Patents by Inventor Garth Jason Simpson
Garth Jason Simpson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230400410Abstract: Methods for measuring diffusion in a medium. One method includes dissolving a fluorescent sample in a medium, imaging the fluorescent sample with a patterned illumination Fluorescence Recovery After Photobleaching (FRAP) technique, and analyzing a set of microscope images of the photobleached dissolved fluorescent sample with the patterned illumination using a Fourier Transform (FT) FRAP technique.Type: ApplicationFiled: August 28, 2023Publication date: December 14, 2023Inventors: Garth Jason Simpson, Andreas C. Geiger
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Patent number: 11740180Abstract: Methods for measuring diffusion in a medium. One method includes dissolving a fluorescent sample in a medium, imaging the fluorescent sample with a patterned illumination Fluorescence Recovery After Photobleaching (FRAP) technique, and analyzing a set of microscope images of the photobleached dissolved fluorescent sample with the patterned illumination using a Fourier Transform (FT) FRAP technique.Type: GrantFiled: September 28, 2021Date of Patent: August 29, 2023Assignee: PURDUE RESEARCH FOUNDATIONInventors: Garth Jason Simpson, Andreas C. Geiger
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Patent number: 11692877Abstract: A method for phase contrasting-correlation spectroscopy: converting an incident linearly polarized light into two polarized components (polarized divergent and convergent components, wherein the polarized divergent component is orthogonal to the polarized convergent component), focusing each of the polarized divergent component and the polarized convergent component into a focal plane, thereby producing two focus planes constituting a reference focus (RF) plane and a sample focus (SF) plane; placing a sample at the SF plane and ambient conditions of the sample at the RF plane, resulting in a phase shift between the two polarized components; reconstituting the two phase-shifted polarized components into a phase-shifted linearly polarized light; detecting the phase-shifted linearly polarized light; calculating phase and intensity of the sample from the phase-shifted linearly polarized light; establishing an autocorrelation of phase and intensity of the phase-shifted linearly polarized light; and generating corrType: GrantFiled: November 4, 2021Date of Patent: July 4, 2023Assignee: Purdue Research FoundationInventors: Garth Jason Simpson, Chen Li, Changqin Ding
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Patent number: 11656164Abstract: A method of obtaining a measurement signal representative of the particle size distributions in nanocrystal suspensions that includes a step of providing a first light beam along a first axis to a first micro-retarder array to generate polarization wavefront shaped light. The shaped light is applied to an objective configured to focus two orthogonally polarized components of the polarization wavefront shaped light to produce first and second axially offset foci along the first axis. A sample having particles in suspension is disposed in one foci to produce a measurement optical signal having phase and intensity values corresponding to at least some of the particles in suspension. The method also includes determining intensity and quantitative phase information as a function of time based on the optical signals.Type: GrantFiled: May 24, 2021Date of Patent: May 23, 2023Assignee: Purdue Research FoundationInventors: Garth Jason Simpson, Chen Li, Changqin Ding
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Patent number: 11635610Abstract: A method for imaging a sample, wherein the sample changes a polarization state of light as a function of position, wherein the method includes changing a polarization state of a purely polarized light of an incident light striking a micro-retarder array, thereby inducing a changed polarization state of the polarization state. The micro-retarder array is placed in a rear conjugate focal plane of a microscope. The method additionally includes projecting the changed polarization state of the polarization state into an object plane of the microscope containing the sample.Type: GrantFiled: May 18, 2021Date of Patent: April 25, 2023Assignee: Purdue Research FoundationInventors: Garth Jason Simpson, James Ulcickas, Fengyuan Deng, Changqin Ding
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Patent number: 11619581Abstract: A system including a first micro-retarder array, wherein the first micro-retarder array is configured to convert a purely polarized light of an incident light into two components. The system additionally includes an optical device, wherein the optical device is configured to collimate the two components to two foci planes. Moreover, the system includes a second micro-retarder array, wherein the second micro-retarder array is configured to combine a set of two components of the incident light, thereby producing a second purely polarized light. Further the system includes a detector, wherein the detector is configured to receive the second purely polarized light.Type: GrantFiled: April 26, 2021Date of Patent: April 4, 2023Assignee: Purdue Research FoundationInventors: Garth Jason Simpson, Fengyuan Deng, Changqin Ding, Chen Li
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Publication number: 20220099574Abstract: Methods for measuring diffusion in a medium. One method includes dissolving a fluorescent sample in a medium, imaging the fluorescent sample with a patterned illumination Fluorescence Recovery After Photobleaching (FRAP) technique, and analyzing a set of microscope images of the photobleached dissolved fluorescent sample with the patterned illumination using a Fourier Transform (FT) FRAP technique.Type: ApplicationFiled: September 28, 2021Publication date: March 31, 2022Applicant: PURDUE RESEARCH FOUNDATIONInventors: Garth Jason Simpson, Andreas C. Geiger
