Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: A circuit connector for a humidification system, the system comprising a base unit configured to be engaged by a humidification chamber. The circuit connector comprises an inlet to fluidly connect to an outlet of the humidification chamber to receive humidified gases therefrom, an outlet to sealably connect to or integral with a conduit for directing the humidified gases to a user, and an electrical terminal for electrically coupling the circuit connector to an electrical terminal associated with the base unit. The circuit connector may be releasably and lockably connectable to the outlet of the humidification chamber and/or orientation features may control orientation of component parts of the system as they are assembled.

Abstract: An optical device includes a first electrode and a medium that includes ferroelectric liquid crystals and chiral dopants. The medium is located adjacent to the first electrode. The optical device may also include a second electrode distinct and separate from the first electrode. The optical device may be used as an optical dimming device, controlling an amount light passing through the optical device based on a voltage gradient provided to the optical device.

Abstract: An optical device includes a first set of one or more electrodes, a second set of one or more electrodes distinct and separate from the first set of one or more electrodes, and a solution containing transparent metal ions in a liquid or gel electrolyte. The solution is located between the first set of one or more electrodes and the second set of one or more electrodes. The optical device may operate as an optical dimming device, which may be used in head-mounted display devices or as dimmable windows or shutters.

Abstract: A method for determining the susceptibility of a patient suffering from proliferative disease to treatment using an agent targeting a cell pathway or components thereof comprises an immune-checkpoint comprising components of the PD1/PD-L1 pathway, an agent targeting DDR signalling pathway comprising PARP inhibitors, DDR inhibitors and cell cycle checkpoint inhibitors, or a combination of thereof. The method comprises determining tumour type, determining expression levels of PD-L1, determining tumour mutational burden, preparing a DNA damage and repair related genes analysis based on the tumour type and PD-L1 expression levels.

Abstract: The field of the invention relates to methods, servers and computer program products for inferring which fare classes are available. There is provided a method of inferring fare class availability for a specific flight or flights by: (a) receiving observable, live bookable prices for that flight(s), in which that price information is not accompanied by complete fare class information for those flight(s); (b) comparing the observable, live bookable prices with a set of prices calculated from stored data, such as valid itinerary data, fare data such as FROP data, and tax/surcharge data; and (c) determining which fare class was used in the observable live bookable price by determining which fare class was used in the calculated price that matches most closely to the observable live bookable price.

Abstract: A material 100 for an anti-theft device is described. The material 100 comprises a binder 102, a first type of particles 104, a second type of particles 106, and graphene layer 114 between the binder and each of the first type of particles 104 and second type of particles 106. The first type of particles 104 are selected from at least one of diamond and cubic boron nitride ‘CBN’, and the second type of hard particles are selected from at least one of a metallic carbide and a ceramic material. The first particles resist a cutting action of a cutting tool and the second particles degrade the cutting tool during the cutting action. The graphene bonds the particles to the binder to prevent the particles being dislodged by a cutting action. The result of the combination of these actions is to delay the time for an operator of a cutting tool to cut through the material 100.

Abstract: The field of the invention relates to methods, servers and computer program products for inferring which fare classes are available. There is provided a method of inferring fare class availability for a specific flight or flights by: (a) receiving observable, live bookable prices for that flight(s), in which that price information is not accompanied by complete fare class information for those flight(s); (b) comparing the observable, live bookable prices with a set of prices calculated from stored data, such as valid itinerary data, fare data such as FROP data, and tax/surcharge data; and (c) determining which fare class was used in the observable live bookable price by determining which fare class was used in the calculated price that matches most closely to the observable live bookable price.

Abstract: The present invention relates to novel probe compounds of formulae I and II defined herein. The present invention also relates to methods of synthesising these novel probe compounds and to their use in assays and screens for determining the binding of a test molecule to the ATP-binding site of a target protein, such as, for example, the Mismatch Repair (MMR) component proteins PMS2 and MLH1, or for determining the location and/or quantity of such target proteins in a biological sample.

