Patents by Inventor GARIMA THAKUR

GARIMA THAKUR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11867673
    Abstract: The present invention relates to method of using spectroscopy for real time measuring of concentration of desired product and using measured data for monitoring and control of chromatography. It develops a method and system for measuring real-time concentration of clarified harvest and that of flow through of loading step of the chromatography and using measured data for determining breakthrough in real-time. The two modes of operation are used viz. first mode (Part A) uses a single near infrared spectroscopy (NIR) flow cell prior to the continuous chromatography column to ensure optimal loading in each cycle based on dynamic binding capacity studies carried out previously with the desired Protein A resin and second mode (Part B) uses two near infrared spectroscopy (NIR) flow cells, one before and one after the column, to detect the breakthrough curve (from 1% breakthrough onwards).
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: January 9, 2024
    Assignee: Indian Institute of Technology Delhi
    Inventors: Anurag Singh Rathore, Garima Thakur, Vishwanath Hebbi
  • Publication number: 20220283561
    Abstract: Process control of continuous production of biomolecules is a major challenge due to complex nature of processes and time scales of operations involved. Availability of key process variables in real-time is one of main requirements. This disclosure relates to a processor implemented method of controlling a continuous bioprocessing plant which includes at least one of: receiving, an input data associated with one or more equipments; generating, by a recipe builder, a sequence of unit operations to determine at least one job order based on the at least input data; obtaining, a control decision associated with a control parameter based on the at least one job order; communicating, via the middleware, the control decision associated with the control parameter to the PLC; and executing, by a control system of the PLC, the control decision on a unit equipment to control: (i) a continuous bioprocessing train, and (ii) an individual unit operation.
    Type: Application
    Filed: January 28, 2022
    Publication date: September 8, 2022
    Applicant: Tata Consultancy Services Limited
    Inventors: Venkata Sudheendra BUDDHIRAJU, Venkataramana RUNKANA, Vishnu Swaroopji MASAMPALLY, Anshul AGARWAL, Amey Ahsok KULKARNI, Keshari Nandan GUPTA, Navnath Manohar DEORE, Vinesh Balakrishnan YEZHUVATH, Anamika TIWARI, Anurag Singh RATHORE, Garima THAKUR, Nikita SAXENA, Shantanu BANERJEE
  • Publication number: 20220146416
    Abstract: The present invention relates to method of using spectroscopy for real time measuring of concentration of desired product and using measured data for monitoring and control of chromatography. It develops a method and system for measuring real-time concentration of clarified harvest and that of flow through of loading step of the chromatography and using measured data for determining breakthrough in real-time. The two modes of operation are used viz. first mode (Part A) uses a single near infrared spectroscopy (NIR) flow cell prior to the continuous chromatography column to ensure optimal loading in each cycle based on dynamic binding capacity studies carried out previously with the desired Protein A resin and second mode (Part B) uses two near infrared spectroscopy (NIR) flow cells, one before and one after the column, to detect the breakthrough curve (from 1% breakthrough onwards).
    Type: Application
    Filed: March 20, 2020
    Publication date: May 12, 2022
    Inventors: Anurag Singh RATHORE, Garima THAKUR, Vishwanath HEBBI
  • Publication number: 20220049206
    Abstract: Described herein is a surge tank based system to control surge tanks in a manufacturing train. The system includes data acquisition unit, data normalization unit, deviation identification and handling unit and an real time execution of control action from centralized computer in a manufacturing process unit, wherein said manufacturing unit includes an integrated system which incorporates a plurality of pumps, surge tanks, and weighing balances, and other unit operations alongside the normal unit operations of production of output product.
    Type: Application
    Filed: August 6, 2021
    Publication date: February 17, 2022
    Applicant: INDIAN INSTITUTE OF TECHNOLOGY DELHI
    Inventors: ANURAG S. RATHORE, GARIMA THAKUR, NIKITA SAXENA, ANAMIKA TIWARI