Patents by Inventor Garth Jason Simpson

Garth Jason Simpson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200192074
    Abstract: A method for imaging a sample, wherein the sample changes a polarization state of light as a function of position, wherein the method includes changing a polarization state of a purely polarized light of an incident light striking a miro-retarder array, thereby inducing a changed polarization state of the polarization state. The micro-retarder array is placed in a rear conjugate focal plane of a microscope. The method additionally includes projecting the changed polarization state of the polarization state into an object plane of the microscope containing the sample.
    Type: Application
    Filed: December 13, 2019
    Publication date: June 18, 2020
    Applicant: Purdue Research Foundation
    Inventors: Garth Jason Simpson, James Ulcickas, Fengyuan Deng, Changqin Ding
  • Publication number: 20200174142
    Abstract: The present disclosure provides a system and method for efficiently mining multi-threshold measurements acquired using photon counting pixel-array detectors for spectral imaging and diffraction analyses. Images of X-ray intensity as a function of X-ray energy were recorded on a 6 megapixel X-ray photon counting array detector through linear fitting of the measured counts recorded as a function of counting threshold. An analytical model is disclosed for describing the probability density of detected voltage, utilizing fractional photon counting to account for edge/corner effects from voltage plumes that spread across multiple pixels. Three-parameter fits to the model were independently performed for each pixel in the array for X-ray scattering images acquired for 13.5 keV and 15.0 keV X-ray energies. From the established pixel responses, multi-threshold composite images produced from the sum of 13.5 keV and 15.
    Type: Application
    Filed: December 4, 2018
    Publication date: June 4, 2020
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Garth Jason Simpson, Ryan Douglas Muir, Nicholas Roman Pogranichniy
  • Publication number: 20200082282
    Abstract: A method for inducing a covert misclassification performed on a non-transitory computer readable medium, the method includes identifying a target position. The method further includes creating a spectral perturbation tensor. The spectral perturbation tensor is configured to shift a projection of an initial spectrum towards the target position. Additionally, the method includes combining the spectral perturbation tensor to the initial spectrum. Further, the method includes classifying the combination of the spectral perturbation tensor and the initial spectrum with an established classifier, thereby designing the spectral perturbation tensor such that the combination is misclassified.
    Type: Application
    Filed: September 10, 2019
    Publication date: March 12, 2020
    Applicant: Purdue Research Foundation
    Inventors: Garth Jason Simpson, James Ulcicks, Casey Smith, Alex Sherman
  • Publication number: 20200072745
    Abstract: A system including a first micro-retarder array, wherein the first micro-retarder array is configured to convert a purely polarized light of an incident light into two components. The system additionally includes an optical device, wherein the optical device is configured to collimate the two components to two foci planes. Moreover, the system includes a second micro-retarder array, wherein the second micro-retarder array is configured to combine a set of two components of the incident light, thereby producing a second purely polarized light. Further the system includes a detector, wherein the detector is configured to receive the second purely polarized light.
