Abstract: Systems and methods for generating maps for retail environments and other indoor locations, such as via autonomous or other automatic processes, are described. In some embodiments, the systems and methods access images of a retail environment captured via multiple security cameras placed within the retail environment, and generate a two- or three-dimensional digital, virtual and/or interactive map that depicts a layout of the retail environment based on features extracted from the accessed images. For example, the systems and methods may extract and/or determine walkable paths within the images, and generate a two- or three-dimensional map that is based on placing the walkable paths within the retail environment.

Abstract: Embodiments herein disclose a method for identifying co-evolving sites and and at least one substituent amino acid residue. The method includes obtaining a current state of a protein and an ancestral state of the protein. Further, the method includes determining at least one amino acid substitution along with at least one co-evolving site associated with the protein based on the current state of the protein and the ancestral state of the protein. Further, the method includes assessing the at least one amino acid substitution as a function of a nucleotide substitution in the protein. Further, the method includes assessing at least one co-evolving site substitution based on the at least one assessed amino acid substitution. Further, the method includes identifying the co-evolving sites and at least one substituent amino acid residue.

Abstract: Accordingly, embodiments herein disclose a method for handling an enzyme function through at least one change at multiple sites in an enzyme. The method includes detecting, by an electronic device, one or more functionally linked site pairs from the multiple sites in the enzyme. Further, the method includes determining, by the electronic device, at least one criticality assessment function for the one or more functionally linked site pairs. Further, the method includes prioritizing, by the electronic device, the functionally linked site pairs based on at least one of the criticality assessment function, a functional linkage strength, and a spatial linkage metric. Further, the method includes identifying, by the electronic device, the multiple sites from the prioritized functionally linked site pairs as optimum sites for introducing a change to handle the enzyme function.

Abstract: Provided are methods and devices for mutation prioritization, which are helpful in personalized therapy of a patient. Also, provided are methods and devices for generating a disease knowledgebase. Information present in various categories of knowledge sources with respect to a particular association of <Disease, Gene, Mutation> set may be identified. The identified information is ranked with respect to the disease knowledgebase to find out the most relevant ones for the treatment of a particular Disease/Gene/Mutation of a patient, thereby enabling medical experts to personalize a therapy to be administered to a patient.

Abstract: A method for predicting a change in a functional property of a biomolecule includes obtaining a plurality of biomolecules and mutation data associated with at least one functional property; determining a net change in the at least one functional property based on at least one parameter associated with the mutation data for each biomolecule at a site; encoding a plurality of sequenced features for the mutation data associated with each biomolecule; configuring a prediction model to detect a relationship of the sequence features and the net change in the at least one functional property of the mutation data associated with each biomolecule; and predicting a change in the at least one functional property of a target biomolecule based on the prediction model for the mutation data at a user specified site.

Abstract: A method of predicting an amino acid substitution includes: receiving input of information regarding a structure of an enzyme along with the site of the enzyme in proximity to a bound ligand; identifying a functional atom of a wild type (WT) amino acid at the site of interest and a functional atom of the ligand; confirming properties of the functional atom of the WT amino acid and the functional atom of the ligand; detecting whether an interaction exists between the functional atom of the WT amino acid and the functional atom of the ligand; selecting alternative amino acids according to a result of the detecting of the interaction; determining a score for each of the selected alternative amino acids, respectively; ranking the selected alternative amino acids, based on the scores; and predicting substitutions of alternative amino acids having high rankings from among the selected alternative amino acids.

Abstract: Provided are methods and devices for mutation prioritization, which are helpful in personalized therapy of a patient. Also, provided are methods and devices for generating a disease knowledgebase. Information present in various categories of knowledge sources with respect to a particular association of <Disease, Gene, Mutation> set may be identified. The identified information is ranked with respect to the disease knowledgebase to find out the most relevant ones for the treatment of a particular Disease/Gene/Mutation of a patient, thereby enabling medical experts to personalize a therapy to be administered to a patient.

Abstract: The present invention relates to preservation of cosmetic formulations. More specifically, the present invention relates to a preservative composition for cosmetic formulations comprising thymol, monolaurin and magnolol obtained from supercritical fluid extracts of Magnolia officinalis.

Abstract: The present disclosure relates generally to systems and methods for a mobile advertising and content caching mechanism for mobile devices and a method for using such a mechanism. In one example, the method includes monitoring a mobile device for activity indicating user interest in an advertising area. The method detects an application launch request corresponding to the monitored activity and intercepts the application launch request. The method provides multimedia advertising content to an output component of the mobile device, and launches the application corresponding to the application launch request after the multimedia advertising content has finished playing on the output component.

Abstract: The present invention relates to preservation of cosmetic formulations. More specifically, the present invention relates to a preservative composition for cosmetic formulations comprising thymol, monolaurin and magnolol obtained from supercritical fluid extracts of Magnolia officinalis.

Abstract: The present invention relates to preservation of cosmetic formulations. More specifically, the present invention relates to a preservative composition for cosmetic formulations comprising thymol, monolaurin and magnolol obtained from supercritical fluid extracts of Magnolia officinalis.

Abstract: A system for selecting customized content for a user device is provided. The system includes a processor and an information extractor that, when executed by the processor, is configured to obtain at least one keyword from analyzing data entered into the user device. The system includes a behavioral engine that, when executed by the processor, is configured to obtain at least one keyword from analyzing a behavior of a user of the user device. The system also includes a keyword manager that, when executed by the processor, is configured to receive at least two keywords from the information extractor and/or the behavioral engine and to analyze the at least two keywords to obtain a prioritized list of keywords and to provide the prioritized list of keywords to a component that is configured to select customized content for the user device based on the prioritized list of keywords.

Abstract: Disclosed is a novel method for preserving cosmetic/personal care formulations through a two component preservative system, said system comprising (a) Component I which functions to eliminate the existing microbial contamination load in a natural cosmetic formulation base through an optimized pasteurization method that avoids deep freezing; and (b) Component II that includes the step of adding synergistic blends of fractionated essential oils, extracts and isolated compounds to the pre-pasteurized cosmetic base obtained through the method of component I, wherein the synergistic blends sustain the effects of pasteurization through anti-microbial and anti-oxidant effects, said anti-oxidant effects enhancing further the anti-microbial effects by virtue of inhibiting lipid per oxidation that facilitates the undue proliferation of microbe.

Abstract: A system for selecting customized content for a user device is provided. The system includes a processor and an information extractor that, when executed by the processor, is configured to obtain at least one keyword from analyzing data entered into the user device. The system includes a behavioral engine that, when executed by the processor, is configured to obtain at least one keyword from analyzing a behavior of a user of the user device. The system also includes a keyword manager that, when executed by the processor, is configured to receive at least two keywords from the information extractor and/or the behavioral engine and to analyze the at least two keywords to obtain a prioritized list of keywords and to provide the prioritized list of keywords to a component that is configured to select customized content for the user device based on the prioritized list of keywords.

Abstract: The present disclosure relates generally to systems and methods for a mobile advertising and content caching mechanism for mobile devices and a method for using such a mechanism. In one example, the method includes monitoring a mobile device for activity indicating user interest in an advertising area. The method detects an application launch request corresponding to the monitored activity and intercepts the application launch request. The method provides multimedia advertising content to an output component of the mobile device, and launches the application corresponding to the application launch request after the multimedia advertising content has finished playing on the output component.