Abstract: An electrochemical sensor apparatus for introducing a needle electrode into the skin of a subject to contact a biological fluid or a tissue in the subject and detect a target analyte. The apparatus has a movable portion which urges the needle electrode in the subject's skin and a power management function to supply operational power to the sensor electronics around the time that the apparatus is deployed.

Abstract: Provided is a computer-implemented method for predicting a pharmacokinetic feature for a drug administered to a subject, such as maximum concentration or time to maximum concentration. The method includes: contacting a fluid of the subject with an electrochemical aptamer-based sensor capable of detecting the drug, receiving a series of output values of the electrochemical aptamer-based sensor over a period of time, and using the series of output values to predict the pharmacokinetic feature.

Abstract: An electrochemical sensor apparatus for introducing a needle electrode into the skin of a subject to contact a biological fluid or a tissue in the subject and detect a target analyte. The apparatus has a movable portion which urges the needle electrode in the subject's skin and a thermal energy sensor to determine a temperature of the biological fluid or the tissue.

Abstract: An electrochemical sensor apparatus for introducing a needle electrode into the skin of a subject to contact a biological fluid or a tissue in the subject and detect a target analyte. The apparatus has a movable portion which urges the needle electrode in the subject's skin and means for controlling the movement of the needle electrode. Upon actuation of the sensor apparatus, the needle electrode is urged instantaneously and irreversibly into the skin.

Abstract: An electrochemical sensor apparatus for introducing a needle electrode into the skin of a subject to contact a biological fluid or a tissue in the subject and detect a target analyte, and methods of producing the apparatus. The apparatus has a movable portion which urges the needle electrode in the subject's skin and at least two needle electrodes are selected from a library to provide the apparatus with a multiplexing capacity.

Abstract: Provided is computer-implemented method for administering a drug to a subject. The method includes administering the drug to the subject using a controllable pump, contacting a fluid of the subject, such as interstitial fluid in situ, with an electrochemical aptamer-based sensor capable of detecting the drug, receiving a series of output values of the electrochemical aptamer-based sensor over a period of time, and using the series of output values to control the pump.

Abstract: A device for separating, treating and rejoining objects includes a process wheel for transporting bottom and cover pieces of the objects, a separating device, and an insert device for inserting the pieces in the process wheel. The process wheel has a first lower receiving ring with a first radius and a second upper receiving ring with a second smaller radius which are jointly rotatable as a unit. A wheel assembly is arranged between the separating device and the process wheel. The wheel assembly has a first lower wheel with bottom holders distributed around the periphery and a second upper wheel with cover holders for the cover pieces distributed around the periphery. The bottom holders and/or the cover holders in the circumferential direction are larger than the received bottom pieces or cover pieces such that, in operation, they surround the bottom or cover pieces with a compensation play.

Abstract: A device for separating, treating and rejoining objects includes a process wheel for transporting bottom and cover pieces of the objects, a separating device, and an insert device for inserting the pieces in the process wheel. The process wheel has a first lower receiving ring with a first radius and a second upper receiving ring with a second smaller radius which are jointly rotatable as a unit. A wheel assembly is arranged between the separating device and the process wheel. The wheel assembly has a first lower wheel with bottom holders distributed around the periphery and a second upper wheel with cover holders for the cover pieces distributed around the periphery. The bottom holders and/or the cover holders in the circumferential direction are larger than the received bottom pieces or cover pieces such that, in operation, they surround the bottom or cover pieces with a compensation play.

Abstract: A wearable apparatus for maintaining microneedles or other types of skin penetrating projections in contact with the interstitial fluid of the skin is disclosed. The apparatus has a skin contacting portion and a movable portion bearing the microneedles. The microneedles are initially in a retracted state, and are urged into the skin by movement of the movable portion along a non-linear, or arcuate path. The apparatus has a low profile when retained on the skin and is therefore less intrusive for extended wear applications such as continuous analyte monitoring and slow release drug delivery.

Abstract: The invention disclosed herein relates to a sample treatment device. The sample treatment device can include a bore comprising at least one chamber, wherein the at least one chamber, or multiple chambers, is formed by using partitions to define the chamber inside the device bore. The chambers can be formed by having a single shaft that is adapted to be moved longitudinally through the bore of the device, the shaft having sealing elements formed on or as part of the shaft, wherein the sealing elements create a seal with the interior bore wall, wherein the separate chambers defined by the interior bore wall and the sealing elements are formed by the spaces between the sealing elements. The chambers of the sample treatment device disclosed herein can be suitable for performing mixing, chemical reaction, heating, cooling, separation and/or washing steps using a simple to manufacture device, where one or all of the steps can be conducted for a desired or predetermined time.

Abstract: An electrochemical sensing apparatus and methods are provided. In one embodiment, an apparatus is provided having a carrier that supports an electrochemical module and that communicates between electrodes on the electrochemical module and an analyte measurement device.

Abstract: An electrochemical sensing apparatus and methods are provided. In one embodiment, an apparatus is provided having a carrier that supports an electrochemical module and that communicates between electrodes on the electrochemical module and an analyte measurement device.

Abstract: An electrochemical sensing apparatus and methods are provided. In one embodiment, an apparatus is provided having a carrier that supports an electrochemical module and that communicates between electrodes on the electrochemical module and an analyte measurement device.

Abstract: Disclosed herein are expanded ionomer materials including a plurality of voids. Also disclosed are methods of making and using the expanded ionomer materials.

Abstract: Disclosed herein are fuel cell elements including at least one electronically conductive layer and an ion conductive layer. The fuel cell elements can have a tubular cross-section or an enclosed cross-section of another shape. Also disclosed is an assembly of fuel cell elements to form cell tubes and stacks of such fuel cell elements or cell tubes. Fuel cell elements, or cell tubes, or stacks thereof can also be used as an electrolyser. Further disclosed are methods of making such fuel cell elements, cell tubes and stacks thereof, as well as methods of using the same.

Abstract: Electrochemical sensors for investigating a physiological sample and methods of manufacture are disclosed. The sensor includes a longitudinally extending reaction cell, having electrodes and a reagent, and laterally spaced electrical contact points for electrically communication with a meter. An array of such sensors is further disclosed including connective flaps for joining adjacent sensors. In use, the array of sensors can be stored in a folded configuration and dispensed individually.

Abstract: An electrochemical sensing apparatus and methods are provided. In one embodiment, an apparatus is provided having a carrier that supports an electrochemical module and that communicates between electrodes on the electrochemical module and an analyte measurement device.

Abstract: Electrochemical sensors for investigating a physiological sample and methods of manufacture are disclosed. The sensor includes an electrochemical reaction cell, having electrodes and a reagent, and laterally spaced electrical contact points for electrically communication with a meter. Further described herein is a multi-chambered sensor having an electrochemical reaction cell and an immunological cell. The multi-chambered cell can also include a pre-chamber.

Abstract: A microfluidic device for transferring liquid from a first chamber to a second chamber is provided. The device has a first chamber; a second chamber; and a barrier between the first chamber and the second chamber, the barrier having least one opening fluidly connecting the first chamber to the second chamber, the at least one opening being sized such that a retention force, such as surface tension, keeps the liquid in the first chamber. The fluid is transferred from the first chamber to the second chamber when an initiation input such as fluid pressure is introduced to the liquid that is sufficient to overcome the retention force. The device may be a sensor strip.

Abstract: The present invention relates to electrochemical cells including a connector which mates with a connection device to provide electrical connection to meter circuitry.