Abstract: A needle actuator assembly for a drug delivery system includes a housing, a needle having retracted and extended positions, a needle actuator body received within the housing and configured to move from a pre-use position where the needle is in the retracted position to a use position where the needle is in the extended position and to a post-use position where the needle is in the retracted position, with the needle actuator having a button contact surface, and an actuator button received by the housing.

Abstract: A drug delivery system for injecting a medicament includes a housing, a container configured to receive a medicament including a stopper configured to move within the container and a closure, a needle in fluid communication with the container, a spacer configured to be engaged with the stopper, a first plunger, a first spring configured to bias the first plunger in an axial direction, second plunger disposed about the first plunger, a second spring configured to bias the second plunger in an axial direction. The first plunger is configured to move the spacer and the container relative to the housing via the first spring to establish fluid communication between the container and the patient needle, and the second plunger is configured to move the spacer and the stopper relative to the container via the second spring.

Abstract: Some headphone systems include two ear cups, a headband assembly, an interface system and a control system. Each ear cup may include an ear cup enclosure, an ear pad assembly, a speaker system and a hinge assembly. The hinge assembly may be disposed within the ear cup enclosure such that it is not visible from outside the ear cup. The headband assembly may connect with each of the ear cups via the hinge assembly. The interface system may include at least one interface and a plurality of input source buttons disposed on at least one of the ear cups. Each of the input source buttons may be configured for selecting a source of audio data received via the at least one interface. The control system may be configured for controlling the speaker system to reproduce audio data received via the interface and selected by one of the input source buttons.

Abstract: A cable gland sealing member comprising: a sleeve (19) arranged to be slidably received within a passage (9) defined in a body (5) of a cable gland, the sleeve (19) arranged to receive a settable sealing material for forming a seal to a cable passing through the sleeve, wherein the sleeve (19) is defined by an annular side wall extending along an axial length; wherein an outer surface (71) of the sleeve (19) includes a tapered portion (95) such that the external diameter of the sleeve (19) widens in the tapered portion (95); and wherein the outer surface (71) of the sleeve (19) is arranged to form a seal with the cable gland body (5). A cable gland is also disclosed using such a sealing member.

Abstract: This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.

Abstract: Medical tubes and methods of manufacturing medical tubes are disclosed, such as in positive airway pressure (PAP), respirator, anaesthesia, ventilator, and insufflation systems. The tube may be a composite structure made of two or more distinct components spirally wound to form an elongate tube. One of the components may be a spirally wound elongate hollow body, and the other component an elongate structural component spirally wound between turns of the spirally wound hollow body. Alternatively, the tube need not be made from distinct components. For instance, an elongate hollow body formed (e.g., extruded) from a single material may be spirally wound to form an elongate tube. The elongate hollow body itself may in transverse cross-section have a thin wall portion and a relatively thicker or more rigid reinforcement portion. The tubes can be incorporated into a variety of medical circuits or have other medical uses.

Abstract: A needle actuator assembly for a drug delivery system includes a housing, a needle having retracted and extended positions, a needle actuator body received within the housing and configured to move from a pre-use position where the needle is in the retracted position to a use position where the needle is in the extended position and to a post-use position where the needle is in the retracted position, with the needle actuator having a button contact surface, and an actuator button received by the housing.

Abstract: A drug delivery system for injecting a medicament includes a housing, a container configured to receive a medicament including a stopper configured to move within the container and a closure, a needle in fluid communication with the container, a spacer configured to be engaged with the stopper, a first plunger, a first spring configured to bias the first plunger in an axial direction, second plunger disposed about the first plunger, a second spring configured to bias the second plunger in an axial direction. The first plunger is configured to move the spacer and the container relative to the housing via the first spring to establish fluid communication between the container and the patient needle, and the second plunger is configured to move the spacer and the stopper relative to the container via the second spring.

Abstract: A modular electronics assembly comprising: removable electronic modules comprising a module housing containing electronic circuitry and bearing a module electrical connector coupled to the electronic circuitry each removable electronic module having a first alignment formation; an enclosure having an interior dimensioned to contain the removable electronic modules therein, the enclosure including, one or more enclosure electrical connectors corresponding to one or more of the module electrical connectors for establishing a connection, guide members extending into the interior of the enclosure for guiding respective ones of the module housings toward the enclosure electrical connectors; second alignment formations each arranged to cooperate with a respective first alignment formation of the removable electronic modules for aligning module electrical connectors with enclosure electrical connectors to thereby establish connection; wherein the first alignment formations are positioned on the module housings to re

Abstract: A drug delivery system for injecting a medicament is provided. The system includes a container configured to receive a medicament; a drive assembly which, upon actuation, is configured to expel the medicament from the container; a needle for injecting the medicament to a patient; a fluid path assembly comprising a tube in fluid communication with the container and the needle for conducting fluid from the container to the needle; and a tube crimping arrangement configured to engage the tube to block fluid flow through the tube. The drive assembly causes the tube crimping arrangement to engage the tube after a dose of the medicament has been delivered to the patient through the needle.

