Patents by Inventor Garrett Lee
Garrett Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240141316Abstract: The present disclosure relates to methods, compositions, and kits for isolating target nucleic acids below a target size from a sample comprising nucleic acid components. In some embodiments, the methods involve one or more aqueous two-phase system (ATPS) compositions, at least one solid phase medium, and at least one buffer. Some embodiments provide a kit comprising one or more ATPS compositions, at least one solid phase medium, and at least one buffer. Other embodiments provide methods for diagnosing a disease or condition using the methods described herein.Type: ApplicationFiled: September 8, 2023Publication date: May 2, 2024Inventors: Vasu SAINI, Cheuk Yiu Tenny CHUNG, Daniel William BRADBURY, Harsha Madan KITTUR, Cheuk Yin LAM, Kar Kee TSE, Kit CHEUNG, Yin To CHIU, Garrett Lee MOSLEY
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Publication number: 20240141409Abstract: The present disclosure relates to methods, compositions, and kits for concentrating and purifying at least one target analyte from a clinical biological sample. In some embodiments, the methods involve one or more aqueous two-phase system (ATPS) compositions and at least one solid phase medium. Some embodiments provide a kit comprising one or more ATPS compositions, a binding buffer; and a solid phase medium. Other embodiments provide methods of treating cancers or infectious diseases in a patient in need thereof.Type: ApplicationFiled: September 8, 2023Publication date: May 2, 2024Inventors: Cheuk Yiu Tenny CHUNG, Vasu SAINI, Daniel William BRADBURY, Harsha Madan KITTUR, Masae Kobayashi WEN, Cheuk Yin LAM, Kar Kee TSE, Kit CHEUNG, Wing Yee NG, Yin To CHIU, Garrett Lee MOSLEY
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Patent number: 11875396Abstract: A system for displaying a simulated room can comprise a projector, a wall structure element, a physical object, and a room customization station. The room customization station can view images of selectable products and allows a selection thereof to be displayed on the wall structure element or the physical object. The projector can display the selectable product(s) on the wall structure element or the physical object. The physical object can be adjustable in size for different selectable product sizes. The system can include a physical accessory placeable in the simulated room to facilitate visualization of how the physical accessory would appear in the simulated room with the selectable product. Further, the room customization station can prevent a portion of the images from being projected onto a physical feature in the simulated room and allow other portions of the images to be projected into a portion of the simulated room.Type: GrantFiled: July 2, 2021Date of Patent: January 16, 2024Assignee: Lowe's Companies, Inc.Inventors: Blair Thomas Holt, Kurt James Jansen, Shannon Wadford Boggess, Randall Allen Miller, Paula Gragg Ferguson, Jeffrey Donald Key, Jeffrey Robert Pollard, Zeke Robert Markshausen, Garrett Lee Winther, Kathryn Soven, Carl David Sjunnesson, Kyle Fletcher, Elizabeth Spenko, Joseph Thomas Graceffa, Travis Schultz Lee, Aaron Randall Ferber
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Publication number: 20230211257Abstract: The present invention relates to a method and/or device for improving the separation behaviors and performance of aqueous two-phase system (ATPS) for the isolation and/or concentration of one or more target analytes from a sample. In one embodiment, the present method and device comprise ATPS components within a porous material and one or more phase separation behavior modifying agents that improve the separation behavior and performance characteristics of ATPS, including but not limited to the increasing the stability or reducing fluctuations of ATPS thought the adjustment of total volume of a sample solution that undergoes phase separation, volume ratio of the two phases of the ATPS, fluid flow rates, and concentrations of ATPS components.Type: ApplicationFiled: March 13, 2023Publication date: July 6, 2023Inventors: Yin To Chiu, Brian Sangwoo Lee, Garrett Lee Mosley, Beatrice S. Lim
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Patent number: 11633676Abstract: The present invention relates to a method and/or device for improving the separation behaviors and performance of aqueous two-phase system (ATPS) for the isolation and/or concentration of one or more target analytes from a sample. In one embodiment, the present method and device comprise ATPS components within a porous material and one or more phase separation behavior modifying agents that improve the separation behavior and performance characteristics of ATPS, including but not limited to the increasing the stability or reducing fluctuations of ATPS thought the adjustment of total volume of a sample solution that undergoes phase separation, volume ratio of the two phases of the ATPS, fluid flow rates, and concentrations of ATPS components.Type: GrantFiled: June 1, 2018Date of Patent: April 25, 2023Assignee: PHASE DIAGNOSTICS, INC.Inventors: Yin To Chiu, Brian Sangwoo Lee, Garrett Lee Mosley, Beatrice S. Lim
