Abstract: Disclosed are quinoline and quinazoline compounds which modulate the activity of the gated ion channels. Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pain, inflammation, the neurological system, the gastrointestinal system and genitourinary system. Preferred compounds include quinoline or quinazoline derivatives substituted at the 4-position via N(H), C(O) or O moieties.

Abstract: A method of producing data representing a modified object based on data representing a reference object is disclosed. The method includes generating one or more offset surfaces based on the data representing the object, where one or more offset surfaces are offset from surfaces of the reference object, and where at least one of: the one or more offset surfaces defines an open surface, and the one or more offset surfaces defines a region having a surface to surface distance which is than a minimum thickness, generating an offset object including at least one of adding and removing one or more portions of at least one of the offset surfaces, where, at least partly because of the adding or removing of the one or more portions, the offset object both does not define an open surface and does not have a region thinner than the minimum thickness limit.

Abstract: A method of producing surface data from electronic polygonal data is disclosed. The method includes accessing the polygonal data with a computer, the polygonal data defining a mesh of polygonal data points and including a plurality of vertices, and where the polygonal data describes an object. The method also includes generating a plurality of bounded areas, each including one or more vertices of the polygonal data, expanding a plurality of the bounded areas by adding a plurality of vertices thereto, generating a surface for each of the expanded bounded areas based on the vertices of the expanded bounded areas, generating the surface data based at least in part on the surfaces, and storing the surface data in a computer readable data storage.

Abstract: The present disclosure provides methods of transitioning a patient being treated for pulmonary arterial hypertension with a non-selexipag prostacyclin pathway agent (PPA) to selexipag.

Abstract: A method of producing surface data from electronic polygonal data is disclosed. The method includes accessing the polygonal data with a computer, the polygonal data defining a mesh of polygonal data points and including a plurality of vertices, and where the polygonal data describes an object. The method also includes generating a plurality of bounded areas, each including one or more vertices of the polygonal data, expanding a plurality of the bounded areas by adding a plurality of vertices thereto, generating a surface for each of the expanded bounded areas based on the vertices of the expanded bounded areas, generating the surface data based at least in part on the surfaces, and storing the surface data in a computer readable data storage.

Abstract: Embodiments of a method and system for engaging a patient include receiving a set of user inputs from the patient at an interaction engine associated with a companion robot; at the interaction engine, determining a patient model for the patient; at the interaction engine, determining patient goals for the patient; at the interaction engine, generating an interaction plan including a conversation component and an animation component, based on the patient model and the patient goals; and executing the interaction plan with the companion robot, thereby promoting engagement between the patient and the companion robot, in improving healthcare of the patient.

Abstract: The invention disclosed herein generally relates to a device and methods to authenticate the composition of materials, including, but not limited to gold and silver coins and gold and silver bars. The invention stimulates the natural frequencies of the tested object and then compares them to a reference dataset to confirm its authenticity. It achieves this through use of a transducer that both vibrates the object and collects amplitude response, allowing for consistent and highly accurate analysis across a broad spectrum, including ultrasonic frequencies.

Abstract: Systems and methods of updating graphical objects are disclosed. The methods and systems receive polygonal data which describe discrete points on an object. A control mesh and a smoothed version of the control mesh are simultaneously displayed. When the control mesh is edited, the smoothed version is automatically updated by smoothing only a portion of the edited control mesh to generate a smoothed section, and replacing a portion of the smoothed version with at least a selected portion of the smoothed section.

Abstract: Embodiments of a method and system for engaging a patient include receiving a set of user inputs from the patient at an interaction engine associated with a companion robot; at the interaction engine, determining a patient model for the patient; at the interaction engine, determining patient goals for the patient; at the interaction engine, generating an interaction plan including a conversation component and an animation component, based on the patient model and the patient goals; and executing the interaction plan with the companion robot, thereby promoting engagement between the patient and the companion robot, in improving healthcare of the patient.

Abstract: A method of generating a design for a device is disclosed. The method includes electronically accessing a reference geometry representing the topology, and electronically accessing a source polygonal data model, where the source polygonal data model includes a plurality of source vertices. The method also includes modifying position characteristics of one or more of the source vertices, where the source vertices are modified so that after the source polygonal data model is subdivided, vertices in the subdivided polygonal data model corresponding with the modified source vertices conform to the reference geometry. The method also includes subdividing the source polygonal data model having the modified source vertices to generate the design, where subdividing the source polygonal data model causes vertices in the design to be positioned such that the design conforms with the reference geometry at least partly because of the modified position characteristics of the modified source vertices.