Abstract: The invention relates to a nanofibrous material comprising a drug for treating a peripheral nerve injury by delivering the drug locally to a damaged or injured nerve. The drug may be such a Non Steroidal Anti Inflammatory Drug or a PPAR agonist. In particular, the invention relates to a drug eluting nerve wrap or bandage that can be wrapped around an injured peripheral nerve. The invention also relates to a nanofibrous drug delivery system or device for delivering a drug locally to a peripheral nerve, a treatment for a peripheral nerve injury comprising contacting a damaged nerve with the drug eluting nanofibrous material or drug delivery system, kits and methods for making the nanofibrous materials, and uses of the nanofibrous materials.

Abstract: A portable exercise apparatus in the shape of a square having a handle at either side, which handles are arranged rotatable on spindles such that the user can impart movement on said apparatus without changing his/her grip.

Abstract: The present invention relates to a method for diagnosing cancers of the genitourinary tract, as well as methods of treatment of patients diagnosed using the method.

Abstract: A portable exercise apparatus in the shape of a square having a handle at either side, which handles are arranged rotatable on spindles such that the user can impart movement on said apparatus without changing his/her grip.

Abstract: The field of the invention relates to methods, servers and computer program products for providing a set of prices. A computer server receives a request for a price for goods or services, such as airfares, together with parameters defining those goods or services, for example: activity type, such as airfare, hotel booking, train fare; date range; destination; origin; desired weather conditions; star ratings; keywords; any other user defined preference. One or more processors programmed with software then infer, estimate or predict estimated prices from an incomplete historical price dataset by analysing patterns in that dataset and provide the price estimates to an end-user computing device, such as a personal computer, smartphone or tablet.

Abstract: There is provided a combination of agents which allow normal cells to be reversibly arrested in G1 phase thereby shielding them from the toxic effects of cytotoxic agents used to kill cancer cells in cancer treatment.

Abstract: The field of the invention relates to methods, servers and computer program products for providing a set of prices. A computer server receives a request for a price for goods or services, such as airfares, together with parameters defining those goods or services, for example: activity type, such as airfare, hotel booking, train fare; date range; destination; origin; desired weather conditions; star ratings; keywords; any other user defined preference. One or more processors programmed with software then infer, estimate or predict estimated prices from an incomplete historical price dataset by analysing patterns in that dataset and provide the price estimates to an end-user computing device, such as a personal computer, smartphone or tablet.

Abstract: A personalized seating zone system of a vehicle cabin and a method for implementing such. The personalized seating zone system includes at least one personalized seating zone and is configured to collect biometric data corresponding to an occupant of the personalized seating zone system, match the collected biometric data to an identification tag to identify the occupant by comparing the collected biometric data to stored biometric data from an identification database, and load seat system settings for a personalized seating zone within the personalized seating zone system based on the matched identification tag.

Abstract: Apparatus for deployment, recovery and/or storage of a resource comprising a flexible length of equipment capable of being wound on a spool, the apparatus comprising a rigid container shaped and configured to be handled by a specified vehicle type, the container having at least a base and a pair of opposing end walls, and an open side or an opening in a side wall thereof, wherein, on said base between said opposing end walls, there is provided a mounting member on which said spool is or can be mounted for rotation about its longitudinal axis. In an exemplary embodiment, the external dimensions of said container conform to the ISO 668 International Standard, and the equipment comprises a surface-covering track comprised of interconnected panels.

Abstract: A method for determining the susceptibility of a patient suffering from proliferative disease to treatment using an agent which targets a component of the PD1/PD-L1 pathway, said method comprising determining in a tumour sample from said patient at least three biomarkers selected from list including those directly related to the PD-1/PD-L1 pathway as well as other oncogenic biomarkers and the tumour mutational burden, and relating the presence of more than one of said biomarkers as an indicator susceptibility to said agent. Methods for making the determinations and algorithms for dealing with the results are also described and claimed.

Abstract: The field of the invention relates to methods and systems for comparing goods or services from websites, databases or other on-line resources. The field of the invention includes related servers, user terminals and computer program products. There is provided a method of comparing goods and/or services from one or more websites or other on-line resource(s) in which a multi-objective optimization process is used to identify a set of specific goods and/or services that optimally match user-defined and/or user-associated criteria and then that set of specific goods and/or services is displayed on an end-user's computing device to enable the end-user to view that set and optionally purchase one or more items from that set.