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Patent number: 11609232Abstract: This invention relates to a method and device for improving the accuracy and performance of detecting or diagnosing sexually transmitted infections (STIs) or STI-causing pathogens. In one embodiment, the present method and device are related to removing one or more interfering molecules such as urea from urine sample, where these interfering molecules alter the performance of Lateral-Flow Immunoassay (LFA). In one embodiment, an aqueous two-phase system (ATPS) embedded entirely within a porous material allows spontaneous phase separation and the target STI-causing pathogens is concentrated in one of the separated phases. In one embodiment, a detection module such as the Lateral-Flow Immunoassay (LFA) is used in connection with other modules so as to detect or diagnose the sexually transmitted infections or the pathogens associated with STIs with an improved performance.Type: GrantFiled: August 30, 2018Date of Patent: March 21, 2023Assignee: PHASE DIAGNOSTICS, INC.Inventors: Yin To Chiu, Garrett Lee Mosley, Brian Sangwoo Lee
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Publication number: 20220354938Abstract: The present invention provides cell-targeting molecules which can deliver a CD8+ T-cell epitope cargo to the MHC class I presentation pathway of a target cell. The cell-targeting molecules of the invention can be used to deliver virtually any CD8+ T-cell epitope from an extracellular space to the MHC class I pathway of a target cell, which may be a malignant cell and/or non-immune cell. The target cell can then display on a cell-surface the delivered CD8+ T-cell epitope complexed with MHC I molecule. The cell-targeting molecules of the invention have uses which include the targeted labeling and/or killing of specific cell-types within a mixture of cell-types, including within a chordate, as well as the stimulation of beneficial immune responses. The cell-targeting molecules of the invention have uses, e.g., in the treatment of a variety of diseases, disorders, and conditions, including cancers, tumors, growth abnormalities, immune disorders, and microbial infections.Type: ApplicationFiled: June 29, 2022Publication date: November 10, 2022Inventors: Eric POMA, Erin WILLERT, Sangeetha RAJAGOPALAN, Garrett Lee ROBINSON, Brigitte BRIESCHKE, Jason KIM
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Publication number: 20220281926Abstract: The present invention relates to Shiga toxin A Subunit derived polypeptides and cell-targeting molecules comprising amino acid substitutions which equip the polypeptides with 1) de-immunization; 2) reduced, protease-cleavage sensitivity; and/or 3) a heterologous epitope cargo(s) while retaining Shiga toxin function(s), such as, e.g., potent cytotoxicity. Certain polypeptides of the invention exhibit reduced immunogenic potential in mammals and/or are capable of delivering an epitope to an MHC class molecule of a cell in which the polypeptide is present. Certain molecules comprising a polypeptide of the invention are well-tolerated by mammals while retaining one or more of the features mentioned above.Type: ApplicationFiled: May 17, 2022Publication date: September 8, 2022Inventors: Eric POMA, Erin WILLERT, Garrett Lee ROBINSON, Sangeetha RAJAGOPALAN, Brigitte BRIESCHKE
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Publication number: 20220275030Abstract: The present invention relates to Shiga toxin effector polypeptides with reduced antigenic and/or immunogenic potential. Immunogenicity can be a limitation for the repeated administration to mammals of proteins and polypeptides derived from Shiga toxins. The Shiga toxin effector polypeptides of the present invention have uses as components of therapeutics, diagnostics, and immunization materials. The cytotoxic proteins of the present invention have uses for selective killing of specific cell types and as therapeutics for the treatment of a variety of diseases, including cancers, immune disorders, and microbial infections. The proteins of the present invention also have uses for detecting specific cell types, collecting diagnostic information, and monitoring the treatment of a variety of diseases, such as, e.g., cancers, immune disorders, and microbial infections.Type: ApplicationFiled: June 11, 2021Publication date: September 1, 2022Inventors: Eric Poma, Erin Willert, Garrett Lee Robinson, Sangeetha Rajagopalan, Brigitte Brieschke
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Patent number: 11406692Abstract: The present invention provides cell-targeting molecules which can deliver a CD8+ T-cell epitope cargo to the MHC class I presentation pathway of a target cell. The cell-targeting molecules of the invention can be used to deliver virtually any CD8+ T-cell epitope from an extracellular space to the MHC class I pathway of a target cell, which may be a malignant cell and/or non-immune cell. The target cell can then display on a cell-surface the delivered CD8+ T-cell epitope complexed with MHC I molecule. The cell-targeting molecules of the invention have uses which include the targeted labeling and/or killing of specific cell-types within a mixture of cell-types, including within a chordate, as well as the stimulation of beneficial immune responses. The cell-targeting molecules of the invention have uses, e.g., in the treatment of a variety of diseases, disorders, and conditions, including cancers, tumors, growth abnormalities, immune disorders, and microbial infections.Type: GrantFiled: April 12, 2021Date of Patent: August 9, 2022Assignee: Molecular Templates, Inc.Inventors: Eric Poma, Erin Willert, Sangeetha Rajagopalan, Garrett Lee Robinson, Brigitte Brieschke, Jason Kim