    Type: Application
    Filed: September 4, 2019
    Publication date: March 5, 2020
    Applicant: Purdue Research Foundation
    Inventors: Garth Jason Simpson, Fengyuan Deng, Changqin Ding, Chen Li
  • Patent number: 10416068
    Abstract: A quantitative optical microscopy arrangement is described. Specifically, a digital filter derived from linear discriminant analysis is described for recovering impulse responses in applications that may include photon counting from a high speed photodetector and applied to remove ringing distortions from impedance mismatch in multiphoton fluorescence microscopy. Training of the digital filter is achieved by defining temporally coincident and non-coincident transients and identifying the projection within filter-space that best separates the two classes. The training allows rapid data analysis by digital filtering. The LDA filter is also capable of recovering deconvolved impulses for single photon counting from highly distorted ringing waveforms from an impedance mismatched photomultiplier tube.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: September 17, 2019
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Garth Jason Simpson, Ryan Douglas Muir, Shane Zachary Sullivan
  • Patent number: 10409047
    Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: September 10, 2019
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Garth Jason Simpson, Charles Addison Bouman, Ryan Douglas Muir, Shane Sullivan, Justin Allen Newman, Mark Carlsen, Suhas Sreehari
  • Patent number: 10309902
    Abstract: A method for quantifying crystallinity within a sample using second harmonic generation microscopy is described herein. In one aspect, a method for reducing the timeframe for accelerated stability testing of amorphous solid dispersions of active pharmaceutical ingredients though identifying regions of interest to quantify crystallinity and composition is presented herein.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: June 4, 2019
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Garth Jason Simpson, Paul David Schmitt
  • Patent number: 10162942
    Abstract: A method and apparatus for photon, ion or particle counting described that provides seven orders of magnitude of linear dynamic range (LDR) for a single detector. By explicitly considering the log-normal probability distribution in voltage transients as a function of the number of photons, ions or particles present, the binomial distribution of observed counts for a given threshold, the mean number of photons, ions or particles can be determined well beyond the conventional limit.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: December 25, 2018
    Assignee: Purdue Research Foundation
    Inventors: Garth Jason Simpson, Ryan Douglas Muir, David Joseph Kissick
  • Patent number: 10145968
    Abstract: The present disclosure provides a system and method for efficiently mining multi-threshold measurements acquired using photon counting pixel-array detectors for spectral imaging and diffraction analyses. Images of X-ray intensity as a function of X-ray energy were recorded on a 6 megapixel X-ray photon counting array detector through linear fitting of the measured counts recorded as a function of counting threshold. An analytical model is disclosed for describing the probability density of detected voltage, utilizing fractional photon counting to account for edge/corner effects from voltage plumes that spread across multiple pixels. Three-parameter fits to the model were independently performed for each pixel in the array for X-ray scattering images acquired for 13.5 keV and 15.0 keV X-ray energies. From the established pixel responses, multi-threshold composite images produced from the sum of 13.5 keV and 15.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: December 4, 2018
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Garth Jason Simpson, Ryan Douglas Muir, Nicholas Roman Pogranichniy
  • Publication number: 20180313764
    Abstract: An impact-driven apparatus and method to achieve triboluminescence of homochiral API crystals as a measurement tool for rapidly assessing the presence of trace crystallinity within nominally amorphous pharmaceutical powders. The apparatus may include a kinetic energy director and two plates which hold a sample for testing. The triboluminescence may also be achieve by an acoustic transducer.
    Type: Application
    Filed: September 27, 2016
    Publication date: November 1, 2018
    Applicant: Purdue Research Foundation
    Inventors: Garth Jason Simpson, Paul David Schmitt, Scott Robert Griffin, Casey Jake Smith
  • Patent number: 10113965
    Abstract: Methods for determining the 3-D structures of proteins. Such a method includes incorporating a compound into a protein crystal such that the compound enhances the activity of the protein crystal to second harmonic generation, illuminating the protein crystal with a sufficiently intense light to cause second harmonic generation by the protein crystal, and detecting a second harmonic generation response produced by the protein crystal that is suitable for protein structure determination by diffraction analysis.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: October 30, 2018
    Assignee: Purdue Research Foundation
    Inventors: Garth Jason Simpson, Justin Allen Newman, Nicholas Roman Pogranichniy, Nicole Mulready Scarborough
  • Publication number: 20180068090
    Abstract: A method and apparatus for photon, ion or particle counting described that provides seven orders of magnitude of linear dynamic range (LDR) for a single detector. By explicitly considering the log-normal probability distribution in voltage transients as a function of the number of photons, ions or particles present, the binomial distribution of observed counts for a given threshold, the mean number of photons, ions or particles can be determined well beyond the conventional limit.
