Patents by Inventor Garth J. Simpson

Garth J. Simpson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • System and method of extending the linear dynamic range of event counting
    Patent number: 9767258
    Abstract: A method and apparatus for photon, ion or particle counting described that provides seven orders of magnitude of linear dynamic range (LDR) for a single detector. By explicitly considering the log-normal probability distribution in voltage transients as a function of the number of photons, ions or particles present, the binomial distribution of observed counts for a given threshold, the mean number of photons, ions or particles can be determined well beyond the conventional limit.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: September 19, 2017
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Garth J. Simpson, David Joseph Kissick, Ryan Muir
  • Multiphoton luminescence imaging of protein crystals
    Patent number: 8946655
    Abstract: A method for detecting protein crystals comprises: illuminating a sample with a laser to produce multiphoton excitation; collecting an emission spectrum; and determining whether the sample comprises protein crystals.
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: February 3, 2015
    Assignee: Purdue Research Foundation
    Inventors: Garth J. Simpson, Ellen J. Gualtieri, David J. Kissick, Jeremy Madden
  • Imaging crystalline domains of small molecules
    Patent number: 8836925
    Abstract: An apparatus and method for performing volume scanning of a sample comprised of chiral materials disposed in a matrix of non-chiral materials is disclosed. A laser is raster scanned in a plane of the volume such that the intensity of energy in the focal region is sufficient to generate second harmonic (SHG) energy. This energy is detected and may be processed into three dimensional images of the volume. The raster pattern is repeatedly stepped over an area of the sample so as to produce three dimensional images of time-dependent processes.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: September 16, 2014
    Assignee: Purdue Research Foundation
    Inventors: Garth J. Simpson, Duangporn Wanapun, Lynne S. Taylor, Umesh S. Kestur, Scott J. Toth
  • SYSTEM AND METHOD OF EXTENDING THE LINEAR DYNAMIC RANGE OF EVENT COUNTING
    Publication number: 20130275054
    Abstract: A method and apparatus for photon, ion or particle counting described that provides seven orders of magnitude of linear dynamic range (LDR) for a single detector. By explicitly considering the log-normal probability distribution in voltage transients as a function of the number of photons, ions or particles present, the binomial distribution of observed counts for a given threshold, the mean number of photons, ions or particles can be determined well beyond the conventional limit.
    Type: Application
    Filed: September 27, 2011
    Publication date: October 17, 2013
    Applicant: Purdue Research Foundation
    Inventors: Garth J. Simpson, David Joseph Klsslck, Ryan Muir
  • IMAGING CRYSTALLINE DOMAINS OF SMALL MOLECULES
    Publication number: 20130057848
    Abstract: An apparatus and method for performing volume scanning of a sample comprised of chiral materials disposed in a matrix of non-chiral materials is disclosed. A laser is raster scanned in a plane of the volume such that the intensity of energy in the focal region is sufficient to generate second harmonic (SHG) energy. This energy is detected and may be processed into three dimensional images of the volume. The raster pattern is repeatedly stepped over an area of the sample so as to produce three dimensional images of time-dependent processes.
    Type: Application
    Filed: May 4, 2012
    Publication date: March 7, 2013
    Inventors: Garth J. Simpson, Duangporn Wanapun, Lynne S. Taylor, Umesh S. Kestur, Scott J. Toth
  • MULTIPHOTON LUMINESCENCE IMAGING OF PROTEIN CRYSTALS
    Publication number: 20120241647
    Abstract: A method for detecting protein crystals comprises: illuminating a sample with a laser to produce multiphoton excitation; collecting an emission spectrum; and determining whether the sample comprises protein crystals.
    Type: Application
    Filed: September 27, 2010
    Publication date: September 27, 2012
    Applicant: Purdue Research Foundation
    Inventors: Garth J. Simpson, Ellen J. Gualtieri, David J. Kissick, Jeremy Madden
  • Non-linear optical imaging of protein crystals
    Patent number: 8030077
    Abstract: Methods for detecting and evaluating the quality of protein crystals are provided comprising subjecting a sample to second order non-linear optical imaging and detecting the second harmonic generation signal.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: October 4, 2011
    Assignee: Purdue Research Foundation
    Inventors: Garth J. Simpson, Ronald D. Wampler, David J. Kissick
  • Non-linear Optical Imaging of Protein Crystals
    Publication number: 20100031748
    Abstract: Methods for detecting and evaluating the quality of protein crystals are provided comprising subjecting a sample to second order non-linear optical imaging and detecting the second harmonic generation signal.
    Type: Application
    Filed: August 7, 2009
    Publication date: February 11, 2010
    Inventors: Garth J. Simpson, Ronald D. Wampler, David J. Kissick
  • System and method for nonlinear optical null ellipsometry
    Patent number: 7336359
    Abstract: Nonlinear optical null ellipsometry is disclosed as a method to evaluate second-order nonlinearities on and off resonance in thin surface films and bulk materials.
    Type: Grant
    Filed: May 3, 2005
    Date of Patent: February 26, 2008
    Assignee: Purdue Research Foundation
    Inventors: Garth J. Simpson, Ryan M. Plocinik, Mark Polizzi
  • Microfluidic device including a micropump
    Publication number: 20030170131
    Abstract: Microfluidic devices are disclosed. The microfluidic devices comprise pumps and mixers in which a microrotor rotated by coupled dipoles induced by alternating electric fields moves fluids in which it is immersed.
    Type: Application
    Filed: March 8, 2002
    Publication date: September 11, 2003
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Richard N. Zare, Garth J. Simpson, Clyde F. Wilson