Abstract: A method of external genital cleansing and prophylactic kit are disclosed. The kit includes wipes having topical microbicides, personal lubricants, sterile water or sterile water-based solutions disposed on or impregnated therein. The wipes are packaged in conjunction with a condom and when used in accordance with the teaching of this invention work to inhibit transmission of STDs particularly including HIV. Wipes provided in the kit may be used to cleanse the external portions of the genitals before application of the provided condom. After removal of the condom, one or more wipes are to be used to cleanse the external portions of the genitals.