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Publication number: 20220057266Abstract: A method for phase contrasting-correlation spectroscopy: converting an incident linearly polarized light into two polarized components (polarized divergent and convergent components, wherein the polarized divergent component is orthogonal to the polarized convergent component), focusing each of the polarized divergent component and the polarized convergent component into a focal plane, thereby producing two focus planes constituting a reference focus (RF) plane and a sample focus (SF) plane; placing a sample at the SF plane and ambient conditions of the sample at the RF plane, resulting in a phase shift between the two polarized components; reconstituting the two phase-shifted polarized components into a phase-shifted linearly polarized light; detecting the phase-shifted linearly polarized light; calculating phase and intensity of the sample from the phase-shifted linearly polarized light; establishing an autocorrelation of phase and intensity of the phase-shifted linearly polarized light; and generating corrType: ApplicationFiled: November 4, 2021Publication date: February 24, 2022Applicant: Purdue Research FoundationInventors: Garth Jason Simpson, Chen Li, Changqin Li
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Publication number: 20220026331Abstract: A method of obtaining a measurement signal representative of the particle size distributions in nanocrystal suspensions that includes a step of providing a first light beam along a first axis to a first micro-retarder array to generate polarization wavefront shaped light. The shaped light is applied to an objective configured to focus two orthogonally polarized components of the polarization wavefront shaped light to produce first and second axially offset foci along the first axis. A sample having particles in suspension is disposed in one foci to produce a measurement optical signal having phase and intensity values corresponding to at least some of the particles in suspension. The method also includes determining intensity and quantitative phase information as a function of time based on the optical signals.Type: ApplicationFiled: May 24, 2021Publication date: January 27, 2022Inventors: Garth Jason Simpson, Chen Li, Changqin Li
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Publication number: 20210278656Abstract: A method for imaging a sample, wherein the sample changes a polarization state of light as a function of position, wherein the method includes changing a polarization state of a purely polarized light of an incident light striking a micro-retarder array, thereby inducing a changed polarization state of the polarization state. The micro-retarder array is placed in a rear conjugate focal plane of a microscope. The method additionally includes projecting the changed polarization state of the polarization state into an object plane of the microscope containing the sample.Type: ApplicationFiled: May 18, 2021Publication date: September 9, 2021Applicant: Purdue Research FoundationInventors: Garth Jason Simpson, James Ulcickas, Fengyuan Deng, Changqin Ding
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Publication number: 20210262930Abstract: A system including a first micro-retarder array, wherein the first micro-retarder array is configured to convert a purely polarized light of an incident light into two components. The system additionally includes an optical device, wherein the optical device is configured to collimate the two components to two foci planes. Moreover, the system includes a second micro-retarder array, wherein the second micro-retarder array is configured to combine a set of two components of the incident light, thereby producing a second purely polarized light. Further the system includes a detector, wherein the detector is configured to receive the second purely polarized light.Type: ApplicationFiled: April 26, 2021Publication date: August 26, 2021Applicant: Purdue Research FoundationInventors: Garth Jason Simpson, Fengyuan Deng, Changqin Ding, Chen Li
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Patent number: 11042019Abstract: A method for imaging a sample, wherein the sample changes a polarization state of light as a function of position, wherein the method includes changing a polarization state of a purely polarized light of an incident light striking a micro-retarder array, thereby inducing a changed polarization state of the polarization state. The micro-retarder array is placed in a rear conjugate focal plane of a microscope. The method additionally includes projecting the changed polarization state of the polarization state into an object plane of the microscope containing the sample.Type: GrantFiled: December 13, 2019Date of Patent: June 22, 2021Assignee: Purdue Research FoundationInventors: Garth Jason Simpson, James Ulcickas, Fengyuan Deng, Changqin Ding
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Patent number: 11009456Abstract: A system including a first micro-retarder array, wherein the first micro-retarder array is configured to convert a purely polarized light of an incident light into two components. The system additionally includes an optical device, wherein the optical device is configured to collimate the two components to two foci planes. Moreover, the system includes a second micro-retarder array, wherein the second micro-retarder array is configured to combine a set of two components of the incident light, thereby producing a second purely polarized light. Further the system includes a detector, wherein the detector is configured to receive the second purely polarized light.Type: GrantFiled: September 4, 2019Date of Patent: May 18, 2021Assignee: Purdue Research FoundationInventors: Garth Jason Simpson, Fengyuan Deng, Changqin Ding, Chen Li