Abstract: The present invention provides an antimicrobial composition comprising at least one garlic extract and one or more of a bioflavonoid and/or an organic acid as well as the use of the same for treating or preventing bacterial, fungal or parasitic infections.

Abstract: An apparatus comprises memory access circuitry to access a memory system; a plurality of memory mapped registers, including at least an insert register and a producer pointer register; and control circuitry to perform an insert operation in response to receipt of an insert request from a requester device sharing access to the memory system. The insert request specifies an address mapped to the insert register and an indication of a payload. The insert operation includes controlling the memory access circuitry to write the payload to a location in the memory system selected based on a producer pointer value stored in the producer pointer register, and updating the producer pointer register to increment the producer pointer value.

Abstract: A method, system, and computer program product for automated testing of Internet of Things devices are provided. The method generates a device table for a set of devices. The device table includes a set of inputs and a set of controllable outputs for each device. A set of input signals are detected for a device for a subset of inputs associated with the device. The set of input signals are detected from one or more controllable outputs of a subset of devices. The device table is modified based on the set of input signals and the one or more controllable outputs to generate an association table representing a relation of the subset of inputs with the one or more controllable outputs. The method detects a fault in one or more device of the set of devices based on a test input signal and the association table.

Abstract: Provided are techniques for generating highlight queries. Data is analyzed using one or more schemas to identify patterns and frequencies of the patterns in the data. The patterns and the frequencies of the patterns are stored in a global patterns structure. A graph is analyzed to identify one or more of the patterns in the global patterns structure that are present in the graph and in which frequencies. The identified one or more of the patterns in the global patterns structure that are present in the graph are added to a per-user patterns structure with the frequencies of those patterns. The patterns in the per-user patterns structure are scored. A subset of the patterns in the per-user patterns structure that have scores above a threshold are selected as highlight queries. The selected subset of the patterns are executed as highlight queries to generate results, and the results are returned.

Abstract: The present invention provides an adhesive tamper evident vehicle registration label or an adhesive tamper evident label support. The adhesive tamper evident vehicle registration label comprises a frangible layer of a label comprising an upper surface and an opposed lower surface, in which the frangible layer comprises a plurality of layer portions located adjacent to each other and separable from each other by at least one line of weakness extending between the upper and lower surfaces thereof. The adhesive tamper evident label support comprises a frangible support layer for receiving a label, the frangible support layer comprising an upper surface for receiving a label thereon, and an opposed lower surface, in which the frangible support layer comprises a plurality of support layer portions located adjacent to each other and separable from each other by at least one opening and/or line of weakness extending between the upper and lower surfaces of the support layer.

Abstract: Some headphone systems include two ear cups, a headband assembly, an interface system and a control system. Each ear cup may include an ear cup enclosure, an ear pad assembly, a speaker system and a hinge assembly. The hinge assembly may be disposed within the ear cup enclosure such that it is not visible from outside the ear cup. The headband assembly may connect with each of the ear cups via the hinge assembly. The interface system may include at least one interface and a plurality of input source buttons disposed on at least one of the ear cups. Each of the input source buttons may be configured for selecting a source of audio data received via the at least one interface. The control system may be configured for controlling the speaker system to reproduce audio data received via the interface and selected by one of the input source buttons.

Abstract: A drive assembly for a drug delivery system including a plunger member configured to engage and move a stopper within a container, a biasing member configured to move the plunger member, and an adjustable spacer assembly positioned between the plunger member and the stopper. The spacer assembly includes a spacer element attached to the stopper and at least one shim or includes a spacer element and a holder to which the spacer element is attached. The holder may be attached to the stopper and the spacer element may be attached to the holder by a threaded engagement. Also, a drug delivery system for injecting a medicament, the system including a container configured to receive a medicament, the container comprising a stopper configured to move within the container and a closure, a drive assembly as described above, and a needle actuator assembly.