Abstract: Disclosed are molecules useful in the treatment or prevention of viral infections in humans and animals and/or the treatment or prevention of the associated symptoms, diseases and/or conditions. The disclosure provides molecules which comprise sugar (carbohydrate/polysaccharide/sialic acid/glycan)-binding protein(s) which are useful in the treatment or prevention of Coronavirus infections and/or diseases, symptoms and/or conditions caused or contributed to by the same.

Abstract: The present disclosure provides novel adjuvants which may be used in combination with one or more antigens to augment, modulate or enhance a host immune response to the one or more antigens. The adjuvants are based on sialic acid binding molecules and may be combined with any type of antigen. The adjuvants may be formulated for mucosal and/or intranasal administration.

Abstract: The disclosure provides molecules with an affinity for (or an ability to bind to), sialic acid, for use in compositions, medicaments and methods for the treatment of sepsis, its symptoms and sepsis associated pathologies and immune responses.

Abstract: The disclosure provides molecules with an affinity for (or an ability to bind to), sialic acid, for use in compositions, medicaments and methods for the treatment of sepsis, its symptoms and sepsis associated pathologies and immune responses.

Abstract: The present invention is based on the finding that in addition to interfering with or blocking, preventing and/or inhibiting the interaction between a pathogen and, for example, a sialic acid containing cell surface receptor, certain sialic acid binding molecules have immunomodulatory properties. The invention provides methods and uses which exploit sialic acid binding molecules in the treatment and/or prevention of disease by modulation and/or priming of the host immune response.

Abstract: The present disclosure provides novel adjuvants which may be used in combination with one or more antigens to augment, modulate or enhance a host immune response to the one or more antigens. The adjuvants are based on sialic acid binding molecules and may be combined with any type of antigen. The adjuvants may be formulated for mucosal and/or intranasal administration.

Abstract: The present invention is based on the finding that in addition to interfering with or blocking, preventing and/or inhibiting the interaction between a pathogen and, for example, a sialic acid containing cell surface receptor, certain sialic acid binding molecules have immunomodulatory properties. The invention provides methods and uses which exploit sialic acid binding molecules in the treatment and/or prevention of disease by modulation and/or priming of the host immune response.

Abstract: The present invention provides compounds, compositions, medicaments and methods comprising or using carbohydrate binding molecules. More specifically, the invention provides a means of treating diseases and/or conditions caused or contributed to by pathogens, particularly microbial pathogens and methods of screening, identifying, detecting tagging and/or labelling carbohydrates.

Abstract: A loudspeaker grille is disclosed. In accordance with one example, a loudspeaker grille includes a louver arrangement to be arranged in front of a chassis of a loudspeaker to protect membrane and suspension thereof. The louver arrangement includes a first and a second louver arranged on opposing sides of a center plane. Both louvers include a plurality of fins which are arranged slanted with respect to the center plane and which are spaced such that a clearance is provided between projections of neighboring fins to the center plane. The fins of the first louver are inversely slanted to the fins of the second louver. Further, the fins of the first louver are shifted in a lateral direction within the to center plane with respect to the fins of the second louver.

Abstract: A loudspeaker grille is disclosed. In accordance with one example, a loudspeaker grille includes a louver arrangement to be arranged in front of a chassis of a loudspeaker to protect membrane and suspension thereof. The louver arrangement includes a first and a second louver arranged on opposing sides of a center plane. Both louvers include a plurality of fins which are arranged slanted with respect to the center plane and which are spaced such that a clearance is provided between projections of neighboring fins to the center plane. The fins of the first louver are inversely slanted to the fins of the second louver. Further, the fins of the first louver are shifted in a lateral direction within the to center plane with respect to the fins of the second louver.

Abstract: The present invention provides compounds, compositions, medicaments and methods comprising or using carbohydrate binding molecules. More specifically, the invention provides a means of treating diseases and/or conditions caused or contributed to by pathogens, particularly microbial pathogens and methods of screening, identifying, detecting tagging and/or labelling carbohydrates.

Abstract: Novel paramyxovirus hemagglutinin-neuraminidase active site and methods for enabling the design and selection of inhibitors with that active site are provided. Also provided is machine-readable data storage medium comprising structure coordinates of the novel paramyxovirus hemagglutinin-neuraminidase active site.