Patents by Inventor Garry Duffy
Garry Duffy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250009843Abstract: The invention relates to a peptide drug for use as a localized antimicrobial agent and/or in the localised modulation of nerve cell activity, cardiomyocyte or muscle cell electrical activity in a subject, wherein the peptide drug comprises a polymer in a carrier, and further comprising: i) a plurality of cationic peptides, or an amino acid monomer thereof, covalently bound to the polymer; and/or ii) a plurality of cationic peptides, or an amino acid monomer thereof, mixed with the polymer. The invention further relates to the use of CARPs for use in the localised modulation of nerve cell activity, cardiomyocyte or muscle cell electrical activity in a subject. The invention further relates to modulation of chondrocyte function.Type: ApplicationFiled: November 16, 2022Publication date: January 9, 2025Inventors: David FINN, Mehnaz FERDOUSI, Alison LIDDY, Barry MCDERMOTT, Leo QUINLAN, Garry DUFFY, Tapas MITRA
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Patent number: 11690936Abstract: Embodiments herein relate to cell encapsulation membranes, devices including the same, and related methods. In an embodiment, a cell encapsulation membrane is included. The cell encapsulation membrane can include a mesh substrate. The mesh substrate can include a first series of fibers extending in a first direction and a second series of fibers extending in a second direction, the first series of fibers intersecting with the second series of fibers, the mesh substrate defining a plurality of apertures disposed between adjacent fibers of the first series and the second series. The cell encapsulation membrane can further include a coating disposed on the mesh substrate, the coating partially occluding the plurality of apertures defined by the mesh substrate and forming pores. Other embodiments are also included herein.Type: GrantFiled: April 5, 2021Date of Patent: July 4, 2023Assignee: Boston Scientific LimitedInventors: Martin Lawrence Fawdry, Aiden Flanagan, Matthew McEvaddy, Garry Duffy, Eamonn J. Tuohy
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Publication number: 20230126053Abstract: A room temperature injectable thermo-responsive hydrogel comprises a P407 poloxamer base hydrogel, chitosan, 2-Hydroxypropyl ?-cyclodextrin and genipin. The chitosan and genipin form an interpenetrating scaffold within the hydrogel in which the chitosan is crosslinked with genipin. Chemotherapeutic drugs can be added to the hydrogel singly or in combination in effective amounts without any loss of thermo-responsiveness in the hydrogel. Therapeutic use of the thermo-responsive hydrogel in the intratumoural treatment of solid cancer is also described.Type: ApplicationFiled: November 2, 2022Publication date: April 27, 2023Inventors: Helena Kelly, Garry Duffy, Seona Rossi, Conn Hastings
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Publication number: 20230094196Abstract: An implantable medical device having a soft tissue interfacing surface comprises at least one soft actuatable capsule having a soft tissue interfacing deflectable membrane configured for cyclical deflection upon actuation of the capsule to modulate the biomechanics of the soft tissue interface during use. The actuatable capsule may comprise an actuation chamber containing a first fluid, a therapeutic chamber containing a second fluid, a deflectable membrane separating the actuation chamber and therapeutic chamber, and an actuation conduit in fluidic communication with the actuation chamber for pneumatic actuation of the actuation chamber. The therapeutic chamber comprises the soft tissue interfacing deflectable membrane which is configured to cyclically deflect during actuation of the capsule and modulate the biomechanics of the soft tissue interface by altering one or more of strain, fluid flow and cellular activity in peri-implant tissue at the soft tissue interface.Type: ApplicationFiled: June 29, 2020Publication date: March 30, 2023Applicants: NATIONAL UNIVERSITY OF IRELAND, GALWAY, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Ellen ROCHE, Eimear DOLAN, Garry DUFFY, Sandra ROTHENBUCHER, William WHYTE, Claudia VARELA, Scott ROBINSON, Keegan MENDEZ
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Patent number: 11534401Abstract: A room temperature injectable thermo-responsive hydrogel comprises a P407 poloxamer base hydrogel, chitosan, 2-Hydroxypropyl ?-cyclodextrin and genipin. The chitosan and genipin form an interpenetrating scaffold within the hydrogel in which the chitosan is crosslinked with genipin. Chemotherapeutic drugs can be added to the hydrogel singly or in combination in effective amounts without any loss of thermo-responsiveness in the hydrogel. Therapeutic use of the thermo-responsive hydrogel in the intratumoural treatment of solid cancer is also described.Type: GrantFiled: November 7, 2018Date of Patent: December 27, 2022Assignee: THE ROYAL COLLEGE OF SURGEONS IN IRELANDInventors: Helena Kelly, Garry Duffy, Seona Rossi, Conn Hastings
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Publication number: 20220064378Abstract: A star polypeptide for use as a medicament, the star polypeptide comprising or consisting of a core and polypeptide arms radiating from the core. The star polypeptide may be used to deliver a therapeutic cargo and/or for its intrinsic properties. Therapeutic cargoes include a protein(e.g. VEGF); a nucleic acid (e.g. in vitro transcribed mRNA or microRNA); and/or a drug (e.g. diclofenac, azithromycin and/or rifampicin). Intrinsic properties include osteogenesis, angiogenesis and inhibition of bacteria.Type: ApplicationFiled: December 23, 2019Publication date: March 3, 2022Inventors: Sally-Ann Cryan, Andreas Heise, David Walsh, Joanne O'Dwyer, Fergal O'Brien, Garry Duffy
