Patents by Inventor Garth D. Ehrlich

Garth D. Ehrlich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biosynthetic pathway for heterologous expression of a nonribosomal peptide synthetase drug and analogs
    Patent number: 9611491
    Abstract: The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: April 4, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, ALLEGHENY-SINGER RESEARCH INSTITUTE, COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: David H. Sherman, Garth D. Ehrlich, Benjamin Janto, Robert M. Williams, Christopher M. Rath
  • BIOSYNTHETIC PATHWAY FOR HETEROLOGOUS EXPRESSION OF A NONRIBOSOMAL PEPTIDE SYNTHETASE DRUG AND ANALOGS
    Publication number: 20150050704
    Abstract: The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.
    Type: Application
    Filed: August 25, 2014
    Publication date: February 19, 2015
    Inventors: David H. Sherman, Garth D. Ehrlich, Benjamin Janto, Robert M. Williams, Christopher M. Rath
  • Biosynthetic pathway for heterologous expression of a nonribosomal peptide synthetase drug and analogs
    Patent number: 8815562
    Abstract: The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: August 26, 2014
    Assignees: The Regenys of the University of Michigan, Allegheny-Singer Research Institute, Colorado State University Research Foundation
    Inventors: David H. Sherman, Garth D. Ehrlich, Benjamin Janto, Robert M. Williams, Christopher M. Rath
  • Biosynthetic Pathway for Heterologous Expression of a Nonribosomal Peptide Synthetase Drug and Analogs
    Publication number: 20130095533
    Abstract: The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.
    Type: Application
    Filed: April 15, 2011
    Publication date: April 18, 2013
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, CLORADO STATE UNIVERSITY RESEARCH FOUNDATION, ALLEGHENY-SINGER RESEARCH INSTITUTE
    Inventors: David H. Sherman, Garth D. Ehrlich, Benjamin Janto, Robert M. Williams, Christopher M. Rath
  • Selected nucleotide sequences isolated from pathogenic strains of haemophilus influenzae
    Publication number: 20110144318
    Abstract: A DNA sequence of Haemophilus influenzae clone 151_04 shown in SEQ. ID. NO. 1. A DNA sequence of Haemophilus influenzae clone 125_L2 shown in SEQ. ID. NO. 2. A DNA sequence of Haemophilus influenzae clone 179_D14 shown in SEQ. ID. NO. 3. A DNA sequence of Haemophilus influenzae clone 167_A16 shown in SEQ. ID. NO. 4.
    Type: Application
    Filed: August 15, 2007
    Publication date: June 16, 2011
    Inventors: Garth D. Ehrlich, Patricia Antalis, John Gladitz, Geza Erdos, Fen Z. Hu
  • Selected nucleotide sequences isolated from pathogenic strains of
    Patent number: 7268225
    Abstract: A DNA sequence of Haemophilus influenzae clone 151_04 shown in SEQ. ID. NO. 1. A DNA sequence of Haemophilus influenzae clone 125_L2 shown in SEQ. ID. NO. 2. A DNA sequence of Haemophilus influenzae clone 179_D14 shown in SEQ. ID. NO. 3. A DNA sequence of Haemophilus influenzae clone 167_A16 shown in SEQ. ID. NO. 4.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: September 11, 2007
    Assignee: Allegheny-Singer Research Institute
    Inventors: Garth D. Ehrlich, Patricia Antalis, John Gladitz, Geza Erdos, Fen Z. Hu
  • Selected nucleotide sequences isolated from pathogenic strains of
    Patent number: 7115732
    Abstract: A DNA sequence of Haemophilus influenzae clone 151_04 shown in SEQ. ID. NO. 1. A DNA sequence of Haemophilus influenzae clone 125_L2 shown in SEQ. ID. NO. 2. A DNA sequence of Haemophilus influenzae clone 179_D14 shown in SEQ. ID. NO. 3. A DNA sequence of Haemophilus influenzae clone 167_A16 shown in SEQ. ID. NO. 4.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: October 3, 2006
    Assignee: Allegheny-Singer Research Institute
    Inventors: Garth D. Ehrlich, Patricia Antalis, John Gladitz, Geza Erdos, Fen Z. Hu
  • Selected nucleotide sequences isolated from pathogenic strains of Haemophilus influenzae
    Patent number: 6969762
    Abstract: A DNA sequence of Haemophilus influenzae clone 151_04 shown in SEQ. ID. NO. 1. A DNA sequence of Haemophilus influenzae clone 125_L2 shown in SEQ. ID. NO. 2. A DNA sequence of Haemophilus influenzae clone 179_D14 shown in SEQ. ID. NO. 3. A DNA sequence of Haemophilus influenzae clone 167_A16 shown in SEQ. ID. NO. 4.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: November 29, 2005
    Assignee: Allegheny-Singer Research Institute
    Inventors: Garth D. Ehrlich, Patricia Antalis, John Gladitz, Geza Erdos, Fen Z. Hu
  • Method for determining whether a human patient is susceptible to hereditary pancreatitis, and primers therefore
    Patent number: 6406846
    Abstract: A method for determining whether a human patient is susceptible to hereditary pancreatitis. The method comprises the steps of obtaining nucleic acid from the human patient. Then there is the step of checking the nucleic acid for a mutation that indicates hereditary pancreatitis. A primer which reacts with a human trypsinogen gene to identify hereditary pancreatitis. A method for detecting in a human a mutation in a trypsinogen gene indicative of hereditary pancreatitis. The invention comprises the steps of obtaining a sample having DNA of the patient. Then there is the step of processing the sample so the DNA will be recognized by a desired restriction enzyme. Next there is the step of introducing the desired restriction enzyme to the DNA wherein the recognizing of the desired restriction enzyme to the DNA indicates the presence of the mutation.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: June 18, 2002
    Inventors: David Whitcomb, Garth D. Ehrlich, Michael C. Gorry
  • PCR assay for bacterial and viral meningitis
    Patent number: 6258570
    Abstract: A multiplex assay is provided for the simultaneous detection and discrimination of pathogens that cause bacterial and viral meningitis.
    Type: Grant
    Filed: April 17, 1998
    Date of Patent: July 10, 2001
    Assignee: University of Pittsburgh
    Inventors: Joseph Z. Glustein, Garth D. Ehrlich, Yingze Zhang