Abstract: Methods and systems of editing an electronic geometric model are disclosed. The method includes receiving a first indication which indicates that a portion of the polygonal data is to be modified, and moving a first vertex of the plurality of vertices from a first subdivision position defined by a subdivision algorithm to a second position. The movement of the first vertex from the first subdivision position to the second position results in a modification of the polygonal data. The method also includes generating a first vector identifying the movement of the first vertex from the first subdivision position to the second position, which first vector is defined by an initial point at the first subdivision position of the first vertex and a terminal point at the second position of the of the first vertex, and associating the first vector with the subdivision position of the first vertex.

Abstract: A method and system for creating and refilling holes in image data is disclosed herein. The method can include receiving scanned image data that represents a tangible object, and that can be generated by an object scanner from the tangible object and converting the scanned image data to polygonal data that can be a collection of vertices, edges and faces. The method can include identifying geometry in the polygonal data for hole cutting and cutting a hole by removing the identified geometry from the scanned image data. The method can include generating modified polygonal data by filling the cut hole with polygonal data and outputting the modified polygonal data.

Abstract: A method and system for graphic manipulation is provided. The graphic manipulation can be performed using a graphic manipulator that can have three mutually perpendicular axes indicators and a plurality of action icons associated with one or more of the axes. The graphic manipulator can be oriented with respect to axes of the object being manipulated. Based on the specific orientation of the graphic manipulator, and based on the selection of portions of the manipulated object some of the axis indicators and the plurality of action icons can be displayed and/or not displayed.

Abstract: Methods and systems for generating surface data from polygonal data are disclosed. The methods and systems receive polygonal data which describe discrete points on an object. The methods and systems analyze and use the data to calculate and define a continuous BREP object which accurately represents the original polygonal object. In some embodiments, the BREP object is modified and certain details of the modification operations are recorded. The polygonal data may be edited and a new BREP object created based on the edited polygonal data. The new BREP object may be automatically modified by automatically reperforming the recorded modification operations.

Abstract: Systems and methods of updating graphical objects are disclosed. The methods and systems receive polygonal data which describe discrete points on an object. A user gives an indication, and retopologized data for a region is automatically generated based on the indication such that the retopologized data has fewer geometries than the received polygonal data in the region.

Abstract: Methods and systems of editing an electronic geometric model are disclosed. The method includes receiving a first indication which indicates that a portion of the polygonal data is to be modified, and moving a first vertex of the plurality of vertices from a first subdivision position defined by a subdivision algorithm to a second position. The movement of the first vertex from the first subdivision position to the second position results in a modification of the polygonal data. The method also includes generating a first vector identifying the movement of the first vertex from the first subdivision position to the second position, which first vector is defined by an initial point at the first subdivision position of the first vertex and a terminal point at the second position of the of the first vertex, and associating the first vector with the subdivision position of the first vertex.

Abstract: A method of generating a design for a device is disclosed. The method includes electronically accessing a scan mesh representing a topology, and electronically accessing a source polygonal data model, where the source polygonal data model includes a plurality of source vertices. The method also includes modifying position characteristics of one or more of the source vertices, where the source vertices are modified so that after the source polygonal data model is subdivided, vertices in the subdivided source polygonal data model corresponding with the modified source vertices conform to the scan mesh. The method also includes subdividing the source polygonal data model having the modified source vertices to generate the design, where subdividing the source polygonal data model causes vertices in the design to be positioned such that the design conforms with the scan mesh at least partly because of the modified position characteristics of the modified source vertices.

Abstract: Methods and computer systems for generating and polygonal data are disclosed. The methods and systems receive polygonal data which describe discrete points on an object. The methods and systems algorithmically add vertices and edges prior to algorithmically smoothing and conforming the polygonal data in order to produce desired features, such as fillets, in the smoothed data.

Abstract: The invention disclosed herein generally relates to a device and methods to authenticate the composition of materials, including, but not limited to gold and silver coins and gold and silver bars. The invention stimulates the natural frequencies of the tested object and then compares them to a reference dataset to confirm its authenticity. It achieves this through use of a transducer that both vibrates the object and collects amplitude response, allowing for consistent and highly accurate analysis across a broad spectrum, including ultrasonic frequencies.

Abstract: Methods and systems for generating surface data from polygonal data are disclosed. The methods and systems receive polygonal data which describe discrete points on an object. The methods and systems analyze and use the data to calculate and define a continuous BREP object which accurately represents the original polygonal object. In some embodiments, the BREP object is modified and certain details of the modification operations are recorded. The polygonal data may be edited and a new BREP object created based on the edited polygonal data. The new BREP object may be automatically modified by automatically reperforming the recorded modification operations.