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Publication number: 20220054323Abstract: A pressure sensing clip (1) and a system including a bandage (19) for detecting and displaying the pressure applied by a (compression) bandage (19) to a human or animal body in which the pressure sensing clip (1) has an inner bandage penetrating arm (2) and an outer arm (3) hingedly attached to the inner arm (2) at a hinge (4) so that the outer arm (3) is movable between a hingedly closed position with respect to the inner arm (2) and a hingedly open position. The device can be operatively attached to an applied compression bandage, or it can be placed beneath or between the bandage during bandage application so that the bandage covers the sensing part of the device. In the latter application, the ability of the arms of the device to adapt an open configuration allows the bandage to be applied over the inner arm leaving the outer arm to close once the bandage has been applied. The device can receive, store and transmit data to a user.Type: ApplicationFiled: December 18, 2019Publication date: February 24, 2022Inventors: Andrew CAMERON, Garry DUFFY, Scott ROBINSON, Jaime PUNTER-VILLAGRASA, Myles MCGARRIGLE, Georgina GETHIN, Mary-Paula COLGAN, Faisal SHARIF, Muhammad Adnan ELAHI
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Publication number: 20220016219Abstract: The present application relates to a pharmaceutical composition for use in a method of treating diabetes in a human or animal subject in need thereof, to transplantation devices comprising the pharmaceutical composition of the present invention and to methods of treating diabetes using the pharmaceutical composition and transplantation device of the present invention.Type: ApplicationFiled: July 28, 2021Publication date: January 20, 2022Applicant: Eberhard Karls Universitaet Tuebingen Medizinische FakultaetInventors: Shannon Layland, Katja Schenke-Layland, Garry Duffy, Svenja Hinderer, Aline Zbinden
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Publication number: 20210220524Abstract: Embodiments herein relate to cell encapsulation membranes, devices including the same, and related methods. In an embodiment, a cell encapsulation membrane is included. The cell encapsulation membrane can include a mesh substrate. The mesh substrate can include a first series of fibers extending in a first direction and a second series of fibers extending in a second direction, the first series of fibers intersecting with the second series of fibers, the mesh substrate defining a plurality of apertures disposed between adjacent fibers of the first series and the second series. The cell encapsulation membrane can further include a coating disposed on the mesh substrate, the coating partially occluding the plurality of apertures defined by the mesh substrate and forming pores. Other embodiments are also included herein.Type: ApplicationFiled: April 5, 2021Publication date: July 22, 2021Inventors: Martin Lawrence Fawdry, Aiden Flanagan, Matthew McEvaddy, Garry Duffy, Eamonn J. Tuohy
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Patent number: 10967102Abstract: Embodiments herein relate to cell encapsulation membranes, devices including the same, and related methods. In an embodiment, a cell encapsulation membrane is included. The cell encapsulation membrane can include a mesh substrate. The mesh substrate can include a first series of fibers extending in a first direction and a second series of fibers extending in a second direction, the first series of fibers intersecting with the second series of fibers, the mesh substrate defining a plurality of apertures disposed between adjacent fibers of the first series and the second series. The cell encapsulation membrane can further include a coating disposed on the mesh substrate, the coating partially occluding the plurality of apertures defined by the mesh substrate and forming pores. Other embodiments are also included herein.Type: GrantFiled: September 27, 2017Date of Patent: April 6, 2021Assignee: Boston Scientific LimitedInventors: Martin Lawrence Fawdry, Aiden Flanagan, Matthew McEvaddy, Garry Duffy, Eamonn J. Tuohy
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Publication number: 20200360281Abstract: A room temperature injectable thermo-responsive hydrogel comprises a P407 poloxamer base hydrogel, chitosan, 2-Hydroxypropyl ?-cyclodextrin and genipin. The chitosan and genipin form an interpenetrating scaffold within the hydrogel in which the chitosan is crosslinked with genipin. Chemotherapeutic drugs can be added to the hydrogel singly or in combination in effective amounts without any loss of thermo-responsiveness in the hydrogel. Therapeutic use of the thermo-responsive hydrogel in the intratumoural treatment of solid cancer is also described.Type: ApplicationFiled: November 7, 2018Publication date: November 19, 2020Inventors: Helena Kelly, Garry Duffy, Seona Rossi, Conn Hastings
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Publication number: 20180085494Abstract: Embodiments herein relate to cell encapsulation membranes, devices including the same, and related methods. In an embodiment, a cell encapsulation membrane is included. The cell encapsulation membrane can include a mesh substrate. The mesh substrate can include a first series of fibers extending in a first direction and a second series of fibers extending in a second direction, the first series of fibers intersecting with the second series of fibers, the mesh substrate defining a plurality of apertures disposed between adjacent fibers of the first series and the second series. The cell encapsulation membrane can further include a coating disposed on the mesh substrate, the coating partially occluding the plurality of apertures defined by the mesh substrate and forming pores. Other embodiments are also included herein.Type: ApplicationFiled: September 27, 2017Publication date: March 29, 2018Inventors: Martin Lawrence Fawdry, Aiden Flanagan, Matthew McEvaddy, Garry Duffy, Eamonn J. Tuohy