Abstract: The invention provides a long-acting parathyroid hormone peptide (PTH) that is retained in a subject's blood serum for periods of time that greatly exceed the natural hormone. The long-acting PTH is conjugated to at the carbon 3 position of a non-hormonal vitamin D via a scaffold of discreet length that facilitates its purification, detection, solubility, and efficacy at the PTH receptor (PTHR). The PTH may be conjugated to the non-hormonal vitamin D via a 36 mer poly(ethylene glycol) moiety (PTH-PEG36-VitD). The invention also provides optimized manufacturing methods and formulations. The PTH-PEG36-VitD has a vastly-improved serum half-life and bioavailability when compared to a non-conjugated PTH peptide. PTH-PEG36-VitD also significantly increases serum calcium, reduces urinary calcium, and reduces serum phosphate.

Abstract: A computing system for enabling the analysis of multiple raw data sets whilst protecting the privacy of information within the raw data sets, the system comprising a plurality of synthetic data generators and a data hub. Each synthetic data generator is configured to: access a corresponding raw data set stored in a corresponding one of a plurality of raw data stores; produce, based on the corresponding raw data set, a synthetic data generator model configured to generate a synthetic data set representative of the corresponding raw data set; and push synthetic information including at least one of the corresponding synthetic data set and the synthetic data generator model to the data hub. The data hub is configured to store the synthetic information received from the synthetic data generators for access by one or more clients for analysis.