Abstract: A bottom dump trailer cart which includes a cargo compartment having a floor equipped with downwardly pivoting dumping panels is constructed such that the panels protect the wheels from the dumped cargo. The cart is capable of riding over the dumped cargo because of the absence of an axle connecting wheels on opposite sides of the cart, and the provision of a rear wall of the compartment which can be caused to pivot upwardly and rearwardly. A tongue assembly extends forwardly of the cargo compartment. An operating mechanism having expanding hinges enables conversion between a dumping state wherein the dumping panels and rear wall are caused to be free-swinging, and a locked transport state wherein the dumping panels are upwardly secured and the rear wall is secured in a vertical position.

Abstract: Associative portions of antibody light and heavy chains, especially Fv fragments, are expressed in a transformed organism as a single peptide chain connected by a linking peptide. This is cleaved, possibly while peptide synthesis is incomplete, by an enzyme of the transformed organism which is expressing the single peptide. This ensures production of both chains in equal amounts, but produces them as separate chains which are free to associate and fold.