Abstract: Disclosed herein are methods and systems to predict, quantify, and present a patient's burden when participating in a clinical trial. A method includes gathering data associated with a clinical trial, such as receiving operational parameters of a new clinical trial. The method also includes executing one or more computer models to predict a quantified burden associated with the clinical trial including a patient burden score, a site burden score, and/or a burden cost. The method then includes presenting an interactive electronic platform that includes one or more graphical user interfaces configured to present the patient burden score(s) where when one or more operational attributes of the clinical trial is revised, the electronic platform revises the presented data accordingly.