Abstract: A photocurable material having a microfluidic endoskeleton constructed in a flexible polymeric slab is disclosed. The flexible polymeric slab comprises a first flexible polymeric sheet with microchannel network embedded thereon and a second flexible polymeric sheet sealed to the first flexible polymeric sheet. The microchannel network is filled with a photocurable fluid that may be solidified upon exposure to an activated light to create a rigid endoskeleton within the slab. The flexible polymeric sheet may be polydimethylsiloxane (PDMS). The process allows preserving a user-defined shape by illumination of the material. The disclosed photocured shaped PDMS slab with microfluidic skeleton has enhanced tensile stress-strain properties, elastomeric modulus and bending modulus compared to the PDMS slab without the photocured microfluidic skeleton.