Patents by Inventor Garret Hampton

Garret Hampton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tmprss2 Regulatory Sequences and Uses Thereof
    Publication number: 20070275915
    Abstract: The present invention generally relates to substances and methods useful for the treatment of neoplastic disease. More specifically, it relates to cancer selective promoters and their use in oncolytic adenoviral vectors. The oncolytic adenoviral vectors are useful in methods of gene therapy. The promoters and the oncolytic adenoviral vectors are useful in methods for screening for compounds that modulate the expression of the cancer selective genes.
    Type: Application
    Filed: April 15, 2004
    Publication date: November 29, 2007
    Inventors: Paul Hallenbeck, Garret Hampton, Carl Hay, Ying Huang, John Jakubczak
  • Flap Endonuclease (Fen1) Regulatory Sequences And Uses Thereof
    Publication number: 20070212675
    Abstract: FEN1 transcriptional regulatory sequences (TREs) are provided. FEN1 TREs provide for transcriptional regulation dependent upon transcription factors that are only active in cancer cells. The FEN1 TREs may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity, for selective expression in cancer cells.
    Type: Application
    Filed: April 15, 2004
    Publication date: September 13, 2007
    Applicants: NOVARTIS AG, IRM LLC
    Inventors: Paul Hallenbeck, Garret Hampton, Carl Hay, Ying Huang, John Jakubczak, Sandrina Phipps
  • Methods and compositions for inducing apoptosis in cancer cells
    Publication number: 20070128204
    Abstract: Anti-DR5 antibody agonists, combined with apoptosis-inducing agents, synergistically induce apoptosis in cancer cells.
    Type: Application
    Filed: December 1, 2006
    Publication date: June 7, 2007
    Applicant: IRM LLC
    Inventors: Marc Nasoff, Quinn Deveraux, Deborah Knee, Pedro Aza-Blanc, Garret Hampton, Klaus Wagner
  • Differential tumor cytotoxicity compounds and compositions
    Patent number: 7125997
    Abstract: The invention is directed to novel biaryl derivatives, to the uses of these compounds in various medicinal applications, including the treatment, prevention and control of proliferative diseases such as tumors, and to pharmaceutical compositions comprising these compounds. Compounds of the invention can be used to treat or prevent diseases or disorders that involve the activity of MIF-1 and/or adenosine kinase.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: October 24, 2006
    Assignee: IRM LLC
    Inventors: Jason Chyba, Quinn Devereax, Garret Hampton, Fred King
  • Molecular signatures of commonly fatal carcinomas
    Publication number: 20060211025
    Abstract: This invention provides methods, kits, and algorithms for obtaining molecular signatures of cells based on their gene expression profiles. Devices for carrying out molecular signature analysis of unknown samples are also provided.
    Type: Application
    Filed: March 9, 2006
    Publication date: September 21, 2006
    Applicant: IRM LLC
    Inventors: Andrew Su, Garret Hampton
  • Genes overexpressed in prostate disorders as diagnostic and therapeutic targets
    Publication number: 20060134688
    Abstract: Disclosed are methods for diagnosing, monitoring the progression of, and treating a prostate disorder based upon genes that are differentially expressed in prostate disorders. Also disclosed are methods for identifying agents useful in the treatment of a prostate disorder, methods for monitoring the efficacy of a treatment for a prostate disorder, methods for inhibiting the proliferation of a prostate cell, and prostate-specific vectors including the promoter of these genes.
    Type: Application
    Filed: February 13, 2006
    Publication date: June 22, 2006
    Applicant: IRM LLC
    Inventors: John Welsh, Garret Hampton
  • Methods and compositions for inducing apoptosis in cancer cells
    Publication number: 20050079172
    Abstract: Anti-DR4 or Anti-DR5 antibody agonists, combined with apoptosis-inducing agents, synergistically induce apoptosis in cancer cells.
    Type: Application
    Filed: November 25, 2003
    Publication date: April 14, 2005
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Marc Nasoff, Quinn Deveraux, Deborah Knee, Pedro Aza-Blanc, Garret Hampton, Klaus Wagner
  • Differential tumor cytotoxicity compounds and compositions
    Publication number: 20040132786
    Abstract: The invention is directed to novel biaryl derivatives, to the uses of these compounds in various medicinal applications, including the treatment, prevention and control of proliferative diseases such as tumors, and to pharmaceutical compositions comprising these compounds. Compounds of the invention can be used to treat or prevent diseases or disorders that involve the activity of MIF-1 and/or adenosine kinase.
    Type: Application
    Filed: December 18, 2003
    Publication date: July 8, 2004
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Jason Chyba, Quinn Deveraux, Garret Hampton, Fred King