Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

Abstract: A process for removing hydrocarbon combustibles from the surface of metal particles and recovering the heat content therefrom is disclosed. The process is carried out in a system having a smoke collection zone, a heating zone and burner means supplied with fuel and air. The process includes charging the metal particles into a moving molten metal bath contained in the smoke collection zone. The charging generates smoke and vaporizes the hydrocarbon combustibles to provide unburned hydrocarbon fumes. A burner means is fired to draw transporting gas into the smoke collection zone to entrain and transport the smoke and fumes from the smoke collection zone to a jet stream exiting the burner means. The smoke and fumes are incinerated in the jet stream to provide hot gas. The transporting gas also contains oxygen for incinerating the smoke and fumes. The hot gas provided by incinerating the smoke and fumes is then jetted via the jet stream into the heating zone where its heat content is recovered.