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Patent number: 11365223Abstract: The present invention relates to Shiga toxin A Subunit derived polypeptides and cell-targeting molecules comprising amino acid substitutions which equip the polypeptides with 1) de-immunization; 2) reduced, protease-cleavage sensitivity; and/or 3) a heterologous epitope cargo(s) while retaining Shiga toxin function(s), such as, e.g., potent cytotoxicity. Certain polypeptides of the invention exhibit reduced immunogenic potential in mammals and/or are capable of delivering an epitope to an MHC class molecule of a cell in which the polypeptide is present. Certain molecules comprising a polypeptide of the invention are well-tolerated by mammals while retaining one or more of the features mentioned above.Type: GrantFiled: April 19, 2021Date of Patent: June 21, 2022Assignee: Molecular Templates, Inc.Inventors: Eric Poma, Erin Willert, Garrett Lee Robinson, Sangeetha Rajagopalan, Brigitte Brieschke
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Publication number: 20210334890Abstract: A system for displaying a simulated room can comprise a projector, a wall structure element, a physical object, and a room customization station. The room customization station can view images of selectable products and allows a selection thereof to be displayed on the wall structure element or the physical object. The projector can display the selectable product(s) on the wall structure element or the physical object. The physical object can be adjustable in size for different selectable product sizes. The system can include a physical accessory placeable in the simulated room to facilitate visualization of how the physical accessory would appear in the simulated room with the selectable product. Further, the room customization station can prevent a portion of the images from being projected onto a physical feature in the simulated room and allow other portions of the images to be projected into a portion of the simulated room.Type: ApplicationFiled: July 2, 2021Publication date: October 28, 2021Inventors: Blair Thomas Holt, Kurt James Jansen, Shannon Wadford Boggess, Randall Allen Miller, Paula Gragg Ferguson, Jeffrey Donald Key, Jeffrey Robert Pollard, Zeke Robert Markshausen, Garrett Lee Winther, Kathryn Soven, Carl David Sjunnesson, Kyle Fletcher, Elizabeth Spenko, Joseph Thomas Graceffa, Travis Schultz Lee, Aaron Randall Ferber
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Publication number: 20210268085Abstract: The present invention provides cell-targeting molecules which can deliver a CD8+ T-cell epitope cargo to the MHC class I presentation pathway of a target cell. The cell-targeting molecules of the invention can be used to deliver virtually any CD8+ T-cell epitope from an extracellular space to the MHC class I pathway of a target cell, which may be a malignant cell and/or non-immune cell. The target cell can then display on a cell-surface the delivered CD8+ T-cell epitope complexed with MHC I molecule. The cell-targeting molecules of the invention have uses which include the targeted labeling and/or killing of specific cell-types within a mixture of cell-types, including within a chordate, as well as the stimulation of beneficial immune responses. The cell-targeting molecules of the invention have uses, e.g., in the treatment of a variety of diseases, disorders, and conditions, including cancers, tumors, growth abnormalities, immune disorders, and microbial infections.Type: ApplicationFiled: April 12, 2021Publication date: September 2, 2021Applicant: Molecular Templates, Inc.Inventors: Eric POMA, Erin WILLERT, Sangeetha RAJAGOPALAN, Garrett Lee ROBINSON, Brigitte BRIESCHKE, Jason KIM
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Publication number: 20210253649Abstract: The present invention relates to Shiga toxin A Subunit derived polypeptides and cell-targeting molecules comprising amino acid substitutions which equip the polypeptides with 1) de-immunization; 2) reduced, protease-cleavage sensitivity; and/or 3) a heterologous epitope cargo(s) while retaining Shiga toxin function(s), such as, e.g., potent cytotoxicity. Certain polypeptides of the invention exhibit reduced immunogenic potential in mammals and/or are capable of delivering an epitope to an MHC class molecule of a cell in which the polypeptide is present. Certain molecules comprising a polypeptide of the invention are well-tolerated by mammals while retaining one or more of the features mentioned above.Type: ApplicationFiled: April 19, 2021Publication date: August 19, 2021Inventors: Eric Poma, Erin Willert, Garrett Lee Robinson, Sangeetha Rajagopalan, Brigitte Brieschke
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Publication number: 20210248653Abstract: Systems and methods for authenticating products, such as products from original manufacturers and/or resellers, that provide a trusted and reliable mechanism for buyers and sellers to prove the authenticity of a product and for authenticators to establish an authentication that can be relied on during downstream transactions is provided. In some embodiments, a blockchain-based product authentication system is provided that allows entities within a chain of commerce (e.g., suppliers, manufacturers, distributors, retails, consumers, consignors, resellers) to verify the authenticity of items by way of trusted authenticators and trusted audit processes. The product authentication system enables users to rely on product authentications via off-channel sales with the use of cryptography, blockchain, digital assets, and tagging hardware and software.Type: ApplicationFiled: February 8, 2021Publication date: August 12, 2021Inventors: Addison David McKenzie, Yonathan Lapchik, Garrett Lee