    Type: Application
    Filed: September 12, 2017
    Publication date: March 8, 2018
    Inventors: Garth Jason Simpson, Ryan Douglas Muir, David Joseph Kissick
  • Publication number: 20180052103
    Abstract: Methods for determining the 3-D structures of proteins. Such a method includes incorporating a compound into a protein crystal such that the compound enhances the activity of the protein crystal to second harmonic generation, illuminating the protein crystal with a sufficiently intense light to cause second harmonic generation by the protein crystal, and detecting a second harmonic generation response produced by the protein crystal that is suitable for protein structure determination by diffraction analysis.
    Type: Application
    Filed: March 4, 2016
    Publication date: February 22, 2018
    Inventors: Garth Jason Simpson, Justin Allen Newman, Nicholas Roman Pogranichniy, Nicole Mulready Scarborough
  • Publication number: 20180045939
    Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.
    Type: Application
    Filed: October 4, 2017
    Publication date: February 15, 2018
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Garth Jason Simpson, Charles Addison Bouman, Ryan Douglas Muir, Shane Sullivan, Justin Allen Newman, Mark Carlsen, Suhas Sreehari
  • Patent number: 9784960
    Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: October 10, 2017
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Garth Jason Simpson, Charles Addison Bouman, Ryan Douglas Muir, Shane Sullivan, Justin Allen Newman, Mark Carlsen, Suhas Sreehari
  • Publication number: 20170212053
    Abstract: A method for quantifying crystallinity within a sample using second harmonic generation microscopy is described herein. In one aspect, a method for reducing the timeframe for accelerated stability testing of amorphous solid dispersions of active pharmaceutical ingredients though identifying regions of interest to quantify crystallinity and composition is presented herein.
    Type: Application
    Filed: September 28, 2015
    Publication date: July 27, 2017
    Applicant: Purdue Research Foundation
    Inventors: Garth Jason Simpson, Paul David Schmitt
  • Publication number: 20160070093
    Abstract: A quantitative optical microscopy arrangement is described. Specifically, a digital filter derived from linear discriminant analysis is described for recovering impulse responses in applications that may include photon counting from a high speed photodetector and applied to remove ringing distortions from impedance mismatch in multiphoton fluorescence microscopy. Training of the digital filter is achieved by defining temporally coincident and non-coincident transients and identifying the projection within filter-space that best separates the two classes. The training allows rapid data analysis by digital filtering. The LDA filter is also capable of recovering deconvolved impulses for single photon counting from highly distorted ringing waveforms from an impedance mismatched photomultiplier tube.
    Type: Application
    Filed: September 11, 2014
    Publication date: March 10, 2016
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Garth Jason Simpson, Ryan Douglas Muir, Shane Zachary Sullivan
  • Publication number: 20160004060
    Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.
    Type: Application
    Filed: June 10, 2015
    Publication date: January 7, 2016
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Garth Jason Simpson, Charles Addison Bouman, Ryan Douglas Muir, Shane Sullivan, Justin Allen Newman, Mark Carlsen
  • Publication number: 20150323687
    Abstract: The present disclosure provides a system and method for efficiently mining multi-threshold measurements acquired using photon counting pixel-array detectors for spectral imaging and diffraction analyses. Images of X-ray intensity as a function of X-ray energy were recorded on a 6 megapixel X-ray photon counting array detector through linear fitting of the measured counts recorded as a function of counting threshold. An analytical model is disclosed for describing the probability density of detected voltage, utilizing fractional photon counting to account for edge/corner effects from voltage plumes that spread across multiple pixels. Three-parameter fits to the model were independently performed for each pixel in the array for X-ray scattering images acquired for 13.5 keV and 15.0 keV X-ray energies. From the established pixel responses, multi-threshold composite images produced from the sum of 13.5 keV and 15.
    Type: Application
    Filed: May 11, 2015
    Publication date: November 12, 2015
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Garth Jason Simpson, Ryan Douglas Muir, Nicholas Roman Pogranichniy