Patents by Inventor Gareth R. Tibbs

Gareth R. Tibbs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted alkylphenols as HCN1 antagonists
    Patent number: 11684590
    Abstract: Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: June 27, 2023
    Assignee: Cornell University
    Inventors: Gareth R. Tibbs, Peter A. Goldstein, Anthony A. Sauve, Rajendra Uprety, James David Warren, Jr., Rebecca L. Joyce, Dipti N. Barman
  • SUBSTITUTED ALKYLPHENOLS AS HCN1 ANTAGONISTS
    Publication number: 20210267909
    Abstract: Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.
    Type: Application
    Filed: June 27, 2019
    Publication date: September 2, 2021
    Applicant: Cornell University
    Inventors: Gareth R. Tibbs, Peter A. Goldstein, Anthony A. Sauve, Rajendra Uprety, James David Warren, Rebecca L. Joyce, Dipti N. Barman
  • COMPOSITIONS AND METHODS OF TREATING CHRONIC PAIN BY ADMINISTERING PROPOFOL DERIVATIVES
    Publication number: 20190358175
    Abstract: Compositions and methods for managing or treating chronic pain are provided. More particularly, methods are provided for managing or treating chronic pain by administering to a patient in need thereof an effective amount of propofol or a propofol derivative having limited anesthetic properties. Methods of modulating HCN channel gating are also provided. Pharmaceutically acceptable compositions for, e.g., modulating HCN channel gating are further provided.
    Type: Application
    Filed: June 28, 2019
    Publication date: November 28, 2019
    Inventors: Gareth R. Tibbs, Pamela Flood, Peter Goldstein
  • COMPOSITIONS AND METHODS OF TREATING CHRONIC PAIN BY ADMINISTERING PROPOFOL DERIVATIVES
    Publication number: 20130005718
    Abstract: Compositions and methods for managing or treating chronic pain are provided. More particularly, methods are provided for managing or treating chronic pain by administering to a patient in need thereof an effective amount of propofol or a propofol derivative having limited anesthetic properties. Methods of modulating HCN channel gating are also provided. Pharmaceutically acceptable compositions for, e.g., modulating HCN channel gating are further provided.
    Type: Application
    Filed: August 10, 2010
    Publication date: January 3, 2013
    Inventors: Gareth R. Tibbs, Pamela Flood, Peter Goldstein