Patents by Inventor Garth Ringheim

Garth Ringheim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATING A BRUTON'S TYROSINE KINASE DISEASE OR DISORDER
    Publication number: 20170173011
    Abstract: The present invention provides methods of treating, stabilizing or lessening the severity or progression of a disease or disorder associated with Bruton's tyrosine kinase (BTK) TEC and interleukin-2-inducible T-cell kinase (ITK).
    Type: Application
    Filed: March 5, 2015
    Publication date: June 22, 2017
    Inventors: William Frederick Westlin, III, Garth Ringheim
  • Heterocyclic compounds as P2X7 ion channel blockers
    Patent number: 7741493
    Abstract: The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer's disease, etc.
    Type: Grant
    Filed: November 29, 2007
    Date of Patent: June 22, 2010
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Patrick Shum, Alexandre Gross, Liang Ma, Daniel G. McGarry, Gregory H. Merriman, David Rampe, Garth Ringheim, Jeffrey Stephen Sabol, Francis A. Volz
  • HETEROCYCLIC COMPOUNDS AS P2X7 ION CHANNEL BLOCKERS
    Publication number: 20080132550
    Abstract: The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer's disease, etc.
    Type: Application
    Filed: November 29, 2007
    Publication date: June 5, 2008
    Applicant: AVENTIS PHARMACEUTICALS INC.
    Inventors: Patrick SHUM, Alexandre GROSS, Liang MA, Daniel G. MCGARRY, Gregory H. MERRIMAN, David RAMPE, Garth RINGHEIM, Jeffrey Stephen SABOL, Francis A. VOLZ
  • Heterocyclic compounds as P2X7 ion channel blockers
    Patent number: 7326792
    Abstract: The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer's disease, etc.
    Type: Grant
    Filed: July 21, 2004
    Date of Patent: February 5, 2008
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Patrick Shum, Alexandre Gross, Liang Ma, Daniel G. McGarry, Gregory H. Merriman, David Rampe, Garth Ringheim, Jeffrey Stephen Sabol, Francis A. Volz
  • Heterocyclic compounds as P2X7 ion channel blockers
    Publication number: 20050026916
    Abstract: The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer's disease, etc.
    Type: Application
    Filed: July 21, 2004
    Publication date: February 3, 2005
    Applicant: Aventis Pharmaceuticals Inc.
    Inventors: Patrick Shum, Alexandre Gross, Liang Ma, Daniel McGarry, Gregory Merriman, David Rampe, Garth Ringheim, Jeffrey Sabol, Francis Volz