Other embodiments are described and claimed.

Abstract: Collaborating on documents by e-mail may be streamlined into a unified process. In one example, a user creates a document in an online document service, and sends the document to collaborators by mailing a link to the document. The document may have permissions set so that the creator of the document, and any user on the e-mail distribution list, can read and edit the document. When a user receives the e-mail, that user may open and edit the document. Upon closing the editing application, the user may be presented with an appropriate interface to create a reply e-mail.

Abstract: Techniques to automatically syndicate content over a network are described. An apparatus may comprise a client computer having a processing system with a processor and computer-readable medium. The computer readable medium may store program instructions for a syndication manager component communicatively coupled to a content producing component arranged to be executed by the processor. The syndication manager component may be operative to receive syndication content from the content producing component, and provide a syndication dialog through the content producing component to syndicate the syndication content using a content delivery platform. The syndication manager component may also syndicate the syndication content to form a syndication resource accessible from the content delivery platform over a network using a syndication referent. Other embodiments are described and claimed.

Abstract: Techniques to automatically syndicate content over a network are described. An apparatus may comprise a client computer having a processing system with a processor and computer-readable medium. The computer readable medium may store program instructions for a syndication manager component communicatively coupled to a content producing component arranged to be executed by the processor. The syndication manager component may be operative to receive syndication content from the content producing component, and provide a syndication dialog through the content producing component to syndicate the syndication content using a content delivery platform. The syndication manager component may also syndicate the syndication content to form a syndication resource accessible from the content delivery platform over a network using a syndication referent. Other embodiments are described and claimed.

Abstract: Systems and methods for creating a secure process on a web server can include creating an application manager process, and creating an application host process, the application host process being created under control of the application manager process. Example methods can also include restricting attributes of the application host process, and assigning a unique logon identifier to the application host process so that the application host process can only communicate with the application manager process.

Abstract: An integrated circuit assembly having monitoring circuitry for observing the internal signals of the system so that its properties are captured. The system properties are manipulated so that they can be used as a pseudo random number and or as the basis number for an encryption key. The monitoring circuitry having: manipulation circuitry to transform monitored data and combine it with previously manipulated values; and registers to store previously manipulated values; and counters to count events; and condition detection circuitry for detecting when a signal is at a specific value or range of values. Optionally the monitoring circuitry which has the functionality for capturing system properties may be combined with other monitoring circuitry, which has the functionality required by a debug support circuit. The monitoring circuitry avoids replication of resources by sharing parts of specific monitoring circuits like counters.

Abstract: A media processing framework includes multiple media processing paths. At least one of the media processing paths includes a media processing pipeline which is in-process with respect to an application which interacts with the media processing pipeline. At least one other of the media processing paths includes a media processing pipeline which is out-of-process with respect to the application. The application can specify a custom plug-in presenter module to be set in either the in-process media processing pipeline or the out-of-process media processing pipeline. The application need not be “aware” of the pipeline that is being used, whether the pipeline is in-process or out-of-process, or the security level that is applied to the media processing pipeline. Both the in-process and the out-of-process media processing pipelines can supply media information to a presentation processor, such as a compositing engine.

Abstract: Techniques to automatically syndicate content over a network are described. An apparatus may comprise a client computer having a processing system with a processor and computer-readable medium. The computer readable medium may store program instructions for a syndication manager component communicatively coupled to a content producing component arranged to be executed by the processor. The syndication manager component may be operative to receive syndication content from the content producing component, and provide a syndication dialog through the content producing component to syndicate the syndication content using a content delivery platform. The syndication manager component may also syndicate the syndication content to form a syndication resource accessible from the content delivery platform over a network using a syndication referent. Other embodiments are described and claimed.