Abstract: An orbital atherectomy system includes a handheld driver having a motor. An elongate flexible driveshaft has a proximal end portion and a distal end portion. The proximal end portion is drivably coupled to the motor. The distal end portion defines a rotational axis. An abrasive element is fixedly disposed on the distal end portion of the elongate flexible driveshaft. The abrasive element includes a first flat side, a second flat side, a leading tapered end portion having a leading end, and a trailing tapered end portion having a trailing end. The first flat side and the second flat side are on opposite sides of the rotational axis.

Abstract: A method of manufacturing a heart valve prosthesis includes cutting a flat sheet of a valve material into a single-piece valve pattern having two or more valve leaflet regions and a valve skirt region. The method also includes arranging the two or more valve leaflet regions of the single-piece valve pattern into a mold for forming a leaflet belly for each of the two or more valve leaflet regions. Further, the method includes fixing, while arranged in the mold, a shape of the leaflet belly of each of two or more valve leaflet regions of the single piece-valve pattern. The method additionally includes creating a side seam by attaching two longitudinal edges of the single-piece valve pattern, to thereby form a tubular valve subassembly with two or more valve leaflets. The method includes attaching the tubular valve subassembly within a tubular frame to form a heart valve prosthesis.

Abstract: The presence of analytes can be detected in the bodily fluid using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (ECS) in devices, such as handheld point-of-care devices. The devices, as well as systems and methods, utilize using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (EIS) in combination with an antibody or other target-capturing molecule on a working electrode. Imaginary impedance or phase shift, as well as background subtraction, also may be utilized.

Abstract: A human motion assistance device has an upper torso harness for attaching to a user. The upper torso harness has a backpack assembly and shoulder strap, which buckles in front of the user. The upper torso harness can be IOTV. Leg straps are affixed to the upper torso harness proximate to a gluteal area of the user and configured to extend down a hamstring area to a knee pad and further extend down a tibia area. The knee pad opens along a vertical or angled segment and the calf portion opens over the calf. Seat webbing is connected to leg straps for additional support. Upper torso harness and leg straps are made with a combination of durable materials such as textured nylon, polyurethane coated polyester, as well as elastic material and webbing material. The upper torso harness and leg straps are passive without active members.

Abstract: The presence of analytes can be detected in the bodily fluid using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (ECS) in devices, such as handheld point-of-care devices. The devices, as well as systems and methods, utilize using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (EIS) in combination with an antibody or other target-capturing molecule on a working electrode. Imaginary impedance or phase shift, as well as background subtraction, also may be utilized.

Abstract: A blood glucose sensing device includes a substrate, multiple three-dimensionally (3D) printed electrode leads comprising graphene arranged on or over the substrate, and glucose monitoring chemistry arranged in or on (e.g., adsorbed in) at least one of the 3D printed electrode leads. An end portion of a counter electrode lead may partially surround an end portion of a working electrode lead, and a reference lead may be further provided, Optionally, the 3D printed electrode leads may include a thermoplastic material, such as an aliphatic polyester. The glucose monitoring chemistry may include an enzyme.

Abstract: A human motion assistance device has an upper torso harness for attaching to a user. The upper torso harness has a shoulder strap or backpack assembly. A belt is connected to the upper torso harness and extends around a waist and back area of the user. Leg straps are affixed to the upper torso harness proximate to a gluteal area of the user and configured to extend down a hamstring area to cross in front of a knee area and further extend down a calf area to a foot anchor. The leg straps are made of an elastic material with a pocket around the knee area of the user. The foot anchor may extend under the heel to an arch strap, or cross over the talus and under the arch of the foot. The upper torso harness and leg straps are passive without active members.

Abstract: A blood glucose sensing device includes a substrate, multiple three-dimensionally (3D) printed electrode leads comprising graphene arranged on or over the substrate, and glucose monitoring chemistry arranged in or on (e.g., adsorbed in) at least one of the 3D printed electrode leads. An end portion of a counter electrode lead may partially surround an end portion of a working electrode lead, and a reference lead may be further provided, Optionally, the 3D printed electrode leads may include a thermoplastic material, such as an aliphatic polyester. The glucose monitoring chemistry may include an enzyme.

Abstract: A human motion assistance device has an upper torso harness for attaching to a user. The upper torso harness has a backpack assembly and shoulder strap, which buckles in front of the user. The upper torso harness can be IOTV. Leg straps are affixed to the upper torso harness proximate to a gluteal area of the user and configured to extend down a hamstring area to a knee pad and further extend down a tibia area. The knee pad opens along a vertical or angled segment and the calf portion opens over the calf. Seat webbing is connected to leg straps for additional support. Upper torso harness and leg straps are made with a combination of durable materials such as textured nylon, polyurethane coated polyester, as well as elastic material and webbing material. The upper torso harness and leg straps are passive without active members.

Abstract: A human motion assistance device has an upper torso harness for attaching to a user. The upper torso harness has a shoulder strap or backpack assembly. A belt is connected to the upper torso harness and extends around a waist and back area of the user. Leg straps are affixed to the upper torso harness proximate to a gluteal area of the user and configured to extend down a hamstring area to cross in front of a knee area and further extend down a calf area to a foot anchor. The leg straps are made of an elastic material with a pocket around the knee area of the user. The foot anchor may extend under the heel to an arch strap, or cross over the talus and under the arch of the foot. The upper torso harness and leg straps are passive without active members.