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Publication number: 20200192074Abstract: A method for imaging a sample, wherein the sample changes a polarization state of light as a function of position, wherein the method includes changing a polarization state of a purely polarized light of an incident light striking a miro-retarder array, thereby inducing a changed polarization state of the polarization state. The micro-retarder array is placed in a rear conjugate focal plane of a microscope. The method additionally includes projecting the changed polarization state of the polarization state into an object plane of the microscope containing the sample.Type: ApplicationFiled: December 13, 2019Publication date: June 18, 2020Applicant: Purdue Research FoundationInventors: Garth Jason Simpson, James Ulcickas, Fengyuan Deng, Changqin Ding
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Publication number: 20200174142Abstract: The present disclosure provides a system and method for efficiently mining multi-threshold measurements acquired using photon counting pixel-array detectors for spectral imaging and diffraction analyses. Images of X-ray intensity as a function of X-ray energy were recorded on a 6 megapixel X-ray photon counting array detector through linear fitting of the measured counts recorded as a function of counting threshold. An analytical model is disclosed for describing the probability density of detected voltage, utilizing fractional photon counting to account for edge/corner effects from voltage plumes that spread across multiple pixels. Three-parameter fits to the model were independently performed for each pixel in the array for X-ray scattering images acquired for 13.5 keV and 15.0 keV X-ray energies. From the established pixel responses, multi-threshold composite images produced from the sum of 13.5 keV and 15.Type: ApplicationFiled: December 4, 2018Publication date: June 4, 2020Applicant: PURDUE RESEARCH FOUNDATIONInventors: Garth Jason Simpson, Ryan Douglas Muir, Nicholas Roman Pogranichniy
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Publication number: 20200082282Abstract: A method for inducing a covert misclassification performed on a non-transitory computer readable medium, the method includes identifying a target position. The method further includes creating a spectral perturbation tensor. The spectral perturbation tensor is configured to shift a projection of an initial spectrum towards the target position. Additionally, the method includes combining the spectral perturbation tensor to the initial spectrum. Further, the method includes classifying the combination of the spectral perturbation tensor and the initial spectrum with an established classifier, thereby designing the spectral perturbation tensor such that the combination is misclassified.Type: ApplicationFiled: September 10, 2019Publication date: March 12, 2020Applicant: Purdue Research FoundationInventors: Garth Jason Simpson, James Ulcicks, Casey Smith, Alex Sherman
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Publication number: 20200072745Abstract: A system including a first micro-retarder array, wherein the first micro-retarder array is configured to convert a purely polarized light of an incident light into two components. The system additionally includes an optical device, wherein the optical device is configured to collimate the two components to two foci planes. Moreover, the system includes a second micro-retarder array, wherein the second micro-retarder array is configured to combine a set of two components of the incident light, thereby producing a second purely polarized light. Further the system includes a detector, wherein the detector is configured to receive the second purely polarized light.Type: ApplicationFiled: September 4, 2019Publication date: March 5, 2020Applicant: Purdue Research FoundationInventors: Garth Jason Simpson, Fengyuan Deng, Changqin Ding, Chen Li
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Patent number: 10416068Abstract: A quantitative optical microscopy arrangement is described. Specifically, a digital filter derived from linear discriminant analysis is described for recovering impulse responses in applications that may include photon counting from a high speed photodetector and applied to remove ringing distortions from impedance mismatch in multiphoton fluorescence microscopy. Training of the digital filter is achieved by defining temporally coincident and non-coincident transients and identifying the projection within filter-space that best separates the two classes. The training allows rapid data analysis by digital filtering. The LDA filter is also capable of recovering deconvolved impulses for single photon counting from highly distorted ringing waveforms from an impedance mismatched photomultiplier tube.Type: GrantFiled: September 11, 2014Date of Patent: September 17, 2019Assignee: PURDUE RESEARCH FOUNDATIONInventors: Garth Jason Simpson, Ryan Douglas Muir, Shane Zachary Sullivan
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Patent number: 10409047Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.Type: GrantFiled: October 4, 2017Date of Patent: September 10, 2019Assignee: PURDUE RESEARCH FOUNDATIONInventors: Garth Jason Simpson, Charles Addison Bouman, Ryan Douglas Muir, Shane Sullivan, Justin Allen Newman, Mark Carlsen, Suhas Sreehari
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Patent number: 10309902Abstract: A method for quantifying crystallinity within a sample using second harmonic generation microscopy is described herein. In one aspect, a method for reducing the timeframe for accelerated stability testing of amorphous solid dispersions of active pharmaceutical ingredients though identifying regions of interest to quantify crystallinity and composition is presented herein.Type: GrantFiled: September 28, 2015Date of Patent: June 4, 2019Assignee: PURDUE RESEARCH FOUNDATIONInventors: Garth Jason Simpson, Paul David Schmitt