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Patent number: 11062383Abstract: A system for displaying a simulated room can comprise at least one projector, at least one wall structure element, at least one physical object, and a room customization station. The room customization station can be configured to permit viewing images of selectable products and selecting at least one of the selectable products to be displayed on at least one of the at least one wall structure element or the at least one physical object. The projector(s) can be adapted to display the selectable product(s) on at least one of the at least one wall structure element or the physical object(s). The physical object can be adjustable in size to correspond to different sizes of selectable products. The system can further include at least one physical accessory adapted to be placed in the simulated room to facilitate visualization of how the at least one physical accessory would appear in the presence of the simulated room and the at least one selectable product.Type: GrantFiled: May 10, 2016Date of Patent: July 13, 2021Assignee: LOWE'S COMPANIES, INC.Inventors: Blair Thomas Holt, Kurt James Jansen, Shannon Wadford Boggess, Randall Allen Miller, Paula Gragg Ferguson, Jeffrey Donald Key, Jeffrey Robert Pollard, Zeke Robert Markshausen, Garrett Lee Winther, Kathryn Soven, Carl David Sjunnesson, Kyle Fletcher, Elizabeth Spenko, Joseph Thomas Graceffa, Travis Schultz Lee, Aaron Randall Ferber
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Publication number: 20200348303Abstract: This invention relates to a method and device for improving the accuracy and performance of detecting or diagnosing sexually transmitted infections (STIs) or STI-causing pathogens. In one embodiment, the present method and device are related to removing one or more interfering molecules such as urea from urine sample, where these interfering molecules alter the performance of Lateral-Flow Immunoassay (LFA). In one embodiment, an aqueous two-phase system (ATPS) embedded entirely within a porous material allows spontaneous phase separation and the target STI-causing pathogens is concentrated in one of the separated phases. In one embodiment, a detection module such as the Lateral-Flow Immunoassay (LFA) is used in connection with other modules so as to detect or diagnose the sexually transmitted infections or the pathogens associated with STIs with an improved performance.Type: ApplicationFiled: August 30, 2018Publication date: November 5, 2020Inventors: Yin To CHIU, Garrett Lee MOSLEY, Brian Sangwoo LEE
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Publication number: 20200318153Abstract: This invention relates to a method and device to improve the detection accuracy and performance for diagnosing dental disorders or diseases by improving the sensitivity of the Lateral-Flow Immunoassay (LFA). The present method and device are related to removing the protein interference (impurities) from sample and using aqueous two-phase system (ATPS) embedded entirely within a porous material, allowing spontaneous phase separation and concentration, for detection using the Lateral-Flow Immunoassay (LFA). The present invention also provides a platform technology for screening different types of specimens with increased sensitivity, and screening antibodies for optimal detection in various types of samples.Type: ApplicationFiled: August 30, 2018Publication date: October 8, 2020Inventors: Yin To CHIU, Garrett Lee MOSLEY, Brian Sangwoo LEE
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Publication number: 20200197833Abstract: The present invention relates to a method and/or device for improving the separation behaviors and performance of aqueous two-phase system (ATPS) for the isolation and/or concentration of one or more target analytes from a sample. In one embodiment, the present method and device comprise ATPS components within a porous material and one or more phase separation behavior modifying agents that improve the separation behavior and performance characteristics of ATPS, including but not limited to the increasing the stability or reducing fluctuations of ATPS thought the adjustment of total volume of a sample solution that undergoes phase separation, volume ratio of the two phases of the ATPS, fluid flow rates, and concentrations of ATPS components.Type: ApplicationFiled: June 1, 2018Publication date: June 25, 2020Applicant: Phase Scientific International, LtdInventors: Yin To Chiu, Brian Sangwoo Lee, Garrett Lee Mosley, Beatrice S. Lim
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Patent number: 10561866Abstract: A cushioning apparatus is described for use with a safety harness used to aid in back, neck, and head support. The cushioning apparatus can easily be added to most safety harnesses in use today. The cushioning apparatus comprises a back (and perhaps shoulder) support pad, used in combination with an adjustable head and neck rest. The head rest may also be made to pivot forward and back. The neck rest is preferably attached to the back support pad via a support plate disposed on a rear surface of the back support pad.Type: GrantFiled: October 5, 2017Date of Patent: February 18, 2020Inventor: Garrett Lee Hinnant